Justin L. Grobe, PhD


Assistant Professor of Pharmacology

Contact Information

Primary Office: 2-307 Bowen Science Building
51 Newton Rd.
Iowa City, IA 52242
Phone: 319-353-5789

Lab: 2-300 Bowen Science Building
51 Newton Rd.
Iowa City, IA 52242
Phone: 319-353-5803

Web: Department of Pharmacology
Web: Grobe Laboratory Website


BA, Chemistry, Hope College, Holland, MI
BS, Biology, Hope College, Holland, MI
PhD, Pharmacodynamics, University of Florida, Gainesville, FL

Fellowship, University of Florida, Physiology and Functional Genomics, Gainesville, FL
Fellowship, University of Iowa, Internal Medicine, Iowa City, IA

Licensure and Certifications

Fellow of the American Heart Association (FAHA)

Education/Training Program Affiliations

Department of Pharmacology Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Medical Scientist Training Program

Research Summary

My laboratory is generally focused on understanding neural control of cardiovascular and metabolic function. We employ a wide range of pharmacological and physiological methods, along with new genetically-modified animal models of health and disease. Please see our laboratory website to learn about ongoing projects.

Center, Program and Institute Affiliations

Cardiovascular Research Center
Fraternal Order of Eagles Diabetes Research Center
UI Obesity Research and Education Initiative
UIHC Center for Hypertension Research

Selected Publications

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Weidemann B, Voong S, Morales-Santiago F, Kahn M, Ni J, Littlejohn N, Claflin K, Burnett C, Pearson N, Lutter M, Grobe J.  Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System.  Scientific Reports.  2015 June 11. 5:11123.

Claflin K, Grobe J.  Control of energy balance by the brain renin-angiotensin system.  Current hypertension reports.  2015 May 1. 17(5):38.

Sandgren J, Scroggins S, Santillan D, Devor E, Gibson-Corley K, Pierce G, Sigmund C, Santillan M, Grobe J.  Vasopressin: The Missing Link for Preeclampsia?.  American journal of physiology. Regulatory, integrative and comparative physiology.  2015 March 25. 

Santillan M, Santillan D, Scroggins S, Min J, Sandgren J, Pearson N, Leslie K, Hunter S, Zamba G, Gibson-Corley K, Grobe J.  Vasopressin in Preeclampsia: A Novel Very-Early Human Pregnancy Biomarker and Clinically-Relevant Mouse Model.  Hypertension.  2014 October. 64(4):852-859.

Burnett C, Grobe J.  Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry.  Molecular Metabolism.  2014. 3:460-464.

Burnett C, Grobe J.  Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice.  Am J Physiol: Endocrinol Metab.  2013 October 1. 305(7):E916-E924.

Littlejohn N, Siel Jr. R, Ketsawatsomkron P, Pelham C, Pearson N, Hilzendeger A, Buehrer B, Weidemann B, Li H, Davis D, Thompson A, Liu X, Cassell M, Sigmund C, Grobe J.  Hypertension in Mice with Transgenic Activation of the Brain Renin-Angiotensin System is Vasopressin-Dependent.  Am J Physiol: Regul Integr Comp Physiol.  2013 May 15. 304(10):R818-R828.

Hilzendeger A, Morgan D, Brooks L, Dellsperger D, Liu X, Grobe J, Rahmouni K, Sigmund C, Mark A.  A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.  Am J Physiol Heart Circ Physiol.  2012 July 15. 303(2):H197-H206.

Grobe J, Buehrer B, Hilzendeger A, Liu X, Davis D, Xu D, Sigmund C.  Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice.  Hypertension.  2011 March. 57[Part 2}(3):600-607.

Grobe J, Grobe C, Beltz T, Westphal S, Morgan D, Xu D, de Lange W, Li H, Sakai K, Thedens D, Cassis L, Rahmouni K, Mark A, Johnson A, Sigmund C.  The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.  Cell Metabolism.  2010 November 3. 12(5):431-442.

Date Last Modified: 06/06/2016 - 13:17:48