Obstetrics and Gynecology

Donghai Dai, MD, PhD


Research Associate Professor of Obstetrics and Gynecology  - Reproductive Science Research

Contact Information

Primary Office: 3234 MERF
Iowa City, IA 52242
Phone: 319-384-1127

Email: donghai-dai@uiowa.edu


MD, Medicine, Shanghai Medical University
PhD, Endocrinology, Medical College of Georgia
MS, Bioinformatics, University of Iowa

Residency, Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, P.R. China
Residency, Chief Resident, Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, P.R. China
Post Doctorate, Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Post Doctorate, Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado

All Publications

Salinas E, Dai D, Newtson A, McDonald M, Goodheart M, Leslie K, Gonzalez Bosquet J.  Pre-treatment Prediction Model in Endometrioid Andeocarcinoma of the Uterus Using Somatic Mutations.  Gynecol Onc.  2016 October. 143(1):215.

Salinas E, Dai D, Newtson A, Leslie K, Gonzalez Bosquet J.  Prediction Model for Presurgical Risk Assessment in Endometrial Cancer.  Gynecol Onc.  2016 October. 143(1):207-208.

Dai D, Thiel K, Salinas E, Goodheart M, Leslie K, Gonzalez Bosquet J.  Stratification of endometrioid endometrial cancer patients into risk levels using somatic mutations.  Gynecol Oncol.  2016 July. 142(1):150-7.

Reyes H, Carlson M, Devor E, Zhang Y, Thiel K, Samuelson M, McDonald M, Yang S, Stephan J, Savage E, Dai D, Goodheart M, Leslie K.  Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices.  Gynecol Oncol.  2016 January. 140(1):152-60.

Hovey A, Devor E, Breheny P, Mott S, Dai D, Thiel K, Leslie K.  miR-888: A Novel Cancer-Testis Antigen that Targets the Progesterone Receptor in Endometrial Cancer.  Translational Oncology.  2015 April. 8(2):85-96.

Brachova P, Mueting S, Carlson M, Goodheart M, Button A, Mott S, Dai D, Thiel K, Devor E, Leslie K.  Tp53 Oncomorphic Mutations Predict Resistance to Platinum and Taxanebased Standard Chemotherapy in Patients Diagnosed with Advanced Serous Ovarian Carcinoma.  Int J Oncol.  2015 February. 46(2):607-18.

Yang S, Jia Y, Liu X, Winters C, Wang X, Zhang Y, Devor E, Hovey A, Reyes H, Xiao X, Xu Y, Dai D, Meng X, Thiel K, Domann F, Leslie K.  Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer [Epub ahead of print].  Oncotarget.  2014 October 30. 5(20):9783-97.

Petrie W, Dennis M, Hu C, Dai D, Arterburn J, Smith H, Hathaway H, Prossnitz E.  G Protein-coupled Estrogen Receptor-selective Ligands Modulate Endometrial Tumor Growth.  Obstet Gynecol Int.  2013 November 27. 

Leslie K, Thiel K, Reyes H, Yang S, Zhang Y, Carlson M, Kumar N, Dai D.  The Estrogen Receptor Joins other Cancer Biomarkers as a Predictor of Outcome.  Obstet Gynecol Int.  2013 October 7. 

Meng X, Laidler L, Kosmacek E, Yang S, Xiong Z, Zhu D, Wang X, Dai D, Zhang Y, Wang X, Brachova P, Albitar L, Liu D, Ianzini F, Mackey M, Leslie K.  Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53..  Gynecologic oncology.  2013 March. 128(3):461-9.

Howk C, Voller Z, Beck B, Dai D.  Genetic Diversity in Normal Cell Populations is the Earliest Stage of Oncogenesis Leading to Intra-Tumor Heterogeneity..  Frontiers in oncology.  2013. 3:61.

Zhang G, Beck B, Luo W, Wu F, Kingsmore S, Dai D.  Development of a phylogenetic tree model to investigate the role of genetic mutations in endometrial tumors.  Oncology Reports.  2011. 25:1447.

Davies S, Dai D, Pickett G, Thiel K, Korovkina  V, Leslie K.  Effects of bevacizumab in mouse model of endometrial cancer: defining the molecular basis for resistance.  Oncology Reports.  2011. 3:855.

Dai D, Beck B, Wang X, Howk C, Li Y.  Quantitative interpretation of a genetic model of carcinogenesis using computer simulations.  PLoS One.  2011. 6:e16859.

Dai D, Beck B, Zhang G, Luo W, Wu F, Kingsmore S.  Development of a phylogenetic tree model to investigate the role of individual mutations in a single patient tumor.  2010 April. 

Luo W, Wu F, Elmaoued R, Beck B, Fischer E, Meng X, Leslie K, Dai D.  Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent.  Int J Oncology .  2010. 37:1187.

Luo W, Wu F, Atlas S, Pickett G, Leslie K, Dai D.  Defining genetic intra-tumor heterogeneity: a chronological annotation of mutational pathways.  Proc Obstet Gynecol.  2010. 1:9-23.

Beck B, Wang X, Howk C, Luo W, Dai D.  Development of a contra-indicatory biomarker to predict drug resistance and treatment failure.  2010. 

Dai D, Luo W, Wu F, Atlas S.  Defining intra-tumor mutational pathways through chronological annotation.  2008 April. 

Atlas S, Luo W, Wu F, Fischer E, Dai D.  Phylogenetic analysis of tumors.  2008 April. 

Arias-Pulido  H, Joste N, Chavez A, Muller C, Dai D, Smith H, Verschraegen .  Absence of epidermal growth factor receptor mutations in cervical cancer.  Int J Gynecol Cancer .  2008. 18:749-757.

Nayak T, Hathaway H, Ramesh C, Arterburn J, Dai D, Sklar L, Norenberg J, Prossnitz E.  Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.  J Nucl Med .  2008. 49:978-986S.

Cole L, Dai D, Butler S, Leslie K, Kohorn E.  Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG..  Gynecol Onc.  2006 August. 102(2):145-50.

Davies S, Dai D, Pickett G, Leslie K.  Gene regulation profiles by progesterone and dexamethasone in human endometrial cancer Ishikawa H cells.  Gynecol Oncol .  2006 April. 101:62-70.

Laidler L, Dai D, Leslie K.  Effects of Iressa on endometrial cancer cell lines.  2005 March. 

Davies S, Dai D, Pickett G, Leslie K.  Genomic analysis identifies PRA/PRB as the most transcriptionally active progesterone receptor dimer in human poorly-differentiated Hec50co endometrial cancer cells.  The 52nd Annual Meeting of Society for Gynecologic Investigation.  2005 March. 

Davies S, Dai D, Pickett G, Leslie K.  Overlapping but distinct gene regulation profiles by progesterone and dexamethasone in human endometrial cancer ishikawah cells.  2005 March. 

Dai D, Holmes A, Nguyen T, Davies S, Leslie K.  Synergistic anti-cancer effects of paclitaxel and amifostine in endometrial cancer.  2005 March. 

Davies S, Dai D, Pickett G, Leslie K.  Differential gene regulation by the two progesterone receptor isoforms in human poorly-differentiated Hec50co endometrial cancer cells.  2005 February. 

Laidler L, Dai D, Leslie K.  Effects of Iressa on endometrial cancer cell lines.  2005 February. 

Dai D, Albitar L, Nguyen T, Laidler  L, Singh M, Leslie K.  Inhibition of endometrial cancer growth through re-institution of progesterone signaling.  2005 February. 

Dai D, Holmes A, Nguyen T.  A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer.  Cancer Res.  2005. 65(20):9517.

Leslie K, Stein M, Kumar N, Dai D, Stephens J, Wandinger-Ness  A, Glueck D.  Progesterone receptor isoform identification and subcellular localization in endometrial cancer.  Gynecol Oncol.  2005. 96:32.

Leslie K, Laidler L, Albitar L, Davies S, Holmes A, Nguyen T, Bolnick J, Dai D.  Tyrosine kinase inhibitors in endometrial cancer.  Int J Gynecol Cancer .  2005. 15:398.

Dai D, Albitar L, Nguyen T, Laidler L, Singh M, Leslie K.  A therapeutic model for advanced endometrial cancer: systemic progestin in combination with local adenoviral mediated progesterone receptor expression.  Mol Cancer Ther.  2005 January. 4:169.

Davies S, Dai D, Wolf D, Leslie K.  Immunomodulatory and transcriptional effects of progesterone through progesterone A and B receptors in Hec50co poorly differentiated endometrial cancer cells..  Journal of the Society for Gynecologic Investigation.  2004 October. 11(7):494-9.

Davies S, Dai D, Feldman  I, Pickett G, Leslie K.  Identification of a novel mechanism of NF-kB inactivation by progesterone through progesterone receptors in Hec50co poorly differentiated endometrial cancer cells: induction of A20 and ABIN-2.  Gynecol Oncol.  2004. 94:463.

Davies S, Dai D, Velazquez M, Laidler L, Wolf D, Leslie K.  Genomic and non-genomic anti-inflammatory effects of progesterone on endometrial cancer cells.  2003 March. 

Dai D, Laidler L, Nguyen T, Al-Bitar L, Leslie K.  A Therapeutic Mouse Model for the Treatment of Advanced Endometrial Cancer.  2003 February. 

Dai D, Litman E, Schonteich E, Leslie K.  Progesterone regulation of AP-1 transcriptional activity: a mechanism of progesterone inhibition of endometrial cancer cell growth.  J Steroid Biochem Mol Biol.  2003. 87:123.

Dai D, Leslie K.  Progesterone regulation of AP-1 transcriptional activity: a mechanism underlying the inhibition of endometrial cancer cell growth.  2002 June. 

Leslie K, Dai D.  Effects of estrogen and progesterone on the female reproductive tract.  2002 April. 

Dai D, Leslie K.  Progesterone inhibits endometrial cancer cell growth through regulation of AP-1 transcriptional factors.  2002 April. 

Dai D, Wolf D, Litman E, White M, Leslie K.  Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors.  Cancer Res.  2002. 62:881.

Dai D, Kumar N, Wolf D, Leslie K.  Molecular tools to re-establish progestin control of endometrial cancer cell proliferation.  Am J Obstet Gynecol.  2001. 184:790.

Dai D, Ogle T.  Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl-2 family members.  Biol Reprod .  2000. 63:188.

Ogle T, Dai D, George P.  Progesterone regulated determinants of stromal cell survival and death in uterine decidua are linked to protein kinase C activity.  Steroids.  1999. 64:628.

Dai D, Ogle T.  Progesterone regulation of epidermal growth factor receptor in rat decidua basalis during pregnancy.  Biol Reprod.  1999. 61:326.

Sohal G, Ali M, Ali A, Dai D.  Ventrally emigrating neural tube cells contribute to the formation of Meckel's and quadrate cartilage.  Dev Dyn.  1999. 216:3.

Sohal G, Ali M, Ali A, Dai D.  Ventrally emigrating neural tube cells differentiate into heart muscle: Biochem.  Biophys Res Commun.  1999. 254:601.

Ali A, Ali M, Dai D, Sohal G.  Ventrally emigrating neural tube cells differentiate into vascular smooth muscle cells.  Gen Pharmacol.  1999. 33:401.

Ogle T, Dai D, George P.  Progesterone and estrogen regulation of decidual cell expression of proliferating cell nuclear antigen.  Biol Reprod.  1998. 59:444-50.

Ogle T, Dai D, George P, Mahesh V.  Regulation of the progesterone and estrogen receptors in decidua basalis by progesterone and estradiol during pregnancy.  Biol Reprod.  1998. 58:1188-98.

Ogle T, Dai D, George P, Mahesh V.  Stromal cell progesterone and estrogen receptors during proliferation and regression of the decidua basalis in the pregnant rat.  Biol Reprod.  1997. 57:496-506.

Date Last Modified: 06/06/2016 - 13:17:48