Michael Knudson, MD, PhD


Medical Director of the Blood Bank and Donor Collections, DeGowin Blood Center
Clinical Associate Professor of Pathology  - Transfusion Medicine
Clinical Associate Professor of Radiation Oncology

Contact Information

Primary Office: SW247 General Hospital
Iowa City, IA 52242
Phone: 319-337-5129



BS, The University of Iowa, Iowa City, IA
MD, The University of Iowa, Iowa City, IA
PhD, The University of Iowa, Iowa City, IA

Residency, Laboratory Medicine, Washington University Medical Center, Department of Pathology

Licensure and Certifications

Clinical Pathology, American Board of Pathology
State of Iowa Medical License, Iowa Board of Medicine

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Role of Bcl-2 family members in cell cycle control and apoptosis, and their role in oncogenesis.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Selected Publications

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Zagorodna O, Martin S, Rutkowski D, Kuwana T, Spitz D, Knudson M.  2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines.  Oncogene.  2012 May. 31(22):2738-49.

Wang S, Martin S, Harris P, Knudson M.  Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma.  PloS one.  2011. 6(5):e19786.

van de Wetering C, Coleman M, Spitz D, Smith B, Knudson M.  Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.  Free radical biology & medicine.  2008 April. 44(8):1677-86.

Cheng N, van de Wetering C, Knudson M.  p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.  PloS one.  2008. 3(4):e1911.

van de Wetering C, Horne M, Knudson M.  Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma.  Cancer research.  2007 September. 67(17):8081-8.

Brown N, Martin S, Maurice N, Kuwana T, Knudson M.  Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells.  The Journal of biological chemistry.  2007 January. 282(4):2144-55.

Cheng N, Janumyan Y, Didion L, Van Hofwegen C, Yang E, Knudson M.  Bcl-2 inhibition of T-cell proliferation is related to prolonged T-cell survival.  Oncogene.  2004 May. 23(21):3770-80.

Luke J, Van De Wetering C, Knudson M.  Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability.  Cell death and differentiation.  2003 June. 10(6):740-8.

Knudson M, Johnson G, Lin Y, Korsmeyer S.  Bax accelerates tumorigenesis in p53-deficient mice.  Cancer research.  2001 January. 61(2):659-65.

Knudson M, Tung K, Tourtellotte W, Brown G, Korsmeyer S.  Bax-deficient mice with lymphoid hyperplasia and male germ cell death.  Science (New York, N.Y.).  1995 October. 270(5233):96-9.

Date Last Modified: 08/02/2016 - 10:11:59