Iowa Institute of Human Genetics

  • View Glossary Terms

  • L

    Locus (pl. loci):

    A specific position of a gene or DNA marker on a chromosome.

    Locus heterogeneity:

    Genes at different chromosomal positions (loci) result in the same phenotype.


    See loss-of-function mutation

    Loss-of-function mutation:

    A DNA alteration which results in reduced or abolished protein activity.


    Lundbeck Foundtation Centre for Applied Medical Genomics in Personalized Medicine