James Howe, MD


Director, Division of Surgical Oncology and Endocrine Surgery
Co-Director, Neuroendocrine Cancer Clinic
Professor of Surgery  - Surgical Oncology and Endocrine Surgery

Contact Information

Primary Office: 4644 JCP
Iowa City, IA 52242
Phone: 319-356-1727



MD, University of Vermont College of Medicine

Fellowship, Surgical Research Fellow, Washington University
Residency, General Surgery, Barnes Hospital
Fellowship, Clinical, Surgical Oncology, Memorial Sloan-Kettering Center

Licensure and Certifications

Certified, Advanced Trauma Life Support
Iowa Medical License, Iowa Board of Medicine
Board Certified, General Surgery, American Board of Surgery
Qualifying Examination, American Board of Surgery
Recertification Examination, American Board of Surgery

Research Summary

I am a Surgical Oncologist and Endocrine Surgeon who specializes in taking care of patients with cancers of the pancreas, liver, GI tract, soft tissue sarcoma, melanoma, thyroid, parathyroid, and adrenal glands; I am co-director of the neuroendocrine cancer clinic, Division Director of Surgical Oncology and Endocrine Surgery, and Professor of Surgery at the University of Iowa. My area of research expertise is in Familial Cancer Syndromes, genetic linkage, gene discovery, and gene expression studies. My postdoctoral training at Washington University under Helen Donis-Keller, Ph.D. and Samuel Wells, M.D., was directed at the identification of the gene for Multiple Endocrine Neoplasia Type 2. As a faculty member, my focus has been the genetics of Juvenile Polyposis, which led to the discovery of the 2 predisposing genes. More recently, I have developed a large clinical practice and research interest in the genetics of neuroendocrine tumors (NETs). Our current research focus is the study of gene expression profiles in pancreatic and small bowel NETs to identify new targets for imaging and treatment, and collection of families to search for predisposing genes.

All Publications

Maxwell J, Sherman S, Stashek K, O'Dorisio T, Bellizzi A, Howe J.  A Practical Method to Determine the Site of Unknown Primary in Metastatic Neuroendocrine Tumors.  Surgery.  2014. 

Sherman S, Maxwell J, O'Dorisio M, O'Dorisio T, Howe J.  Preoperative Pancreastatin Predicts Survival in Neuroendocrine Tumors.  Annals of Surgical Oncology.  2014. 21:2971-2980.

Carr J, Spanheimer P, Rajput M, Dahdaleh F, Lal G, Weigel R, Sugg S, Liao J, Howe J.  Discriminating Pheochromocytomas from Other Adrenal Lesions: The Dilemma of Elevated Catecholamines.  Annals of Surgical Oncology .  2013. 20:3855-3861.

Sherman S, Carr J, Wang D, O'Dorisio M, O'Dorisio T, Howe J.  Gastric inhibitory polypeptide receptor is a promising target for therapy in neuroendocrine tumors.  Surgery.  2013. 154:1206-1214.

Dahdaleh F, Calva D, O'Dorisio T, Carr J, Liao J, Mezhir J, Howe J.  Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution.  Annals of Surgical Oncology .  2012. 19:966-972.

Calva D, Dahdeleh F, Chinnathambi S, Nagy P, Larsen Haidle J, Weigel R, Howe J, Woodfield G.  Discovery of the BMPR1A Promoter and Germline Mutations that cause Juvenile Polyposis.  Human Molecular Genetics .  2010. 19:4654-4662.

Howe J, Bair J, Sayed M, Anderson M, Mitros F, Petersen G, Velculescu V, Traverso G, Vogelstein B.  Germline mutations of the gene for bone morphogenetic protein receptor 1A in juvenile polyposis .  Nature Genetics.  2001. 28:184-187.

Howe J, Karnell L, Menck H, Scott-Conner C.  Adenocarcinoma of the small bowel: Prognostic factors from the National Cancer Data Base.  Cancer.  1999. 86:2693-2706.

Howe J, Ringold J, Summers R, Mitros F, Nishimura D, Stone E.  A gene for familial juvenile polyposis maps to chromosome 18q21.1 .  American Journal of Human Genetics.  1998. 62:1129-1136.

Howe J, Roth S, Ringold J, Summers R, Jarvinen H, Sistonen P, Mitros F, Tomlinson I, Houlston R, Bevan S, Stone E, Aaltonen L.  Mutations in the SMAD4/DPC4 gene in juvenile polyposis .  Science.  1998. 280:1086-1088.

Date Last Modified: 06/06/2016 - 13:17:48