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Sean Deoni, PhD., Brown University, College of Engineering
ABSTRACT: Infancy and early childhood coincide with one of the most dynamic periods of brain development, plasticity, and learning. A key developmental process throughout this period is myelination, the establishment of the myelinated white matter, which facilitates rapid communication across the brain's eloquent networks and systems. Abnormalities in white matter development, leading to altered brain connectivity, are hypothesised to play an important role in many developmental, behavioral and neuropsychiatric disorders, such as autism, ADHD, and others. Unfortunately, little is known about the patterns of brain growth and white matter myelination throughout early childhood; how these patterns relate to functional maturation; or how they may be involved in various disorders. In this talk, we will describe an MR imaging method for specifically investigating myelination, and detail results from an ongoing longitudinal study of early brain development in healthy, typically developing infants and toddlers. Specifically, we will demonstrate the normative patterns of white matter myelination, detail associations between myelination and functional connectivity (derived using resting-state fMRI), as well as correlations between myelination and behavioral and cognitive maturation.
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Michael Zeineh, MD., PhD., Stanford University Medical Center
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Keynote Speaker: Kamil Ugurbil, Ph.D. - University of Minnesota, Center for Magnetic Resonance Research Symposium Information
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