Andrew A. Pieper, MD, PhD


Professor of Psychiatry
Professor of Neurology, Radiation Oncology, Molecular Physiology and Biophysics

Contact Information

Office: 1318 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242
Phone: 319-353-5781

Web: Andrew A. Pieper Laboratory, Molecular Psychiatry Division
Web: Human Toxicology Program


BA, Biology, Chemistry, Earlham College, Richmond, IN
MD, Johns Hopkins University School of Medicine, Baltimore, MD
PhD, Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD

Internship, Internal Medicine, Johns Hopkins University School of Medicine
Residency, Psychiatry, Johns Hopkins University School of Medicine
Residency, Psychiatry Research, University of Texas Southwestern Medical Center
Fellowship, Psychiatry and Biochemistry, University of Texas Southwestern Medical Center

Licensure and Certifications

Psychiatry Certification, American Board of Psychiatry and Neurology

Selected Publications

Show All

Naidoo J, Jesus-Cortes H, Huntington P, Estill S, Starwalt R, Morlock L, Mangano T, Williams N, Pieper A, Ready J.  Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.  J Med Chem.  2014. 57(9):3746-54.

Dutca L, Stasheff S, Hedberg-Buenz A, Rudd D, Batra N, Blodi F, Yorek M, Yin T, Shankar M, Herlein J, Naidoo J, Morlock L, Williams N, Kardon R,  G, Pieper A, Harper M.  Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.  Invest Ophthalmol Vis Sci.  2014. 55(12):8330-41.

Yin T, Britt J, Jesus-Cortes H, Lu Y, Genova R, Khan M, Voorhees J, Shao J, Katzman A, Wassink C, McDaniel L, Newell E, Dutca L, Naidoo J, Cui H, Bassuk A, Harper M, McKnight S, Ready J, Pieper A.  P7C3 Neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury.  Cell Rep.  2014. 8(6):1731-40.

Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper A, Ready J, McKnight S.  P7C3 Neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.  Cell.  2014. 158(6):1324-34.

Xu P, Grueter B, Britt J, McDaniel L, Huntington P, Hodge R, Tran S, Mason B, Lee C, Vong L, Lowell B, Malenka R, Lutter M, Pieper A.  Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice..  Proc Natl Acad Sci U S A.  2013 June. 110(26):10759-64.

Caldera-Alvarado G, Khan D, Defina L, Pieper A, Brown E.  Relationship between asthma and cognition: the Cooper Center Longitudinal Study..  Allergy.  2013 April. 68(4):545-8.

Buchovecky C, Brown H, McDonald J, Lui B, Kyle S, Pieper A, Huang W, Katz D, Turley S, Russell D, Shendure J, Justice M.  A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.  Nat Genet.  2013. 45(9):1013-20.

Lee A, Ra S, Rajadhyaksha A, Britt J, De Jesus-Cortes H, Gonzales K, Lee A, Moosmang S, Hofmann F, Pieper A, Rajadhyaksha A.  Forebrain elimination of cacna1c mediates anxiety-like behavior in mice..  Mol Psychiatry.  2012 November. 17(11):1054-5.

Lee A, Gonzales K, Lee A, Moosmang S, Hofmann F, Pieper A, Rajadhyaksha A.  Selective genetic deletion of cacna1c in the mouse prefrontal cortex..  Mol psychiatry.  2012 November. 17(11):1051.

Tesla R, Wolf H, Xu P, Drawbridge J, Estill S, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams N, Ready J, McKnight S, Pieper A.  Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis..  Proc Natl Acad Sci U S A.  2012 October. 109(42):17016-21.

Date Last Modified: 06/06/2016 - 13:17:48