Anne E. Kwitek, PhD


Associate Director, Iowa Institute of Human Genetics
Associate Professor of Pharmacology
Associate Professor of Internal Medicine

Contact Information

Primary Office: 2-252 Bowen Science Building
Iowa City, IA 52242
Phone: 319-384-2934

Lab: 2-200 Bowen Science Building
Iowa City, IA 52242
Phone: 319-335-6887

Web: Research at Iowa: Research Minute - Genetics


BS, University of Wisconsin at Stevens Point
PhD, Genetics, University of Iowa

Education/Training Program Affiliations

Department of Pharmacology Graduate Program
Interdisciplinary Graduate Program in Genetics
Medical Scientist Training Program

Research Summary

Dr. Kwitek is an animal and human geneticist whose research revolves around dissecting the genetic components of complex disease in rat and human, with an emphasis on hypertension, diabetes, and the metabolic syndrome. Her use of genome-wide approaches such as QTL mapping, comparative genomics, transcriptomics, and high-throughput genotyping has led to the identification of loci and genes involved in diabetes and cardiovascular disease in both rat models and human populations. Her current work is focused on combining traditional positional cloning approaches with, functional genomics and in silico mapping strategies to identify genes and pathways involved in the Metabolic Syndrome.

Center, Program and Institute Affiliations

Cardiovascular Research Center
Environmental Health Sciences Research Center
Fraternal Order of Eagles Diabetes Research Center
Iowa Initiative in Human Genetics
UI Obesity Research and Education Initiative
UIHC Center for Hypertension Research

Selected Publications

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Brownstein C, Beggs A, Homer N, Merriman B, Yu T, Kwitek A, Samuels M, Schwartzentruber J, Kohane I, Margulies D.  An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.  Genome Biology.  2014 March 25. 15(3):R53.

Ma M, Atanur S, Aitman T, Kwitek A.  Genomic Structure of Nucleotide Diversity among Lyon Rat Models of Metabolic Syndrome.  BMC Genomics.  2014 March 14. 15(1):197.

Atanur S, Diaz A, Maratou K, Sarkis A, Rotival M, Game L, Tschannen M, Kaisaki P, Otto G, Ma M, Keane T, Hummel O, Saar K, Chen W, Guryev V, Gopalakrishnan K, Garrett M, Joe B, Citterio L, Bianchi G, McBride M, Dominiczak A, Adams D, Serikawa T, Flicek P, Cuppen E, Hubner N, Petretto E, Gauguier D, Kwitek A, Jacob H, Aitman T.  Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat..  Cell.  2013 August. 154(3):691-703.

Park S, Lu K, Liu X, Chatterjee T, Rudich S, Weintraub N, Kwitek A, Sigmund C.  Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue..  Hypertension.  2013 July. 62(1):41-7.

Runge C, McNally M, Erbe C, Friedland D, Kwitek A, Kerschner J.  A Novel Otoferlin Splice-Site Mutation in Siblings with Auditory Neuropathy Spectrum Disorder.  Audiology and Neurotology.  2013. 18(6):374-382.

Moralejo D, Hansen C, Treuting P, Hessner M, Fuller J, Van Yserloo B, Jensen R, Osborne W, Kwitek A, Lernmark A.  Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats..  Physiological genomics.  2010 March. 41(1):9-20.

Fuller J, Bogdani M, Tupling T, Jensen R, Pefley R, Manavi S, Cort L, Blankenhorn E, Mordes J, Lernmark A, Kwitek A.  Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene..  Physiological genomics.  2009 June. 38(1):89-97.

Gilibert S, Bataillard A, Nussberger J, Sassard J, Kwitek A.  Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats..  Journal of hypertension.  2009 June. 27(6):1186-93.

Aitman T, Critser J, Cuppen E, Dominiczak A, Fernandez-Suarez X, Flint J, Gauguier D, Geurts A, Gould M, Harris P, Holmdahl R, Hubner N, Izsvak Z, Jacob H, Kuramoto T, Kwitek A, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull J, Szpirer C, Twigger S, Voigt B, Worley K.  Progress and prospects in rat genetics: a community view..  Nature genetics.  2008 May. 40(5):516-22.

Gilibert S, Kwitek A, Hubner N, Tschannen M, Jacob H, Sassard J, Bataillard A.  Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat..  Physiological genomics.  2008 April. 33(2):212-7.

Date Last Modified: 06/06/2016 - 13:17:48