Iowa Institute of Human Genetics

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  • N


    Next-generation sequencing

    Nonsense variant:

    A single base pair alteration which result in a premature stop codon.

    Nonsynonymous variant:

    A single base pair alteration which results in an altered amino acid.

    Novel variant:

    A DNA alteration which has not been previously reported in a public database.


    See nonsynonymous variant


    The building blocks of RNA and DNA polymers which consist of a nitrogenous base (adenine (A), guanine (G), thymine (T), or cytosine (C) in DNA; adenine (A), guanine (G), uracil (U), or cytosine (C) in RNA), a phosphate molecule, and a sugar molecule (deoxyribose in DNA; ribose in RNA)

    Null allele:

    An allele which results in a lack of the gene’s normal function.