Matthew J. Potthoff, PhD


Assistant Professor of Pharmacology

Contact Information

Primary Office: 3322 Pappajohn Biomedical Discover Building
Iowa City, IA 52242
Phone: 319-384-4438

Lab: 3322 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242
Phone: 319-335-7660

Web: Potthoff Laboratory Website


BS, Suma Cum Laude, Biology / Zoology, University of Oklahoma
PhD, Genetics and Development, University of Texas Southwestern Medical Center

Fellowship, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology

Research Summary

Nutrient Control of Hepatic Metabolism and Signaling

The regulation of metabolic homeostasis is a complex process coordinated by numerous growth factors and hormones signaling the availability of energy and nutrients. While it is well known that the liver functions to maintain energy homeostasis by producing energy sources for other cells during nutrient deprivation, the liver is also becoming recognized as a major regulator of systemic energy metabolism through production of hepatokines. These liver derived hormones signal nutrient availability to other tissues and control substrate utilization to maintain energy balance. My lab is interested in unraveling these hepatic pathways that govern systemic energy balance by focusing on known and novel hepatokines. The purpose is two-fold: 1) secreted factors are a rich source of new therapeutics because they are designed to circulate and signal, and 2) nutrient signaling is dysregulated in several diseases including diabetes and cancer. To identify and examine hepatokine function, my lab integrates biochemistry, proteomics, cell biology, metabolomics, and mouse genetics. By unraveling these liver-derived networks, we hope to identify a new therapeutic to treat obesity and metabolic disease.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Fraternal Order of Eagles Diabetes Research Center

All Publications

von Holstein-Rathlou S, BonDurant L, Peltekian L, Naber M, Yin T, Claflin K, Ibarra Urizar A, Madsen A, Ratner C, Holst B, Karstoft K, Vandenbeuch A, Anderson C, Cassell M, Thompson A, Solomon T, Rahmouni K, Kinnamon S, Pieper A, Gillum M, Potthoff M.  FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.  Cell Metabolism.  2015 December. 

Markan K, Potthoff M.  Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.  Semin Cell Dev Biol .  2015 September 30. 

McGlashon J, Gorecki M, Kozlowski A, Thimbeck C, Markan K, Leslie K, Kotas M, Potthoff M, Richerson G, Gillum M.  Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.  Cell Metabolism.  2015. 21(5):692-705.

Gray L, Sultana M, Rauckhorst A, Oonthonpan L, Tompkins S, Sharma A, Fu X, Miao R, Pewa A, Brown K, Lane E, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris A, Cox J, Burgess S, Potthoff M, Taylor E.  Hepatic Mitochondrial Pyruvate Carrier 1 is Required for Efficient Regulation of Gluconeogenesis and Whole-body Glucose Homeostasis.  Cell Metabolism.  2015. 22(4):669-81.

Gray L, Sultana M, Rauckhorst A, Oonthonpan L, Tompkins S, Sharma A, Fu X, Miao R, Pewa A, Brown K, Lane E, Dohlman A, Zepeda-Orozco D, Xie J,  J, Norris A, Cox J, Burgess S, Potthoff M, Taylor E.  Hepatic Mitochondrial Pyruvate Carrier 1 is Required for Efficient Regulation of Gluconeogenesis and Whole-body Glucose Homeostasis.  Cell Metabolism.  2015. 22(4):669-681.

Markan K, Naber M, Ameka M, Anderegg M, Mangelsdorf D, Kliewer S, Mohammadi M, Potthoff M.  Circulating FGF21 is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding.  Diabetes.  2014. 63(12):4057-4063.

Potthoff M, Potts A, He T, Duarte J, Taussig R, Mangelsdorf D, Kliewer S, Burgess S.  Colesevelam Suppresses Hepatic Glycogenolysis by TGR5-mediated Induction of GLP-1 Action in DIO Mice.  Am J Physiol: Gastrointestinal and Liver Physiol.  2013 February. 304(4):G371-G380.

Potthoff M, Kliewer S, Mangelsdorf D.  Endocrine Fibroblast Growth Factors 15/19 and 21: From Feast to Famine.  Genes Dev.  2012 February 15. 26(4):312-324.

Zhang Y, Xie Y, Berglund E, Coate K, He T, Katafuchi T, Xiao G, Potthoff M, Wei W, Wan Y, Yu R, Evans R, Kliewer S, Mangelsdorf D.  The Starvation Hormone, Fibroblast Growth Factor-21, Extends Lifespan in Mice.  elife.  2012. 1:e00065.

Potthoff M, Boney-Montoya J, Choi M, Satapati S, He T, Suino-Powell K, Xu H, Gerard R, Finck B, Burgess S, Mangelsdorf D, Kliewer S.  FGF15/19 Regulates Hepatic Glucose Metabolism By Inhibiting the CREB-PGC-1α Pathway.  Cell Metabolism.  2011. 13(6):729-738.

Moresi V, Williams A, Meadows E, Flynn J, Potthoff M, McAnally J, Shelton J, Backs J, Klein W, Richardson J, Bassel-Duby R, Olson E.  Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases.  Cell.  2010 October 1. 143(1):35-45.

Sunny N, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff M, Browning J, Burgess S.  Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.  Am J Physiol Endocrinol Metab.  2010 June. 298(6):E1226-E1235.

Potthoff M, Inagaki T, Boney-Montoya J, Ding X, He T, Finck B, Mangelsdorf D, Burgess S, Kliewer S.  “FGF15/19 and FGF21 Govern Fed and Fasted Responses in Liver Through Reciprocal Regulation of PGC-1α.”.  Deuel Lipid Conference 2010. Dana Point, CA.  2010 March. 

Potthoff M, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck B, Mangelsdorf D, Kliewer S, Burgess S.  FGF21 Induces PGC-1alpha and Regulates Carbohydrate and Fatty Acid Metabolism During the Adaptive Starvation Response.  Proc Natl Acad Sci U S A.  2009 June 30. 106(26):10853-10858.

Satapati S, He T, Inagaki T, Potthoff M, Merritt M, Esser V, Mangelsdorf D, Kliewer S, Browning J, Burgess S.  Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.  Diabetes.  2008 August. 57(8):2012-2021.

Potthoff M, Wu H, Arnold M, Shelton J, Backs J, McAnally J, Richardson J, Bassel-Duby R, Olson E.  Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.  J Clin Invest.  2007 September. 117(9):2459-2467.

Montgomery R, Davis C, Potthoff M, Haberland M, Fielitz J, Qi X, Hill J, Richardson J, Olson E.  Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.  Genes Dev.  2007 July 15. 21(14):1790-1802.

Potthoff M, Wu H, Arnold M, Shelton J, Backs J,  J, Richardson J, Bassel-Duby R, Olson E.  Histone Deacetylase Degradation and MEF2 Activation Promote the Formation of Slow-twitch Myofibers.  J Clin Invest.  2007. 117(9):2459-2467.

Potthoff M, Wu H, Arnold M, Shelton J, Backs J, McAnally J, Bassel-Duby R, Olson E.  "Regulation of Skeletal Myofiber Identity by Selective Degradation of Class II HDACs.".  Symposium on Biological Complexity: Diseases of Transcription, Salk Institute, La Jolla, CA.  2007 January. 

Date Last Modified: 06/06/2016 - 13:17:48