Carol J. Holman, MD, PhD


Director of Leukemia Pathology, Holden Comprehensive Cancer Center
Clinical Associate Professor of Pathology  - Clinical Pathology

Contact Information

Primary Office: 6229 Roy Carver Pavilion
Iowa City, IA 52242
Phone: 319-356-3981



PhD, Biochemistry, University of Illinois, Urbana-Champaign, IL
MD, University of Illinois, Urbana-Champaign, IL

Residency, Pathology, University of Minnesota
Fellowship, Hematopathology, University of Minnesota

Licensure and Certifications

State of Iowa Medical License,  Iowa Board of Medicine
Hematology, American Board of Pathology
Anatomic and Clinical Pathology, American Board of Pathology

Research Summary

Dr. Holman has broad interests in many areas of hematopathology, including clinical diagnosis of patients with leukemia and lymphoma, as well as optimal laboratory testing for detection of minimal residual disease following therapy. She has research interests in the pathogenesis of Epstein-Barr virus infection and its role in a variety of diseases including post-transplant lymphoproliferative disorder, lymphomatoid granulomatosis, and infectious mononucleosis.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Selected Publications

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Rosean T, Holman C, Tompkins V, Jing X, Krasowski M, Rose J, Janz S.  KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. .  Blood Cancer Journal.  2016 February 26. 

Han S, Tompkins V, Son D, Han S, Yun H, Kamberos N, Dehoedt C, Gu C, HolmN X, Tricot g, Zhan F, Janz S.  CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma.  Exp Hematol Oncol.  2015 March. 

Mettler T, Holman C, McKenna R, Pambuccian S.  Plasmablastic myeloma in ascitic fluid.  Diagn Cytopathol.  2012 June. 40(9):806-9.

Kaplan A, Samad A, Dolan M, Cioc A, Holman C, Schmechel S, Pambuccian S.  Follicular lymphoma transformed to "double-hit" B lymphoblastic lymphoma presenting in the peritoneal fluid.  Diag Cytopathol.  2012 May. 

Holman C, Karger A, Mullan B, Brundage R, Balfour H.  Quantitative Epstein-Barr virus shedding and its correlation with the risk of post-transplant lymphoproliferative disorder.  Clinical Transplant.  2012 March. 26(5):741-7.

Gleason M, Lenvik T, McCullar V, Felices M, O'Brien M, Cooley S, Verneris M, Cichocki F, Holman C, Panoskaltsis-Mortari A, Niki T, Hirashima M, Blazar B, Miller J.  Tim-3 enhances interferon gamma production in response to galectin-9 human natural killer cells.  Blood.  2012 March. 119(13):3064-72.

Wudhikarn K, Holman C, Linan M, Blaes A, Dunitz J, Hertz M, Peterson B.  Post-transplant lymphoproliferative disorders in lung transplant recipients: 20-yr experience at the University of Minnesota.  Clinical Transplant.  2011. 25(5):705-13.

Romain C, Balfour, Jr H, Vezina H, Holman C.  A method for evaluating antiviral drug susceptibility of Epstein-Barr virus.  Virus Adapt Treatment .  2010 January. 2:1-7.

Dunning K, Wudhikarn K, Safo A, Holman C, McKenna R, Pambuccian S.  Adrenal extranodal NK/T-cell lymphoma diagnosed by fine-needle aspiration and cerebrospinal fluid cytology and immunophenotyping: a case report.  Diagn Cytopathol.  2009 September. 37(9):686-95.

Balfour H, Hokanson K, Schacherer R, Fietzer C, Schmeling D, Holman C, Vezina H, Brundage R.  A virologic pilot study of valacyclovir in infectious mononucleosis.  Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology.  2007 May. 39(1):16-21.

Date Last Modified: 06/06/2016 - 13:17:48