David Meyerholz, DVM, PhD


Director, Division of Comparative Pathology
Associate Professor of Pathology

Contact Information

Primary Office: 1165 Medical Laboratories
Iowa City, IA 52242

Web: Division of Comparative Pathology


DVM, Iowa State University
MS, Iowa State University
PhD, Iowa State University

Residency, Veterinary Pathology, Iowa State University

Licensure and Certifications

Diplomate, American College of Veterinary Microbiologists (Virology)
Diplomate, American College of Veterinary Pathologists

Research Summary

Dr. Meyerholz studies cystic fibrosis (CF), a genetic condition cause by mutations in CFTR gene. Goals of his research are to define the molecular origins of CF disease, identify new biomarkers and evaluate novel treatments. He also has research interests in diseases of the lung (e.g. influenza, MERS-CoV, RSV, SARS-CoV) as well as comparative pathology, cardiovascular disease, cancer and neurofibromatosis-1. Dr. Meyerholz has published >135 peer-reviewed papers in scientific journals.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Center for Immunology and Immune-based Diseases
Cystic Fibrosis Research Center
Institute for Clinical and Translational Science

Selected Publications

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Shah V, Meyerholz D, Tang X, Reznikov L, Abou Alaiwa M, Ernst S, Karp P, Wohlford-Lenane C, Heilmann K, Leidinger M, Allen P, Zabner J, McCray, Jr P, Ostedgaard L, Stoltz D, Randak C, Welsh M.  Airway acidification initiates host defense abnormalities in cystic fibrosis mice..  Science (New York, N.Y.).  2016. 351(6272):503-7.

Zhao J, Zhao J, Mangalam A, Channappanavar R, Fett C, Meyerholz D, Agnihothram S, Baric R, David C, Perlman S.  Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses..  Immunity.  2016. 44(6):1379-91.

Cook D, Rector M, Bouzek D, Michalski A, Gansemer N, Reznikov L, Li  X, Stroik M, Ostedgaard L, Abou Alaiwa M, Thompson M, Prakash Y, Krishnan R, Meyerholz D, Seow C, Stoltz D.  CFTR in Sarcoplasmic Reticulum of Airway Smooth Muscle: Implications for Airway Contractility..  American journal of respiratory and critical care medicine.  2016. 193(4):417-26.

Channappanavar R, Fehr A, Vijay R, Mack M, Zhao J, Meyerholz D, Perlman S.  Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice..  Cell host & microbe.  2016. 19(2):181-93.

Meyerholz D, Lambertz A, Reznikov L, Ofori-Amanfo G, Karp P, McCray, Jr P, Welsh M, Stoltz D.  Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans..  Toxicologic pathology.  2016. 44(3):434-41.

Stoltz D, Meyerholz D, Welsh M.  Origins of Cystic Fibrosis Lung Disease.  The New England Journal of Medicine.  2015. 372(4):351-362.

Knudson C, Hartwig S, Meyerholz D, Varga S.  RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets.  PLoS pathogens.  2015. 11(3):e1004757.

Hernandez F, Huang L, Olson M, Powers K, Hernandez L, Meyerholz D, Thedens D, Behlke M, Horswill A, McNamara J.  Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.  Nature medicine.  2014. 20(3):301-306.

Adam R, Michalski  A, Bauer C, Abou Alaiwa  M, Gross T, Awadalla  M, Bouzek  D, Gansemer  N, Taft P, Hoegger  M, Diwakar  A, Ochs M, Reinhardt  J, Hoffman E, Beichel  R, Meyerholz D, Stoltz D.  Air trapping and airflow obstruction in newborn cystic fibrosis piglets.  American journal of respiratory and critical care medicine.  2013. 188(12):1434-41.

Klesney-Tait  J, Keck K, Li X, Gilfillan  S, Otero  K, Baruah  S, Meyerholz D, Varga S, Knudson C, Moninger  T, Moreland  J, Zabner J, Colonna M.  Transepithelial migration of neutrophils into the lung requires TREM-1.  Journal of Clinical Investigation.  2012. 123:138-149.

Date Last Modified: 09/30/2016 - 10:11:11