Stead Family Department of Pediatrics

Christopher S. Cooper, MD


Professor of Urology
Professor of Pediatrics

Contact Information

Primary Office: 1216 MERF
Iowa City, IA 52242
Phone: 319-335-8435

Office: 3251 RCP
Iowa City, IA 52242
Phone: 319-356-0743

Web: UI Health Care Profile


BA, University of Iowa
MD, University of Iowa College of Medicine

Residency, University of Iowa Hospitals and Clinics, Urology
Fellowship, Children's Hospital of Philadelphia, Pediatric Urology

Licensure and Certifications

Pediatric Urology Subspecialty Certification, American Board of Urology

Research Summary

Dr. Cooper's research focuses on the etiology, diagnosis and treatment of fetal genitourinary anomalies and pediatric voiding dysfunction. Recently, Dr. Cooper's research studies have concentrated on the treatment decision-making process in children with vesicoureteral reflux (VUR). VUR is the retrograde flow of urine from the bladder into the ureter, due to incompetence of the vesicoureteral valve (between the bladder and the ureter), which can lead to bacterial infection in the kidney. Because severe VUR (high grade), if left untreated, can lead to kidney damage, and mild (low grade) VUR may spontaneously resolve, parents and clinicians face a dilemma in determining which treatment, if any, is best for each child. Treatment may range from antibiotic prophylaxis to surgical intervention. Because surgery carries an inherent risk in any child, and long-term antibiotic use is debatable, careful consideration of all variables in each case of VUR must be considered. To further the understanding of VUR and which children are likely to benefit from various forms of intervention, Dr. Cooper and colleagues are actively investigating factors which may determine whether spontaneous resolution without sequelae is likely, or if intervention is warranted. Age, gender, grade of reflux, laterality, renal scarring, cause of reflux, as well as more complex factors such as bladder volume and pressure at onset of reflux, and bladder and bowel function, are all taken into account. Dr. Cooper and coworkers have analyzed these aspects and reported numerous findings, including the creation of a computational model to predict VUR outcome. Other aspects of Dr. Cooper's ongoing clinical research include prenatal hydronephrosis, including participation in an international database, overactive bladder, and reconstructive genitourinary surgery.

Selected Publications

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Arlen A, Pakalniskis B, Cooper C.  Asymptomatic chronic partial obstruction of a normal ureter following dextranomer/hyaluronic acid copolymer (Deflux®) injection for grade I vesicoureteral reflux..  J Pediatr Urol.  2012. 8:e27-30.

Arlen A, Boyt M, Cooper C.  School nurse perceptions and knowledge of pediatric toileting.  J Pediatr Urol.  2012. 8:205-8.

Braasch M, Griffith T, Cooper C, Austin J.  Description of a novel murine model for ileocystoplasty and early histologic changes.  ScientificWorldJournal.  2011. 11:1325-31.

Arlen A, Cooper C, Morcuende J, Austin J.  Safety and efficacy of spica casts for immobilization following initial bladder closure in classic bladder exstrophy.  J Pediatr Urol.  2011. 7:456-9.

Nepple K, Arlen A, Austin J, Cooper C.  The prognostic impact of an abnormal initial renal ultrasound on early reflux resolution.  J Pediatr Urol.  2011. 7:462-6.

Austin J, Cooper C.  Vesicoureteral reflux: who benefits from correction?.  Urol Clin North Am.  2010. 37:243-52.

Cooper C, Birusingh K, Austin J, Knudson M, Brophy P.  Distal ureteral diameter measurement objectively predicts vesicoureteral reflux outcome.  J Pediatr Urol.. 

Gerard L, Cooper C, Kleiber C.  Minimizing the Trauma of Pediatric Urethral Catheterization Using Lidocaine Gel. 

Knudson M, Austin J, Wald M, Makhlouf A, Niederberger C, Cooper C.  Neural Network for Predicting the Chance of 2-year Resolution in Children with Vesicoureteral Reflux. 

Date Last Modified: 06/06/2016 - 13:17:48