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Katie Markan, PhD

Address: 3310C PBDB
Phone: (319) 335-7660
Email: kathleen-markan@uiowa.edu

Mentor: Matthew J. Potthoff, PhD

PhD Institution: University of Chicago, 2010

Research Description

  1. The role of adipose tissue in mediating the effects of Fibroblast Growth Factor-21 (FGF21).
  2. Regulation of beige adipocyte development and metabolism.
  3. Adipose tissue biology and metabolism.

Award(s)

  • NIH / NRSA Postdoctoral Fellowship, 2014
  • NIH / NIDDK K01 Mentored Research Scientist Development Award, 2016

Publication(s) 

  1. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W.Obesity-associated NLRC4 inflammasome activation drives breast cancer progression.  Nat Commun, 7:13007, 2016.  PMCID: PMC5059727
  2. ​Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 16(6):1548-1560, 2016. PMCID: PMC4981564
  3. ​Markan KR, Potthoff MJ. Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. Semin Cell Dev Biol 53:85-93, 2016. PMID: 26428296
  4. McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL, Kotas ME, Potthoff MJ, Richerson GB, Gillum MP. Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis. Cell Metab 21(5):692-705, 2015.  PMCID: PMC4565052​
  5. Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ. Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding. Diabetes, 63(12):4057-4063, 2014.  PMCID: PMC4238010