Curt D. Sigmund, PhD


Chair and Department Executive Officer
Roy J Carver Chair in Hypertension Research
Professor of Pharmacology
Professor of Internal Medicine, Molecular Physiology and Biophysics

Contact Information

Primary Office: 2-471B-1 Bowen Science Building
51 Newton Road
Iowa City, IA 52242
Phone: 319-335-7946

Lab: 2-340 Bowen Science Building
Iowa City, IA 52242
Phone: 319-335-8926

Web: Sigmund Laboratory


BA, Biology, State University of New York at Buffalo
MA, Biology, State University of New York at Buffalo
PhD, Molecular Biology, The State University of New York at Buffalo

Fellowship, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY

Education/Training Program Affiliations

Department of Pharmacology Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Dr. Sigmund's research interests focus on mechanisms of blood pressure regulation by the renin-angiotensin system and the transcription factor PPAR-γ. He utilizes a combination of molecular biological, genetic and physiological approaches in his research. Dr. Sigmund addresses many hypotheses with the generation of unique transgenic and knockout models of cardiovascular diseases including hypertension and arteriosclerosis.

Center, Program and Institute Affiliations

UIHC Center for Hypertension Research

Selected Publications

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Prasad A, Nuno D, Koval O, ketsawatsomkron P, Li W, Shen F, Joiner J, Kutschke W, Weiss R, Sigmund C, Anderson M, Lamping K, Grumbach I.  Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II..  Hypertension.  2013 August. 62(2):434-41.

Park S, Lu K, Liu X, Chatterjee T, Rudich S, Weintraub N, Kwitek A, Sigmund C.  Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue..  Hypertension.  2013 July. 62(1):41-7.

Littlejohn N, Siel Jr. R, Ketsawatsomkron P, Pelham C, Pearson N, Hilzendeger A, Buehrer B, Weidemann B, Li H, Davis D, Thompson A, Liu X, Cassell M, Sigmund C, Grobe J.  Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent..  Am J Physiol Regul Integr Comp Physiol.  2013 May 15. 304(10):R818-28.

Pelham C, Keen H, Lentz S, Sigmund C.  Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle..  Am J Physiol Regul Integr Comp Physiol.  2013 May 1. 304(9):R690-701.

Sigmund C.  A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system..  Arterioscler Thromb Vasc Biol.  2013 April. 33(4):676-8.

Hilzendeger A, Cassell M, Davis D, Stauss H, Mark A, Grobe J, Sigmund C.  Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension..  Hypertension.  2013 March. 61(3):716-22.

Quelle F, Sigmund C.  PPARγ: no SirT, no service..  Circulation Research.  2013 February 1. 112(3):411-4.

Grobe J, Rahmouni K, Liu X, Sigmund C.  Metabolic rate regulation by the renin-angiotensin system: brain vs. body..  Pflugers Archiv - European J of Physiol.  2013 January. 465(1):164-75.

Ketsawatsomkron P, Lorca R, Keen H, Weatherford E, Liu X, Pelham C, Grobe J, Faraci F, England S, Sigmund C.  PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity..  Circulation Research.  2012 November 9. 111(11):1446-58.

Pelham C, Ketsawatsomkron P, Groh S, Grobe J, de Lange W, Ibeawuchi S, keen H, Weatherford E, Faraci F, Sigmund C.  Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase..  Cell Metabolism.  2012 October 3. 16(4):462-72.

Date Last Modified: 06/06/2016 - 13:17:48