Andrean Simons-Burnett, PhD


Assistant Professor of Pathology
Assistant Professor of Radiation Oncology

Contact Information

Primary Office: 1161 Medical Laboratories
Iowa City, IA 52242
Phone: 319-384-4450

Web: Dr. Simons-Burnett's Research Laboratory


Michigan Technology University
BS, Biochemistry, Iowa State University
PhD, Toxicology and Food Science and Technology, Iowa State University

Post Doctorate, Free Radical and Radiation Biology, University of Iowa, Carver College of Medicine

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Human Toxicology

Research Summary

Signaling pathways and oxidative stress in cancer progression.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Selected Publications

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Du J, Nelson E, Simons-Burnett A, Olney K, Moser J, Schrock H, Wagner B, Buettner G, Smith B, Teoh M, Tsao M, Cullen J.  Regulation of pancreatic cancer growth by superoxide.  Molecular carcinogenesis.  2013. 52(7):555-67.

Kang M, So E, Simons-Burnett A, Spitz D, Ouchi T.  DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.  Cell death & disease.  2012. 3:e249.

Sobhakumari A, Love-Homan L, Fletcher E, Martin S, Parsons A, Spitz D, Knudson C, Simons-Burnett A.  Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism.  PLoS One.  2012. 7(10):e48175.

Orcutt K, Parsons A, Sibenaller Z, Scarbrough P, Zhu Y, Sobhakumari A, Wilke W, Kalen A, Goswami P, Miller F, Spitz D, Simons-Burnett A.  Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.  Cancer research.  2011. 71(11):3932-40.

Mattson D, Ahmad I, Dayal D, Parsons A, Aykin-Burns N, Li L, Orcutt K, Spitz D, Dornfeld K, Simons-Burnett A.  Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism.  Free radical biology & medicine.  2009. 46(2):232-7.

Simons-Burnett A, Mattson D, Dornfeld K, Spitz D.  Glucose deprivation-induced metabolic oxidative stress and cancer therapy.  Journal of cancer research and therapeutics.  2009. 5 Suppl 1:S2-6.

Simons-Burnett A, Parsons A, Foster K, Orcutt K, Fath M, Spitz D.  Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells.  Journal of Oncology.  2009. 2009:519563.

Fath M, Diers A, Aykin-Burns N, Simons-Burnett A, Hua L, Spitz D.  Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells.  Cancer biology & therapy.  2009. 8(13):1228-36.

Simons-Burnett A, Ahmad I, Mattson D, Dornfeld K, Spitz D.  2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells.  Cancer research.  2007. 67(7):3364-70.

Simons-Burnett A, Fath M, Mattson D, Smith B, Walsh S, Graham M, Hichwa R, Buatti J, Dornfeld K, Spitz D.  Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging.  International journal of radiation oncology, biology, physics.  2007. 69(4):1222-30.

Date Last Modified: 06/06/2016 - 13:17:48