Research Assistant Professor of Obstetrics and Gynecology
- Reproductive Science Research
Primary Office: 463A MRF
Iowa City, IA 52242
BS, University of New Mexico, Albuquerque, New Mexico
MS, Anthropology, University of New Mexico, Albuquerque, New Mexico
PhD, University of New Mexico, Albuquerque, New Mexico
Post Doctorate, Quantitative/Population Genetics, Washington University School of Medicine, St. Louis, Missouri
Research is focused on the role of the protein Placenta-specific Protein 1 (PLAC1) in both normal and pathologic phenomena spanning the range of Obstetrics and Gynecology from the development and maintenance of a healthy placenta to preeclampsia to gynecologic cancers. PLAC1 is normally expressed only in the placenta. Current projects have shown 1) that the PLAC1gene emerged in the genome of the earliest placental mammals 165 million years ago and has remained essentially unchanged since, 2) that PLAC1 expression is significantly lower in the placentas of women who develop preeclampsia than in the placentas of women who do not and that this difference is influenced by a hypoxia-mediated mechanism, 3) that PLAC1 is turned on in gynecologic cancers, is an indicator of poor outcomes and is significantly influenced by p53 mutation status.
Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182..
2016 April. 35(4):2461-2465.
Placenta-specific protein 1 is conserved throughout the Placentalia under purifying selection.
The Scientific World Journal.
2014 August 7. 2014:Article ID 537356, 5 pages.
microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families.
2014 May. 2(3):387-387.
Placenta-specific protein 1: a potential key to many oncofetal-placental OB/GYN research questions.
Obstet Gynecol Int..
2014 March 17. 2014:5 pages.
Van Voorhis B.
MicroRNA expression in the human blastocyst..
2013 March 1. 99(3):855-61.
The onco-placental gene placenta-specific protein 1 (PLAC1) is highly expressed in endometrial tumors and cell lines.
Obstetrics and Gynecology International.
Global dysregulation of the chromosome 14q32 imprinted region in uterine carcinosarcoma..
Experimental and Therapeutic Medicine.
2012 April. 3(4):677-682.
MicroRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique, and differentiating groups of microRNAs.
Oncology Reports .
2011 October. 26(4):995-1002.
Towards a microRNA signature of endometrial cancer.
Proc Obstet Gynecol .
2011. 2:Article 7.
MicroRNAs, cellular behavior, and endometrial cancer.
Proc Obstet Gynecol.
2010. 1:Article 1.
Date Last Modified: 06/06/2016 -