Thomas J. Waldschmidt, PhD


Clement T. and Sylvia H. Hanson Chair in Immunology
Vice Chair for Research
Director, Department of Pathology Graduate Program
Professor of Pathology

Contact Information

Primary Office: 1038 Medical Laboratories
Iowa City, IA 52242
Phone: 319-335-8223

Web: Dr. Waldschmidt's Research Laboratory


BS, Biology, Marquette University, Milwaukee, WI
PhD, Immunology, University of Texas Southwestern Medical Center, Dallas, TX

Fellowship, Cancer Immunology Training Program, UT Southwestern
Fellowship, Robert A. Welch Foundation, UT Southwestern
Post Doctorate, University of Iowa College of Medicine, Iowa City, IA

Education/Training Program Affiliations

Department of Pathology Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Role of B lymphocyte subsets in humoral immunity, germinal center biology, effect of chronic alcohol exposure on B cell function.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Selected Publications

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Boyden A, Legge K, Waldschmidt T.  Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses.  PloS one.  2012. 7(7):e40733.

Butler N, Moebius J, Pewe L, Traore B, Doumbo O, Tygrett L, Waldschmidt T, Crompton P, Harty J.  Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.  Nature immunology.  2012. 13(2):188-95.

Fan J, Edsen-Moore M, Turner L, Cook R, Legge K, Waldschmidt T, Schlueter A.  Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.  Alcoholism, clinical and experimental research.  2011. 35(1):47-59.

Alexander C, Tygrett L, Boyden A, Wolniak K, Legge K, Waldschmidt T.  T regulatory cells participate in the control of germinal centre reactions.  Immunology.  2011. 133(4):452-68.

Langlois R, Meyerholz D, Coleman R, Cook R, Waldschmidt T, Legge K.  Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice.  Alcoholism, clinical and experimental research.  2010. 34(8):1425-31.

Lu P, Hankel I, Knisz J, Marquardt A, Chiang M, Grosse J, Constien R, Meyer T, Schroeder A, Zeitlmann L, Al-Alem U, Friedman A, Elliott E, Meyerholz D, Waldschmidt T, Rothman P, Colgan J.  The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.  The Journal of experimental medicine.  2010. 207(7):1359-67.

McGill J, Meyerholz D, Edsen-Moore M, Young B, Coleman R, Schlueter A, Waldschmidt T, Cook R, Legge K.  Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.  Journal of immunology.  2009. 182(12):7803-8.

Verma S, Waldschmidt T.  Characterization of splenic CD21hi T2 B cells.  Immunologic research.  2007. 39(3-Jan):240-8.

Cook R, Schlueter A, Coleman R, Tygrett L, Ballas Z, Jerrells T, Nashelsky M, Ray N, Haugen T, Waldschmidt T.  Thymocytes, pre-B cells, and organ changes in a mouse model of chronic ethanol ingestion--absence of subset-specific glucocorticoid-induced immune cell loss.  Alcoholism, clinical and experimental research.  2007. 31(10):1746-58.

Wolniak K, Noelle R, Waldschmidt T.  Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice.  Journal of immunology.  2006. 177(4):2072-9.

Date Last Modified: 09/22/2016 - 07:05:39