Ophthalmology And Visual Sciences

Young H. Kwon, MD, PhD


Clifford M. and Ruth M. Altermatt Professor of Glaucoma
Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 11190B  PFP
Iowa City, IA 52242
Phone: 319-356-3938

Email: young-kwon@uiowa.edu
Web: UI Clinical Profile


BS, Biology, Massachusetts Institute of Technology
MD, Yale University School of Medicine
PhD, Neuroscience, Massachusetts Institute of Technology

Internship, Internal Medicine, Mt Auburn Hospital, Harvard Medical School
Residency, Ophthalmology, Massachusetts Eye & Ear Infirmary
Fellowship, Glaucoma, Yale University School of Medicine

Licensure and Certifications

ABO Certification, American Board of Ophthalmology
NBME Diplomate, National Board of Medical Examinars
State of Iowa Medical License, Iowa Board of Medicine
Connecticut Medical License- Permanent (inactive)
Temporary Massachusetts Medical License (inactive)

Research Summary

Glaucoma is the second leading cause of blindness in the United States, but can be managed if diagnosed early and treated appropriately. Adequate diagnosis and treatment depends on measurement of changes in the optic nerve cupping. We have developed a novel computer software method to automatically measure the optic nerve changes from digital stereo optic nerve photographs. This image processing alogorithm is based on pixel feature classification algorithm, which has previously been developed for the purpose of evaluating diabetic retinopathy in digital fundus photographs. We have utilized novel, biologically plausible pixel feature classification algorithm to automatically segment the optic disc into cup and rim, and compared its performance to the reference standard, i.e., computer-assisted planimetry by human glaucoma experts. The early results are promising. We hope to eventually develop and refine the algorithm to objectively diagnose and detect progression of glaucomatous optic nerve cupping from serial digital stereo fundus photographs. Dr. Kwon is also interested in the education of public regarding glaucoma through free on- line publications. See www.medrounds.org/glaucoma-guide.

Center, Program and Institute Affiliations

Iowa Institute for Biomedical Imaging
Stephen A. Wynn Institute for Vision Research

Selected Publications

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Hazlewood R, Roos B, Solivan-Timpe F, Honkanen R, Jampol L, Gieser S, Meyer K, Mullins R, Kuehn M, Scheetz T, Kwon Y, Alward W, Stone E, Fingert J.  Heterozygous triplication of upstream regulatory sequences leads to dysregulation of matrix metalloproteinase 19 in patients with cavitary optic disc anomaly.  Human mutation.  2015 March 1. 36(3):369-78.

Bogunović H, Kwon Y, Rashid A, Lee K, Critser D, Garvin M, Sonka M, Abràmoff M.  Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma.  Investigative ophthalmology & visual science.  2014 December 9. 56(1):259-71.

Miri M, Lee K, Niemeijer M, Abramoff M, Kwon Y, Garvin M.  Multimodal segmentation of the optic disc and cup from stereo fundus and SD-OCT images .  Proceedings of SPIE Medical Imaging, Imaging Processing.  2013 February. 8669:8669-23.

Miri M, Abramoff M, Lee K, Niemeijer M, Wahle A, Kwon Y, Garvin M.  A multimodal Machine-Learning-Based Approach for Segmenting the Optic Disc and Cup in Fundus and SD-OCT Images.  Invest. Ophthalmol. Vis. Sci. Abstr..  2013. 

Lee K, Kwon Y, Abramoff M, Garvin M, Sonka M.  Correction of the retinal angle in SD-OCT of glaucomaatous eyes provides better reproducibility of optic nerve head parameters.  Invest. Ophthalmol. Vis. Sci. Abstr..  2013. 

Seo S, Sullivan-Timpe F, Roos B, Robin A, Stone E, Kwon Y, Alward W, Fingert J.  Identification of proteins that interact with Tank Binding Kinase 1 (TBK1) and testing for mutations associated with glaucoma.  Current Eye Res.  2013. 38(2):310-315.

Risma J, Alward W, Fingert J, Kwon Y.  Diaton Transpalpebral tonometry in patients with glaucoma and glaucoma drainage devices - A preliminary study for its use in keratoprosthesis patients.  Resident/Fellow Research Day, Department of Ophthalmology and Visual Sciences, University of Iowa.  2012 April. 

Tienor B, Abramoff M, Johnson C, Kwon Y.  Optic disc size in glaucoma patients with high myopia.  Resident/Fellow Research Day, Department of Ophthalmology and Visual Sciences, University of Iowa.  2012 April. 

Gauger E, Kwon Y, Mahajan V.  The effect of pars plana vitrectomy in patients with glaucoma.  Resident/Fellow Research Day, Department of Ophthalmology and Visual Sciences, University of Iowa.  2012 April. 

Wandling G, Rauen M, Goins K, Kitzmann A, Sutphin J, Kwon Y, Alward W, Wagoner M.  Glaucoma therapy escalation in eyes with pseudophakic corneal edema after penetrating keratoplasty and Descemet's stripping automated endothelial keratoplasty..  International ophthalmology.  2012 February. 32(1):14-Sep.

Date Last Modified: 10/13/2016 - 12:43:52