Obstetrics and Gynecology

Mark K. Santillan, MD


Assistant Professor: Maternal Fetal Medicine
Course Director
Clinical Research Director
Assistant Fellowship Director
Assistant Professor of Obstetrics and Gynecology  - Maternal/Fetal Medicine

Contact Information

Primary Office: 31313 PFP
Iowa City, IA 52242

Phone: 319-353-7489

Email: mark-santillan@uiowa.edu


BA, Philosophy, Loyola University Chicago, Chicago, IL
BS, Chemistry with Biochemistry emphasis, Loyola University Chicago, Chicago, IL
MD, Doctor of Medicine, Loyola University Stritch School of Medicine, Maywood, IL

Residency, Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL
Fellowship, Maternal Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

Maternal Fetal Medicine Subspecialty Board Eligible, American Board of Obstetrics and Gynecology

Research Summary

Hypertensive Disorders in Pregnancy, Endothelial Dysfunction in Pregnancy, Immunology of, Pregnancy, Murine Models of Preeclampsia, Ultrasound

All Publications

Kempuraj D, Thangavel R, Fattal R, Pattani S, Yang E, Zaheer S, Santillan D, Santillan M, Zaheer A.  Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP+).  Neurochem Res .  2016 May. 41(5):1042-9.

Sandgren J, Santillan M, Grobe J.  Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions.  Hypertension.  2016 April 25. 

Muntner P, Becker R, Calhoun D, Chen D, Cowley Jr A, Flynn J, Grobe J, Kidambi S, Kotchen T, Lackland D, Leslie K, Li Y, Liang M, Lloyd A, Mattson D, Mendizabal B, Mitsnefes M, Nair A, Pierce G, Pollock J, Safford M, Santillan M, Sigmund C, Thomas S, Urbina  E.  Introduction to the American Heart Association's Hypertension Strategically Focused Research Network.  Hypertension .  2016 April. 67(4):674-80.

Sandgren J, Scroggins S, Santillan D, Devor E, Gibson-Corley K, Pierce G, Sigmund C, Santillan  M, Grobe  J.  Vasopressin: The Missing Link for Preeclampsia?.  Am J Physiol Regul Integr Comp Physiol.  2015 November 1. 309(9):R1062-4.

Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, Santillan M, Zaheer A.  Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.  PloS One.  2015 August 14. 10(8):e0135776.

Stegmann B, Santillan M, Leader B, Smith E, Santillan D.  Changes in antimullerian hormone levels in early pregnancy are associated with preterm birth.  Fertil Steril.  2015 August. 104(2):347-55.e3.

Adams  A, Hubb A, Santillan M, Nishimura T, Ruback R, Gravatt L, Higdon E, Schroeder K, Conklin J, Bender R, Hunter S, Santillan D.  Adherence to the updated guidelines for the prevention of perinatal Group B streptococcal disease.  Proc Obstet Gynecol.  2015 February. 4(3):[2 p].

Solheim K, Santillan D, Scroggins S, Devor E, Santillan M,  .  Global fetal DNA methylation and birth outcomes in obese women.  Proc Obstet Gynecol.  2015 February. 4(3):[2 p].

Santillan M, Pelham C, Ketsawatsomkron P, Santillan D, Davis D, Devor E, Gibson-Corley K, Scroggins S, Grobe J, Yang B, Hunter S, Sigmund C.  Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes.  Physiol Rep.  2015 January 19. 3(1):pii: e12257.

Li C, Railkwar N, Santillan M, Santillan D, Thomas C.  Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.  Placenta .  2015 January 17. 

Santillan M, Santillan D, Scroggins S, Sandgren J, Pearson N, Gibson-Corley K, Grobe  J.  Chronic vasopressin infusion throughout pregnancy phenocopies the physiologic, vascular, obstetric and immunologic phenotypes of human preeclampsia in mice .  Pregnancy Hypertens.  2015 January. 5(1).

Santillan M, Santillan D, Scroggins S, Min J, Leslie K, Hunter S, Zamba G, Gibson-Corley K, Grobe  J.  Vasopressin secretion in human pregnancy predicts the development of preeclampsia as early as the sixth week of gestation.  Pregnancy Hyprertens.  2015 January. 5(1):25-26.

Hansen J, Santillan M, Stegmann B, Foster T, Hardy-Fairbanks A,  .  Maternal demographic and clinical variables do not predict intrauterine contraception placement: Evidence for postplacental intrauterine contraception placement..  Proc Obstet Gynecol.  2014 October 30. 4(2):[7 p].

Santillan  M, Leslie  K, Hamilton  W, Boese B, Ahuja M, Hunter S, Santillan D.  Collection of a lifetime: a practical approach to developing a longitudinal collection of women's healthcare biological samples.  Eur J Obstet Gynecol Reprod Biol.  2014 August. 179:94-9.

Santillan M, Santillan D, Scroggins S, Min J, Sandgren J, Pearson  N, Leslie K, Hunter S, Zamba G, Gibson-Corley  K, Grobe J.  Vasopressin in Preeclampsia: A Novel Very Early Human Pregnancy Biomarker and Clinically Relevant Mouse Model .  Hypertension .  2014 July 7. 

Devor E, Reyes H, Santillan D, Santillan M, Onukwugha C, Goodheart M, Leslie  K.  Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions.  Obstet Gynecol Int.  2014 March 17. 2014:5 pages.

Kyser K, Lu X, Santillan D, Santillan M, Caughey A, Wilson M, Cram P,  .  Forceps Delivery Volumes in Teaching and Non-Teaching Hospitals: Are Volumes Sufficient for Acquisition and Maintenance of Competence?.  Academic Medicine .  2014 January. 1(89):71-6.

Santillan  M.  Wandering womb, water and worms: the history, myths, and messy immunologic etiology of preeclampsia/eclampsia .  Proc Obstet Gynecol.  2013 December 31. 3(3).

Kowalski J, Santillan D, Netz R, Sinkey C, Fleener D, Hunter S, Santillan M.  Flow mediated vasodilation predicts the development of gestational diabetes mellitus.  Proc Obstet Gynecol.  2013 December. 3(3):[2 p].

Taylor J, Conklin J, Hunter S, Empey R, Tyler E, Christensen A, Talcott A, Ballas Z, Santillan D,  M.  Defining normal IgG changes throughout pregnancy.  Proc Obstet Gynecol.  2013 July. 3(2):2.

Snyder M, Simmons L, Kitzman J, Santillan D, Santillan M, Gammill H, Shendure J.  Noninvasive fetal genome sequencing: a primer..  Prenatal diagnosis.  2013 June. 33(6):547-54.

Devor E, Santillan D, Santillan M.  Preeclampsia and MicroRNAs.  Proceedings in Obstetrics and Gynecology.  2013 March 27. 3(1):2.

Santillan D, Hamilton W, Christenson A, Talcott K, Gravatt L, Santillan M, Hunter S.  The effects of preeclampsia on signaling to hematopoietic progenitor cells.  Proceedings in Obstetrics and Gynecology.  2013 March. 3(1):3.

Kyser K, Lu X, Santillan D, Santillan M, Hunter S, Cahill A, Cram P.  The Association Between Hospital Obstetrical Volume and Maternal Postpartum Complications.  Am J Obstet Gynecol.  2012 July. 204:42.e1-17.

Santillan M, Santillan D, Fleener D, Stegmann B, Zamba G, Hunter S, Yankowitz J.  Single Umbilical Artery: Does Side Matter?.  Fetal Diagn Ther.  2012 June 20. 

Stegmann B, Santillan M, Santillan D, Smith E, Van Voorhis B, Schultz K.  Anti-Mullerian Hormone concentration levels in maternal plasma during the first, second and third trimester of pregnancy.  Proc Obstet Gynecol.  2012 May. 2(3):Article 2 [2p.].

Empey R, Santillan D, Santillan M, Tyler E, Hunter S, Smith E, Stegmann B.  The influence of fetal sex on patterns of change in anti-Mullerian hormone during pregnancy..  Proc Obstet Gynecol.  2012 May. 2(3):Article 4 [2 p.].

Santillan M, Raghuraman N, Naruko-Stewart K, Cooper K, Santillan D, Zamba G, Greiner A.  Diuresis: Physiologic Cues to Decrease Postpartum Magnesium Administration.  In Preparation .  2012. 

Tabor H, Murray J, Gammill H, Kitzman J, Snyder M, Ventura M, Lewis A, Qiu R, Simmons L, Rubens C, Santillan M, Eichler E, Cheng E, Bamshad M, Shendure J.  Non-invasive Fetal Genome Sequencing: Opportunities and Challenges.  Am J Med Genet Part A.  2012. 9999(1):3.

Santillan D, Rai K, Santillan M, Krishnamachari Y, Salem A, Hunter S.  Efficacy of Polymeric Encapsulated C5a peptidase-based Group B Streptococci Vaccines in a Murine Model.  Am J Obstet Gynecol.  2011 September. 205(3):249.e1-8.

Stegmann B, Santillan D, Santillan M, Van Voorhis B, Smith E.  Hormone Changes in Pregnancy and Prediction of Adverse Pregnancy Outcomes.  Reproductive Sciences.  2011 March. 18(3, Supplement):1A-68A.

Rai K, Santillan D, Santillan M, Hamilton W, Krishnamachari Y, Salem A, Hunter S.  Prevention of Group B Streptococcus (GBS) colonization by multiple GBS serotypes using a novel GBS vaccine..  American Journal of Obstetrics & Gynecology.  2011 January. 204(1, Supplement):S22-S23.

Santillan D, Santillan M, Rai K, Hunter S.  Treatment of maternal PKU: Safety and Efficacy of a Novel Engineered Metabolic System.  American Journal of Obstetrics & Gynecology.  2011 January. 204(1, Supplement):S322-S323.

Santillan M, Santillan D.  2010 Updates of the CDC Guidelines for GBS in pregnancy..  The Perinatal Letter.  2010 4th Quarter. XXXI(4).

Santillan M, Yankowitz J,  .  Fetal effects of drugs commonly used in critical care.  Wiley-Blackwell.  2010 October. 

Santillan M, Yankowitz J.  Fetal effects of drugs commonly used in critical care..  Wiley-Blackwell.  2010 October. 

Santillan M, Pelham C, Ketsawatsomkron P, Santillan D, Yang B, Hunter S, Sigmund C.  Indoleamine 2,3 Dioxygenase (IDO) Deficiency Results in Vascular Dysfunction and Proteinuria in Pregnancy.  Hypertension.  2010. 56(e91):174.

Santillan M, Santillan D, Sigmund C, Hunter S.  IDO and sFLT-1: A Potential Molecular Link Between the Immune System and Preeclampsia.  Am J Obstet Gynecol.  2009 December. 199(6):S83.

Santillan D, Santillan M, Hunter S.  Cell Encapsulation Technology as a Useful Non-Dietary Therapy for Maternal Phenylketonuria.  Am J Obstet Gynecol.  2009 September. 201(3):289.E1-6.

Santillan M, Santillan D, Sigmund C, Hunter S.  From molecules to medicine: A future cure for preeclampsia?.  Drug News Perspect.  2009 September. 22(9):531-541.

Santillan M, Hunter S.  Preeclampsia/Eclampsia: An Immediate and Long Term Problem.  The Perinatal Letter.  2008 December. 29(4):16.

Santillan M, Herring J, Hoppensteadt D, Jeske W, Herbert J, Fareed J.  The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys..  Clin Appl Thromb Hemost.  2001 January. 7(1):10-5.

Santillan M, Ero M, Hoppnesteadt D, Jeske W, Herbert J, Fareed J.  Pharmacokinetics and pharmacodynamics of a novel glycoprotein IIb/IIIa antagonist, SR 121566A.  Blood.  1997 December. 

Santillan M, Santillan D, Gianopoulos J, Mestril R, Koh M.  A Potential Role for Heat Shock Protein 60 (HSP60) in Preeclampsia. In Preparation.. 

Santillan M, Cox L, Shchelochkov O.  Another Mimicker of Severe Preeclampsia: Lysinuric Protein Intolerance in Pregnancy. In Preparation.. 

Santillan M, Pelham C, Ketasawatsomkron P, Santillan D, Yang B, Hunter S, Sigmund C.  Chronic Indoleamine 2,3 Dioxygenase (IDO) Deficiency: A Novel Immunologic Model of Preeclampsia. In Preparation.. 

Santillan M, Leslie K, Hamilton W, Boese B, Conklin J, Empey R, Tyler E, Talcott K, Christensen A, Abel J, Ahuja M, Sanbory A, Sweezer E, Hunter S, Santillan D.  Collection of a Lifetime: Development of a Longitudinal Collection of Women's Healthcare Biological Samples.  Submitted to Am J Obstet Gynecol. 

Santillan M, Kowalski J, Santillan D, Fleener D, Netz R, Hunter S, Haynes W.  Determinants of Changes in Flow Mediated Dilation and Pulse Wave Analysis Throughout All Trimesters of Normal Pregnancies. In Preparation.. 

Eppsteiner E, Santillan M, Stegmann B,  .  Influence of Infertility Diagnosis on Pregnancy Outcome in ART.  POG.  Article 1:10.

Santillan M.  Pharmacodynamics of a novel GPIIb/IIIa antagonist prodrug: In vivo and In vitro studies.. 

Santillan M, Ramachandram S, Santillan D, Hunter S, Leslie K, Devor E,  .  Setting the Tone: Human Placenta microRNA expression is Established in Gestation.  Submitted to Am J Obstet Gynecol. 

Kempuraj D, Ramasamy T, Zaheer S, Santillan D, Santillan M, Zaheer A.  The Parkinsonian toxin 1 – methyl -4 – phenylpyridinium (MPP+), and proteins α-synuclein and glia maturation factor (GMF) activate mast cells and release proinflammatory mediators.  MDS 19th International Congress of Parkinson's Disease and Movement Disorders.  30.

Date Last Modified: 06/06/2016 - 13:17:48