Obstetrics and Gynecology

Xiangbing Meng, PhD


Research Associate Professor of Obstetrics and Gynecology  - Reproductive Science Research

Contact Information

Primary Office: 3234 MERF
Iowa City, IA 52242
Phone: 319-335-8212

Email: xiangbing-meng@uiowa.edu


BS, Biochemistry, Beijing Normal University, China
MS, Biochemistry and Molecular Biology, Beijing Normal University, China
PhD, Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Academy of Military Medicine, Beijing, China

Post Doctorate, Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio
Post Doctorate, Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico

Research Summary

New prognosis biomarkers and potential therapeutic targets in gynecology; Synthetic lethal studies in gynecology; Mitotic Catastrophe induction in ovarian and endometrial cancer

All Publications

Meng X, Yang S, Zhang Y, Wang X, Goodfellow R, Jia Y, Thiel K, Reyes H, Yang B, Leslie K.  Genetic Deficiency of Mtdh in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.  J Biol Chm.  2015 March 18. 

Yang S, Jia Y, Liu X, Winters C, Wang X, Zhang Y, Devor E, Hovey A, Reyes H, Xiao X, Xu Y, Dai D, Meng X, Thiel K, Domann F, Leslie K.  Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer.  Oncotarget.  2014 October 30. 5(20):9783-97.

Meng X, Yang S, Zhang Y, Wang X, Jia Y, Yang B, Leslie K.  Role of oncogenic metadherin (Mtdh) at synaptic checkpoint of male mice.  2014 October. 

Meng X, Devor E, Yang S, Schickling B, Leslie K.  Role of MTDH, FOXM1 and microRNAs in Drug Resistance in Hepatocellular Carcinoma, Diseases.  Diseases.  2014 July 1. 2(3):209-225.

Meng X, Yang S, Wang X, Jia Y, Zhang Y, Leslie K.  Restoring sensitivity to cisplatin or TRAIL by targeting drug resistance master regulators in endometrial cancer.  2014 April. 

Yang S, Meng X.  Advances and Perspectives in the Treatment of High-Grade Serous Ovarian Cancer.  Journal of Women's Health and Gynecology.  2014 February 24. 1:1-3.

Meng X, Dizon D, Yang S, Wang X, Zhu D, Thiel T, Leslie K.  Strategies for molecularly enhanced chemotherapy to achieve synthetic lethality in endometrial tumors with mutant p53.  Obstet Gynecol Int 2013.  2013 December 7. 2013(828165).

Yang S, Leslie K, Meng X.  MTDH and FOXM1, Two Master Regulators in Gynecologic Cancer.  Med J Obstet Gynecol.  2013 September 2. 1(2):1009.

Meng X, Thiel K, Leslie K.  Drug Resistance Mediated by MTDH/AEG-1/Lyric, Advances in Cancer Research, 1st Edition, AEG-1/MTDH/Lyric Implicated in Multiple Human Cancers .  2013 August 12. 

Meng X, Yang S, Zhu D, Wang X, Thiel K, Leslie K.  Strategies for Molecularly Enhanced Chemotherapy in Endometrial Tumors with Mutant p53 (Poster).  104th American Association for Cancer Research (AACR) Annual Meeting.  2013 April 6. 

Yang S, Xiao X, Liu X, Jia Y, Zhang X, Devor E, Meng X, Thiel K, Leslie K.  Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells.  Curr Pharm Des. 2013 Jul 19. [Epub ahead of print].  2013. 

Meng X, Laidler L, Kosmacek E, Yang S, Xiong Z, Zhu D, Wang X, Dai D, Zhang Y, Wang X, Brachova P, Albitar L, Liu D, Ianzini F, Mackey M, Leslie K.  Induction of Mitotic Cell Death in Cancer Cells with Non-Functional p53: a New Therapeutic Strategy.  Gynecol Oncol .  2012 November 9. 128(3):461-9.

Meng X, Zhu D, Wang X, Yang S, Zhang Y, Xiong Z, Leslie K.  Identification of a Novel Cytoplasmic Role for MDTH in Chemoresistance as a RNA Binding Protein (Poster).  103rd American Association for Cancer Research (AACR) Annual Meeting.  2012 March 30. 

Meng X, Zhu D, Yang S, Wang X, Xiong Z, Zhang Y, Brachova P, Leslie K.  Cytoplasmic Metadherin (MTDH) Provides Survival Advantage Under Conditions of Stress by Acting as RNA-Binding Protein.  The Journal of Biological Chemistry.  2012 February. 287(7):4485-91.

Milhem M, Knutson T, Yang S, Zhu D, Wang X, Leslie K, Meng X.  Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients.  Journal of Cancer Science & Therapy.  2011 December. S5(4).

Meng X, Matlawska-Wasowska K, Girodon F, Mazel T, Willman C, Atlas S, Chen I, Harvey R, Hunger S, Ness S, Winter S, Wilson B.  GSI-I (Z-LLNle-CHO) Inhibits Gamma-Secretase and the Proteosome to Trigger Cell Death in Precursor-B Acute Lymphoblastic Leukemia.  Leukemia.  2011 July. 25(7):1135-46.

Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Leslie K.  Knockdown of MTDH Increases Drug Sensitivity to HDAC Inhibitor and TRAIL Combination Treatment in Endometrial Cancer Cells (Poster).  102nd American Association for Cancer Research (AACR) Annual Meeting.  2011 April 2. 

Yang S, Xiao X, Meng X, Leslie K.  A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors.  PloS One.  2011. 6(10):e26343.

Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Thiel K, Leslie K.  Knockdown of Metadherin Sensitizes Cell Death Receptor Ligand TRAIL and HDAC Inhibitor LBH589 Co-Treatment.  PLoS One.  2011. 6(6):e20920.

Meng X, Laidler L, Albitar L, Holmes A, Dai D, Buekers T, Bender D, Leslie K.  The Combination of Paclitaxel and Gefitinib (Iressa, ZD1839) Inhibits Endometrial Cancer Cells by Inducing Mitotic Catastrophe: Proof of Principle for Dual Therapy in Endometrial Cancer (Poster).  101st American Association for Cancer Research (AACR) Annual Meeting.  2010 April 17. 

Fan J, Wray J, Meng X, Shen Z.  BCCIP is Required for the Nuclear Localization of the p21 Protein.  Cell Cycle.  2009 September 15. 8(18):3019-24.

Meng X, Winter S, Martinez A, Wilson B.  IKK Inhibitor Bay 11-7082 Induces Necrotic Cell Death in Pre-B ALL Cells (Poster).  100th American Association for Cancer Research (AACR) Annual Meeting.  2009 April 18. 

Meng X, Martinez M, Raymond-Stintz M, Winter S, Wilson B.  IKK Inhibitor Bay 11-7082 Induces Necroptotic Cell Death in Precursor-B Acute Lymphoblastic Leukaemic Blasts.  Br J Haematol.  2009 February. 148(3):487-90.

Wilson B, Meng X, Mazel T, Willman C, Atlas A, Chen I, Harvey R, Hunger S, Oliver J, Winter S.  Select y-Secretase Inhibitors Induce Apoptosis in Pre-B ALL Cells and Disrupt the Balance Between Constitutive Notch Signaling and Repression (Poster).  50th ASH Annual Meeting and Exposition.  2008 December 6. 

Russell T, Oliver J, Wilson B, Tarleton C, Winter S, Meng X.  Differential Expression of Ikaros Isoforms in Monozygotic Twins with MLL-rearranged Precursor-B Acute Lymphoblastic Leukemia.  Journal of Pediatric Hematology/Oncology.  2008 December. 30(12):941-4.

Meng X, Fan J, Shen Z.  Roles of BCCIP in Chromosome Stability and Cytokinesis.  Oncogene.  2007 September. 26(43):6253-60.

Lu H, Yue J, Meng X, Nickoloff J, Shen Z.  BCCIP Regulates Homologous Recombination by Distinct Domains and Suppresses Spontaneous DNA Damage.  Nucleic Acid Res.  2007. 35(21):7160-70.

Meng X, Yue J, Liu Z, Shen Z.  Abrogation of the Transactivation Activity of p53 by BCCIP Down-Regulation.  The Journal of Biological Chemistry.  2007 January. 282(3):1570-6.

Lu H, Guo X, Meng X, Liu J, Allen C, Wray J, Nickoloff J, Shen Z.  The BRCA2-Interacting Protein BCCIP Functions in RAD51 and BRCA2 Focus Formation and Homologous Recombinational Repair.  Molecular and Cellular Biology.  2005 March. 25(5):1949-57.

Meng X, Lu H, Shen Z.  BCCIP Functions Through p53 to Regulate the Expression of p21Waf1/Cip1.  Cell Cycle (Georgetown, Tex.).  2004 November. 3(11):1457-62.

Meng X, Liu J, Shen Z.  Inhibition of G1 to S Cell Cycle Progression by BCCIPβ.  Cell Cycle (Georgetown, Tex.).  2004 March. 3(3):343-8.

Meng X, Yuan Y, Maestas A, Shen Z.  Recovery from DNA Damage-Induced G2 Arrest Requires Actin-Binding Protein Filamin-Actin-Binding Protein 280.  The Journal of Biological Chemistry.  2004 February. 279(7):6098-6105.

Meng X, Lu H, Shen Z.  Radiation-Induced G1/S Checkpoint Activation: Roles of BCCIP on p21 Expression and Intracellular Distribution (Poster).  Radiation Research Society 51st Annual Meeting, St. Louis, MO.  2004. 

Meng X, Lu H, Shen Z.  Radiation-Induced G1/S Checkpoint Activation: Roles of BRAC2 in BCCIP-Dependent Regulation of p21 Expression (Poster).  Radiation Biology and Cancer: From Molecular Responses to the Clinic, AACR Special Conference in Cancer Research, Dana Point, CA.  2004. 

Meng X, Liu J, Shen Z.  Genomic Structure of the Human BCCIP Gene and Its Expression in Cancer.  Gene.  2003 January. 302(2-Jan):139-46.

Liu J, Meng X, Shen Z.  Association of Human RAD52 Protein with Transcription Factors.  Biochemical and Biophysical Research Communications.  2002 October. 297(5):1191-6.

Meng X, Guo X, Liu J, Shen Z.  Functional Characterization of BCCIP, a BRCA2-Interacting Protein (Poster).  Era of Hope, The Department of Defense Breast Cancer Research Program Meeting.  2002. 

Meng X, Shen Z.  Interaction of BCCIP with PCNA and Transcription Factors (Talk).  Program & Abstracts of Radiation Research Society & North American Hyperthermia Society.  2002. 

Meng X, Dong Y, Sun Z.  ATM Plays a Role in DNA Damage Signal Transduction by Catalyzing Proteins Phosphorylation.  Chinese Science Bulletin.  1999. 44(19):1790-1794.

Meng X, Dong Y, Sun Z.  Gadd45 transcription activated by p53 take roles in DNA damage surveillance in diverse ways.  SCIENCE IN CHINA(Series C) .  1999. 42(4):428-434.

Meng X, Gong B, Mao J, Dong Y, Sun Z.  LD-PCR Amplification Full Length cDNA of ATM.  Bulletin of the Academy of Military Medical Sciences.  1999. 23(2):160.

Meng X, Sun Z.  Molecular Mechanism of Enhancement of Cellular Radiosensitivity by Wortmannin.  Chinese Journal of Biochemistry and Molecular Biology.  1999. 15(4):613-619.

Meng X, Dong Y, Sun Z.  p21, Gadd45 Transcription Activated by p53 Take Roles in DNA Damage Surveillance in Diverse Ways.  Science in China (Series C).  1999. 42(4):428-434.

Meng X, Sun Z.  Roles of p21 and Gadd45 in Human Cellular Spindle Checkpoint Regulation.  Bulletin of the Academy of Military Medical Sciences.  1999. 23(2):160-163.

Meng X, Mao J, Song Y, Sun Z.  The Role of ATM in DNA Damage Response to Ionizing Radiation (Poster).  International Symposium on Biology of Cancer Prevention and Treatment, China.  1999. 

Meng X, Sun Z.  Effects of Wortmannin and 3-AB on G2 Delay and MPF Transient Failure to Dephosphorylation Induced by Radiation.  Chinese Science Bulletin.  1998. 43(18):1550-1555.

Meng X, Ye C.  Multiple Roles of p21 in Cellular Proliferation Regulation.  Progress of Biochemistry and Biophysics.  1996. 23(3):224-228.

Meng X, Wei Q.  Endogenous Substrates of Calcineurin (CaN) in Mice Brains.  Chinese Science Bulletin.  1994. 39(12):1750-1754.

Meng X, Wei Q.  Proteins Phosphorylation and Dephosphorylation in Ischemia and Normal Mice Brains.  Chinese Journal of Biochemistry.  1994. 10(6):717-721.

Meng X, Wei Q.  Calmodulin Binding Proteins in Ischemia and Control Mice Brains.  Chinese Science Bulletin.  1993. 38(15):2083-2087.

Date Last Modified: 06/06/2016 - 13:17:48