Radiation Oncology

Prabhat Goswami, PhD


Professor of Radiation Oncology

Contact Information

Email: prabhat-goswami@uiowa.edu
Web: Departmental Profile
Web: Human Toxicology
Web: Molecular and Cellular Biology
Web: Biosciences


BS, Chemistry, St. Anthony's College, Shillong, India
MS, Chmistry, Gauhati University, India
PhD, Chemistry, Gauhati University, India

Post Doctorate, Department of Microbiology, University of Miami
Fellowship, Regional Research Laboratory

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program
Interdisciplinary Graduate Program in Human Toxicology
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between ROS-signaling and other aspects of intracellular signaling networks. Research efforts are concentrated in identifying the molecular mechanisms involved in the regulation of the redox-sensitive G1-checkpoint following mitogenic stimuli and in asynchronously growing exponential cells. The possible role of ROS and thiol-redox reactions in regulating expression and activities of cyclins, CDKs, CKIs, CDC25, Rb, thioredoxin, and glutaredoxin are of immediate interest. Research efforts are also ongoing identifying the cellular effects of environmental pollutants, polychlorinated biphenyls. The possible role of oxidative stress in PCB-induced DNA damage, perturbation in cellular proliferation, and cell death is currently being investigated. Additional research interest includes investigating the possible role of intracellular redox environment in wound healing, radiosensitivity, radiation-induced cell cycle checkpoint pathways, and post-transcriptional gene regulation. The knowledge gained from these research projects may provide novel insights into the regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to devise better treatment protocols based on redox control of the cell cycle.

Selected Publications

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Xiao W, Sarsour E, Wagner B, Doskey C, Buettner G, Domann F, Goswami P.  Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.  Arch Toxicol.  2014 November 23. 

Date Last Modified: 06/06/2016 - 13:17:48