Ophthalmology And Visual Sciences

Michael G. Anderson, PhD


Associate Professor of Molecular Physiology and Biophysics
Associate Professor of Ophthalmology and Visual Sciences

Contact Information

Office: 3111A MERF
375 Newton Road
Iowa City, IA 52242
Phone: 319-335-7839

Lab: 3111 MERF
Iowa City, IA 52242
Phone: 319-335-7838

Email: michael-g-anderson@uiowa.edu


BA, Biology, Luther College
PhD, Physiology and Biophysics, University of Iowa

Fellowship, The Jackson Laboratory

Education/Training Program Affiliations

Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Research in my laboratory is aimed at understanding fundamental physiological properties of the eye and the pathophysiological mechanisms underlying a variety of complex eye diseases. Of primary interest are the glaucomas, a leading cause of blindness that affects approximately 70 million people worldwide. Glaucoma typically involves three types of events: molecular insults compromising the anterior chamber, increased intraocular pressure, and neurodegenerative retinal ganglion cell loss. Not surprisingly, the biological relationships linking these events are complex. Our approach for studying these events is founded in functional mouse genetics and supplemented by a variety of molecular, cellular, immunological, and neurobiological techniques. The premise for this approach is that stringently performed genetic studies offer great potential for overcoming the natural biological complexity of glaucoma. Current projects in the lab emphasize glaucoma phenotypes occuring in the front of the eye, including the molecular genetics of pigmentary glaucoma, exfoliative glaucoma, and central corneal thickness. We are also interested in new mouse models of glaucoma and have been studying an early onset form of glaucoma in nee mice that is associated with abnormalities of the aqueous drainage structures. In the long term, these studies will contribute to an increased understanding of eye diseases such as glaucoma, and ultimately to improved human therapies.

Center, Program and Institute Affiliations

Stephen A. Wynn Institute for Vision Research

Selected Publications

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Koehn D, Meyer K, Syed N, Anderson M.  Ketamine/Xylazine-Induced Corneal Damage in Mice.  PLOS ONE.  2015 July. 10(7):e0132804.

Gornjak T, Haraszti T, Garamus V, Buck A, Senkbeil T, Priebe M, Hedberg-Buenz A, Koehn D, Salditt T, Grunze M, Anderson M, Rosenhahn A.  Nano-scale morphology of melanosomes revealed by small-angle x-ray scattering.  PLoS One.  2014. 9(3):e90884.

Gorniak T, Haraszti T, Suhonen H, Yang Y, Hedberg-Buenz A, Koehn D, Heine R, Grunze M, Rosenhahn A, Anderson M.  Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis.  Pigment Cell and Melanoma Research.  2014. 27(5):831-824.

Fingert J, Burden J, Wang K, Kwon Y, Alward W, Anderson M.  Circumferential iris transillumination defects in exfoliation syndrome.  J Glaucoma.  2013. 22(7):555-558.

Lu Y, Vitart V, Burdon K, Khor C, Bykhovskaya Y, Mirshahi A, Hewitt A, Koehn D, Hysi P, Ramdas W, Zeller T, Vithana E, Cornes B, Tay W, Tai E, Cheng C, Liu J, Foo J, Saw S, Thorleifsson G, Stefansson K, Dimasi D, Mills R, Mountain J, Ang W, Hoehn R, Verhoeven V, Grus F, Wolfs R, Castagne R, Lackner K, Springelkamp H, Yang J, Jonasson F, Leung D, Chen L, Tham C, Rudan I, Vatayuk Z, Hayward C, Gibson J, Cree A, Macleod A, Ennis S, Polasek O, Campbell H, Wilson J, Viswanathan A, Fleck B, Li X, Siscovick D, Taylor K, Rotter J, Yazar S, Ulmer M, Li J, Yaspan B, Ozel A, Richards J, Moroi S, Haines J, Kang J, Pasquale L, Allingham R, Ashley-Koch A, Consortium N, Mitchell P, Wang J, Wright A, Pennell C, Spector T, Young T, Klayer C, Martin N, Montgomery G, Anderson M, Aung T, Willoughby C, Wiggs J, Pang C, Thorsteinsdottir U, Lotery A, Hammond C, van Duijn C, Hauser M, Rabinowitz Y, Pfeiffer N, Mackey D, Craig J, Macgregor S, Wong T.  Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.  Nat Genet.  2013. 45(2):155-163.

Anderson M.  NCBI MyBibliography. 

Anderson M.  Thomson Reuters ResearcherID on Web of Science: B-4580-2009. 

Date Last Modified: 06/06/2016 - 13:17:48