Steven A. Moore, MD, PhD


Director of Neuropathology
Co-Director, Wellstone Muscular Dystrophy Cooperative Research Center
Professor of Pathology  - Anatomic and Clinical Pathology

Contact Information

Primary Office: 5239B Roy Carver Pavilion
Iowa City, IA 52242
Phone: 319-384-9084

Lab: 4270A Carver Biomedical Research Building
Iowa City, IA 52242
Phone: 319-335-8215

Web: Muscular Dystrophy Diagnostic Service
Web: Dr. Moore's Research Laboratory


BS, Purdue University
PhD, Anatomy, Indiana University
MD, Indiana University School of Medicine

Residency, Pathology, University of Iowa College of Medicine
Fellowship, Neuropathology, University of Iowa College of Medicine

Licensure and Certifications

Anatomic Pathology, American Board of Pathology
Neuropathology, American Board of Pathology
State of Iowa Medical License, Iowa Board of Medicine

Education/Training Program Affiliations

Department of Pathology Graduate Program
Interdisciplinary Graduate Program in Neuroscience

Research Summary

Muscular dystrophies are a diverse group of inherited disorders characterized by progressive muscle weakness and wasting. Dr. Moore is involved in the evaluation of patient biopsies and in research partially funded through a center grant from NIH. This Paul D. Wellstone Muscular Dystrophy Cooperative Research Center is exploring therapeutic strategies for the treatment of various muscular dystrophies by enabling translational research on muscular dystrophies and providing advanced diagnostic services. The MDCRC is composed of two research projects, three cores and investigators with a proven track record of excellence and collaboration. The Center researchers' studies and facilities will explore basic biological mechanisms that relate to possible treatments for muscular dystrophies, facilitate translational research on muscular dystrophies and provide advanced diagnostic services to patients and clinical trial participants. The Director and Co-director, Kevin Campbell and Steven Moore, are investigators with established records in basic, translational, and clinical research on muscular dystrophy.

Additional basic science collaboration with Dr. Kevin Campbell, Department of Molecular Physiology and Biophysics ( The Laboratory of Dr. Kevin P. Campbell) involves the pathologic characterization of genetic mouse models of muscular dystrophy. Many of these models use Cre-lox methodology to selectively knock out brain or peripheral nerve dystroglycan. These mice model congenital muscular dystrophy. A second basic science collaboration is with Lori Wallrath (Department of Biochemistry, The University of Iowa) studying lamin A/C.

Including the Wellstone MDCRC mentioned above, clinical diagnostic work in the general area of muscular dystophies has expanded into basic and clinical research projects in collaboration with several physicians at other institutions, Kevin Campbell, and Kathy Mathews (Department of Pediatrics, The University of Iowa). Current clinical studies involve: (1) a natural history study of patients with dystroglycanopathy, (2) a search for new genes in congenital myopathy and muscular dystrophy patients, (3) dysferlinopathy patients with amyloid deposition, (4) autophagic vacuolar myopathy patients, and (5) improvements in diagnostic testing.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center

Selected Publications

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Lawlor M, Beggs A, Buj-Bello A, Childers M, Dowling J, James E, Meng H, Moore S, Prasad S, Schoser B, Sewry C.  Skeletal Muscle Pathology in X-Linked Myotubular Myopathy: Review With Cross-Species Comparisons .  J Neuropathol Exp Neurol;  2016. 

Jensen B, Willer T, Saade D, Cox M, Mozaffar T, Scavina M, Steffans V, Winder T, Campbell K, Moore S, Mathews K.  Gmppb-Associated Dystroglycanopathy: Emerging Common Variants with Phenotype Correlation.  Hum Mutat.  2015 August 27. 

Jerath N, Crockett C, Moore S, Shy M, Weihl C, Chou T, Grider T, Gonzalez M, Zuckner S, Swenson A.  Rare manifestation of a c.290C>T, p.Gly97Glu VCP mutation.  Case Reports Genet.  2015 March 23. 2015.

Bharucha-Goebel D, Neil E, Donkervoort S, Dastgir J, Wiggs E, Winder T, Moore S, Iannaccone S, Bonnemann C.  Intrafamilial variability in GMPPB associated dystroglycanopathy: broadening the clinical phenotype.  Neurology;  2015. 

Crockett C, Bertrand L, Cooper C, Rahhal R, Liu K, Zimmerman M, Moore S, Mathews K.  Urologic and gastrointestinal symptoms in the dystroglycanopathies.  Neurology;  2015. 

Tsuda T, Fitzgerald K, Scavena m, Gidding S, Cox M, Marks H, Flanigan K, Moore S.  Early-progressive dilated cardiomyopathy in a family with Becker muscular dystrophy related to a novel frameshift mutation in the dystrophin gene exon 27.  J Hum Genet;  2015. 

Sanmaneechai O, Swenson A, Gerke A, Moore S, Shy M.  Inclusion body myositis with sarcoidosis: A case report.  Neuromuscul Disord.  2015. 25:297-300.

Al-Zaidy S, Malik V, Kneile K, Rosales X, Gomez A, Lewis S, Gastier-Foster J, Kang P, Darras B, Kunkel L, Carlo J, SAhenk Z, Moore S, Pyatt R, Mendell J.  Slowly progressive limb-girdle muscular dystrophy type 2C associated with founder mutation in the SGCG gene in Puerto Rican Hispanics.  Mol Genet Genomic Med.  2015. 3:92-98.

Dowling J, Moore S, Kalimo H, Minassian B.  X-linked autophagic vacuolar myopathy: a failure of self eating.  Acta Neuropathol.  2015. 129:383-390.

Khoo M, Hebbar S, Zhao W, Moore S, Oberley L, Domann F, Robbins M.  Differential Activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy.  Redox Biology.  2013 January 26. 1(1):70-79.

Date Last Modified: 09/22/2016 - 07:07:20