Asgar Zaheer, PhD


Specialty: Neurobiology
Emeritus Associate Professor of Neurology

Contact Information

Primary Office: 431 MRC
Iowa City, IA 52242
Phone: 319-353-6094



PhD, Biochemistry, Bombay University, India

Post Doctorate, Biochemistry, University of Iowa

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

My laboratory has a long-term commitment to study the properties and functions of Glia Maturation Factor, a brain specific protein that we discovered in our laboratory at the Department of Neurology, the University of Iowa. My research group uses interdisciplinary approaches to understand the function of GMF and the regulation of inflammatory signaling pathways relevant to neurodegenerative diseases. I have an NIH RO1 funded program on GMF-depended neuro inflammation and neuro degeneration, an NIH RO1 funded program on GMF in CNS Inflammation and a VA Merit Review Award funded program on the role of GMF in Dementia. Our work embraces neuroimmunology, neuropathology, molecular biology, and neurochemistry. The lab is highly collaborative and multidisciplinary, offering a rich training environment in neuroscience. My laboratory has many years experience in using immunocytochemical techniques to examine tissue samples using both light and epifluorescence microscopy. I will provide any training and guidance to the best of my ability.

Selected Publications

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Kempuraj D, Khan M, Thangavel R, Xiong Z, Yang E, Zaheer A.  Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases..  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.  2013 February. 

Khan M, Kempuraj D, Thangavel R, Zaheer A.  Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol..  Neurochemistry international.  2013 February. 62(4):379-388.

Zaheer S, Thangavel R, Wu Y, Khan M, Kempuraj D, Zaheer A.  Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice..  Neurochemical research.  2013 January. 38(1):218-25.

Thangavel R, Stolmeier D, Yang X, Anantharam P, Zaheer A.  Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease..  Neuropathology and applied neurobiology.  2012 October. 38(6):572-81.

Zaheer S, Wu Y, Yang X, Thangavel R, Sahu S, Zaheer A.  Efficient down-regulation of glia maturation factor expression in mouse brain and spinal cord..  Neurochemical research.  2012 July. 37(7):1578-83.

Zaheer S, Wu Y, Yang X, Ahrens M, Sahu S, Zaheer A.  Clinical course of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor..  Neurochemistry international.  2012 February. 60(3):215-9.

Zaheer S, Thangavel R, Sahu S, Zaheer A.  Augmented expression of glia maturation factor in Alzheimer's disease..  Neuroscience.  2011 October. 194:227-33.

Zaheer S, Wu Y, Sahu S, Zaheer A.  Suppression of neuro inflammation in experimental autoimmune encephalomyelitis by glia maturation factor antibody..  Brain research.  2011 February. 1373:230-9.

Zaheer S, Wu Y, Sahu S, Zaheer A.  Overexpression of glia maturation factor reinstates susceptibility to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in glia maturation factor deficient mice..  Neurobiology of disease.  2010 December. 40(3):593-8.

Samuel I, Yorek M, Zaheer A, Fisher R.  Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis..  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.  10(7):950-9.

Date Last Modified: 08/02/2016 - 15:30:33