Stead Family Department of Pediatrics

Val Sheffield, MD, PhD


The Carver Chair in Molecular Genetics
Investigator, Howard Hughes Medical Institute
Director, Division of Medical Genetics
Director, Interdepartmental Research Program in Human Molecular Genetics
Professor of Pediatrics  - Medical Genetics
Professor of Ophthalmology and Visual Sciences

Contact Information

Lab: 4181 MERF
Iowa City, IA 52242
Phone: 319-335-6898

Web: UI Clinical Profile


BS, Zoology, Brigham Young University
MS, Developmental Biology, Brigham Young University
PhD, Developmental Biology, University of Chicago
MD, Medicine, with Honors, University of Chicago

Residency, Pediatrics, University of California, San Francisco
Fellowship, Medical Genetics, University of California, San Francisco

Licensure and Certifications

Board certified in Clinical Medical Genetics
Diplomate of the National Board of Medical Examiners
Permanent Iowa license to practice medicine and surgery
Board certified in Clinical Molecular Genetics

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

My laboratory is interested in identifying and understanding the function of genes which cause a variety of human disorders. Our research efforts have focused on the molecular genetics of monogenic disorders, as well as polygenic and multifactorial disorders. Our research efforts have resulted in the mapping of many different disease loci. In addition, we have used positional cloning methods to identify genes involved in a number of different diseases including hereditary blindness and deafness. Efforts are currently underway to use positional cloning strategies to identify additional disease-causing genes. Complex genetic disorders currently under investigation in the laboratory include hypertension, obesity, congenital heart disease and autism. In addition, we have worked on developing and improving techniques for disease mapping, positional cloning, and mutation detection. We have also had an active role in the human genome project and the rat genome project.

Date Last Modified: 10/13/2016 - 12:48:06