Neurology

Andrew Russo, PhD

Portrait

Research Health Science Specialist, Director of Animal Research
Professor of Molecular Physiology and Biophysics
Professor of Neurology

Contact Information

Primary Office: 5-432 BSB
51 Newton Road
Iowa City, IA 52242
Phone: 319-335-7872

Email: andrew-russo@uiowa.edu
Web: Russo Laboratory

Education

BA, Biology (concentrations in biochemistry and microbiology), University of California
PhD, Biochemistry, University of California

Post Doctorate, Molecular Neurobiology, Department of Medicine, UCSD

Education/Training Program Affiliations

Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

My research interest is to understand how neurons respond to changes in their environment. We have focused on regulation of CGRP and its actions in the context of trigeminal-mediated disorders, especially migraine. A recent focus of the lab is a CGRP-sensitized transgenic mouse model we generated based on clinical reports that injection of CGRP is able to induce a migraine, but not in people who do not suffer from migraine. These sensitized mice overexpress the RAMP1 subunit of the CGRP receptor in the nervous system. The RAMP1 mice have elevated CGRP-induced neurogenic inflammation, mechanical allodynia, and light aversion analogous to photophobia. In collaborative projects, the lab is also studying the beneficial effects of CGRP and RAMP1 against hypertension and obesity, with overall goals to develop effective diagnostic and therapeutic strategies for neurovascular disorders.

All Publications

Russo A.  CGRP as a neuropeptide in migraine: lessons from mice..  British journal of clinical pharmacology.  2015 September 1. 80(3):403-14.
[PubMed]

Walker C, Eftekhari S, Bower R, Wilderman A, Insel P, Edvinsson L, Waldvogel H, Jamaluddin M, Russo A, Hay D.  A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.  Ann Clin Transl Neurol.  2015 June. 2(6):595-608.
[PubMed]

Russo A.  Calcitonin gene-related peptide (CGRP): a new target for migraine..  Annual review of pharmacology and toxicology.  2015 January 1. 55:533-52.
[PubMed]

Russo A.  Migraine meets membrane trafficking..  Cephalalgia : an international journal of headache.  2014 October 1. 34(11):851-2.
[PubMed]

Kuburas A, Thompson S, Artemyev N, Kardon R, Russo A.  Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsia..  Investigative ophthalmology & visual science.  2014 September 25. 55(10):6878-85.
[PubMed]

Charles A, Pain Research Forum , Russo A, Shapiro R, Dussor G.  Paradigm Shifts in Migraine Science: New Opportunities for Therapy and Implications for Other Pain Disorders.  Pain Research Forum [painresearchforum.org].  2014 April 17. 
[Link]

Raddant A, Russo A.  Reactive oxygen species induce procalcitonin expression in trigeminal ganglia glia..  Headache.  2014 March 1. 54(3):472-84.
[PubMed]

White S, Marquez de Prado B, Russo A, Hammond D.  Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis 1.  PLOS ONE.  2014. 9(e106767).

White S, de Marquez Prado B, Russo A, Hammond D.  Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis..  PloS one.  2014 January 1. 9(9):e106767.
[PubMed]

Kaiser E, Russo A.  CGRP and migraine: could PACAP play a role too?.  Neuropeptides.  2013 December 1. 47(6):451-61.
[PubMed]

Russo A, Recober A.  Unanswered questions in headache: so what is photophobia, anyway?.  Headache.  2013 November 1. 53(10):1677-8.
[PubMed]

Fernandes-Santos C, Zhang Z, Morgan D, Guo D, Russo A, Rahmouni K.  Amylin acts in the central nervous system to increase sympathetic nerve activity..  Endocrinology.  2013 July 1. 154(7):2481-8.
[PubMed]

Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li  X, Gao S, Engle J, Kuburas A, Fu X, Yu W, Klein W, Russo A, Amendt B.  Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity..  The Journal of biological chemistry.  2013 May 3. 288(18):12580-95.
[PubMed]

Mason B, Kaiser E, Kuburas A, Rea B, Russo A.  CGRP sites of action in light aversive behavior.  Society for Neuroscience annual meeting, San Diego, CA.  2013. 

Kaiser E, Kuburas A, Rea B, Poolman P, Tye A, Recober A, Kardon R, Russo A.  Exploring the mechanisms involved in CGRP-induced light aversion in mice.  International Headache Congress, Philadelphia, PA.  2013. 

Kuburas A, Thompson S, Artemyev N, Kardon R, Russo A.  Light aversive behavior in mice lacking Rgs9.  Society for Neuroscience annual meeting, San Diego, CA.  2013. 

Rea B, Kaiser E, Poolman P, Thompson S, Recober A, Kardon R, Russo A.  The role of CGRP and hotic blink response in central trigeminal hypersensitivity and photophobia in migraine.  Society for Neuroscience annual meeting, San Diego, CA.  2013. 

Kaiser E, Kuburas A, Recober A, Russo A.  Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B/D) agonist..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2012 October 31. 32(44):15439-49.
[PubMed]

Raddant A, Russo A.  Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation..  Expert reviews in molecular medicine.  2011 November 29. 13:e36.
[PubMed]

Xie W, Fisher J, Lynch T, Luo M, Evans T, Neff T, Zhou W, Zhang Y, Ou Y, Bunnett N, Russo A, Goodheart M, Parekh K, Liu X, Engelhardt J.  CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice..  The Journal of clinical investigation.  2011 August 1. 121(8):3144-58.
[PubMed]

Russo A, Ferrari M, VanDenBrink  A.  Scholarship Review.  2011 June. 51(6):1047-1048.

Park K, Fletcher J, Raddant A, Russo A.  Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glia..  Cephalalgia : an international journal of headache.  2011 April 1. 31(5):614-24.
[PubMed]

Zhang Z, Liu X, Morgan D, Kuburas A, Thedens D, Russo A, Rahmouni K.  Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice..  Diabetes.  2011 April 1. 60(4):1063-71.
[PubMed]

Raddant A, Russo A.  CGRP in migraine: Intersection of peripheral inflammation and central modulation.  2011. 13(36).
[PubMed]

Kaiser E, Kuburas A, Recober A, Russo A.  CGRP-Induced Light Aversion in Preclinical Models of Migraine.  6th Annual Symposium on Advances in Pain Research, NIH Pain Consortium, Bethesda, Maryland.  2011. 

Kaiser E, Kuburas A, Recober A, Russo A.  CGRP-Induced Photophobia-like Behavior in Preclinical Models of Migraine.  Headache (53rd Annual Scientific Meeting, American Headache Society 2011, Washington DC).  2011. 

Russo A, Regan  J, VanPutte  C.  Seeley’s Anatomy and Physiology.  9. New York, NY;  2011.

Sabharwal R, Abboud F, Russo A, Chapleau M.  Transgenic expression of CGRP receptor subunit RAMP1 in nervous system improves autonomic regulation and prevents angiotensin II hypertension.  FASEB J.  2011. 

Thompson S, Recober A, Vogel T, Kuburas A, Owens J, Sheffield V, Russo A, Stone E.  Light aversion in mice depends on nonimage-forming irradiance detection..  Behavioral neuroscience.  2010 December 1. 124(6):821-7.
[PubMed]

Chrissobolis S, Zhang Z, Kinzenbaw D, Lynch C, Russo A, Faraci F.  Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction..  Stroke; a journal of cerebral circulation.  2010 October 1. 41(10):2329-34.
[PubMed]

Sabharwal R, Zhang Z, Lu Y, Abboud F, Russo A, Chapleau M.  Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension..  Hypertension (Dallas, Tex. : 1979).  2010 March 1. 55(3):627-35.
[PubMed]

Raddant A, Kuburas A, Recober A, Russo A.  A physiological trigger of light aversion in a mouse model of migraine.  Soc Neurosci Abstracts.  2010. 

Peotta V, Weiss R, Zimmerman K, Lu Y, Russo A, Abboud F, Chapleau M.  Consequences of enhanced CGRP receptor signaling on cardiac function and mortality post-myocardial infarction.  FASEB J.  2010. 24(1037):4.

Raddant A, Park K, Fletcher J, Russo A.  Epigenetic regulation of CALCA gene expression in trigeminal glia.  7th International Symposia on the CGRP Family: CGRP, Adrenomedullin, Amylin, Intermedin and Calcitonin.  2010. 

Fletcher J, Park K, Zhang Z, Russo A.  Epigenetic regulation of the CALCA gene.  Soc Neurosci Abstracts .  2010. 

Kaiser E, Kuburas A, Recober A, Marquez de Prado  B, Russo A.  Factors influencing light aversion in a migraine mouse model.  Soc Neurosci Abstracts.  2010. 

Russo A, Park  K.  Genetic regulation of CGRP and its actions.  Springer.  2010. 

Kaiser E, Russo A.  Photophobia-like behavior in a preclinical model.  Am Headache Soc annual meeting.  2010. 

Wang J, Zhang Z, Saadi I, Fu X, Engel J, Kuburas A, Russo A, Amendt B.  PIAS1 and PIASy Regulate PITX2 Activity During Tooth Development.  Int Assoc Dental Res 89th General Session Proceedings #147492.  2010. 

Russo A, Schwedt T, Goadsby P.  Scholarship Review.  2010. 50:520-526 .
[PubMed]

Recober A, Kaiser E, Kuburas A, Russo A.  Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP..  Neuropharmacology.  2010 January 1. 58(1):156-65.
[PubMed]

de Marquez Prado B, Hammond D, Russo A.  Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice..  The journal of pain : official journal of the American Pain Society.  2009 September 1. 10(9):992-1000.
[PubMed]

Russo A.  Scholarship Review.  2009 August. 
[Link]

Recober A, Kuburas A, Zhang Z, Wemmie J, Anderson M, Russo A.  Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2009 July 8. 29(27):8798-804.
[PubMed]

Russo A, Recober  A.  Calcitonin gene-related peptide: an update on the biology.  2009. 22:241-246 .
[PubMed]

Recober A, Kaiser E, Kuburas A, Wemmie J, Anderson M, Russo A.  CGRP-induced photophobia blocked by olcegepant and rizatriptan in a transgenic migraine model.  14th International Headache Congress.  2009. 

Russo A.  Commentary in News & Analysis, Biobusiness Briefs, Trial Watch. CGRP receptor antagonist meets Phase III migraine end points.  2009. 8(836).

Chrissobolis S, Zhang Z, Kinzenbaw D, Russo A, Faraci F.  Evidence for a Protective Role for Receptor Activity Modifying Protein-1 (RAMP1) in Angiotensin II-Induced Endothelial Dysfunction.  FASEB Journal.  2009. 23(1017):24.

Raddant A, Recober A, Zhang Z, Kaiser E, Kuburas A, Russo A.  Global hRAMP1 transgene expression leads to an unexpected loss of migraine-like behavior from the nervous system hRAMP1 mice.  Society for Neuroscience Abstracts.  2009. 

Marquez de Prado  B, Hammond D, Russo A.  Induction of mechanical allodynia by central calcitonin gene-related peptide in a possible migraine model.  Journal of Pain.  2009. 10(S24).

Russo A.  Mice shed light on photophobia and migraine.  Nature Rev Neurology .  2009. 5(465).

White S, Marquez de Prado  B, Russo A, Hammond D.  Nociceptive sensitivity and actions of calcitonin gene related peptide (CGRP) in a mouse model of neurofibromatosis (NF).  Society for Neuroscience Abstracts.  2009. 

Kaiser E, Recober A, Kuburas A, Zhang Z, Walsh S, Thedens D, Boles Ponto  L, Magnotta V, Sunderland J, Russo A.  Parameters for light aversive behavior and initial neuroimaging studies in a murine migraine model sensitive to CGRP.  Cephalalagia.  2009. 29(PO 260).

Park K, Russo A.  Potential role of distal regulatory elements in ubiquitous induction of the calcitonin/calcitonin gene-related peptide (CALCA) gene in sepsis.  FASEB Journal.  2009. 23(660):9.

Kaiser E, Recober A, Kuburas A, Zhang Z, Walsh S, Thedens D, Boles Ponto  L, Magnotta V, Sunderland J, Russo A.  Preliminary neuroimaging and light aversive behavioral parameters using a potential migraine mouse model.  Society for Neuroscience Abstracts.  2009. 

Russo A.  RAMPing up CGRP in the nervous system: Implications for migraine.  British Neuroscience Association Abstracts.  2009. 20(P86).

Russo A.  Scholarship Review.  2009. 
[Link]

Russo A, Regan  J, VanPutte  C.  Seeley’s Essentials of Anatomy and Physiology.  7. McGraw-Hill Higher Education, New York, NY;  2009.

Kaiser E, Recober A, Zhang Z, Raddant A, Russo A.  Targeting CGRP actions in vivo: Neuroimaging and complimentary genetics in a murine migraine model.  Health Sciences Research Week, University of Iowa.  2009. 

Russo A, Kuburas A, Kaiser E, Raddant A, Recober A.  A Potential Preclinical Migraine Model: CGRP-Sensitized Mice..  Molecular and cellular pharmacology.  2009 January 1. 1(5):264-270.
[PubMed]

Park K, Russo A.  Control of the calcitonin gene-related peptide enhancer by upstream stimulatory factor in trigeminal ganglion neurons..  The Journal of biological chemistry.  2008 February 29. 283(9):5441-51.
[PubMed]

Recober A, Kuburas A, Zhang Z, Russo A.  A potential migraine model: hRAMP1 transgenic mouse.  Society for Neuroscience.  2008. 

Russo A, Seeley  R, Stephens  T, Tate  P.  Anatomy and Physiology.  8. McGraw-Hill Higher Education;  2008.

Russo A, van Otterloo E, Kaiser E, Kuburas A, Zhang Z.  Can we develop a mouse model for migraine?.  Neuropeptides.  2008. 42(467).

Recober A, Kuburas A, Zhang Z, Russo A.  Developing a potential migraine mouse model: hRAMP1 transgenic mice.  American Academy of Neurology 60th Annual Meeting.  2008. 

Chrissobolis S, Zhang Z, Lynch C, Kinzenbaw D, Russo A, Faraci F.  Receptor activity modifying protein-1 (RAMP1) overexpression selectively enhances calcitonin gene-related peptide-induced vasodilation.  FASEB Journal.  2008. 22(1151):3.

Recober A, Russo A.  Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment..  IDrugs : the investigational drugs journal.  2007 August 1. 10(8):566-74.
[PubMed]

Russo A.  Potential role for key protein in migraine.  2007 May. 

Zhang Z, Winborn C, de Marquez Prado B, Russo A.  Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2007 March 7. 27(10):2693-703.
[PubMed]

Russo A, Recober  A.  Advent of a new generation of anti-migraine medications.  Hoboken: John Wiley & Sons, Inc. .  2007. 

Recober A, Kuburas A, Zhang A, Russo A.  Developing a potential migraine mouse model.  Society for Neuroscience Abstracts.  2007. 

Russo A, van Otterloo  E, Kaiser E, Kuburas A, Zhang Z.  Genetic enhancement of CGRP actions: a possible migraine model?.  Cephalagia.  2007. 27(624).

Chrissobolis S, Zhang Z, Lynch C, Russo A, Faraci F.  Overexpression of receptor activity modifying protein 1 (RAMP1) enhances calcitonin gene-related peptide-induced vasodilation in the cerebral circulation.  FASEB Journal.  2007. A1384.

Russo A.  Ramping it up: RAMP1 and the implications for migraine.  2007. 8:687-690 .
[PubMed]

Zhang Z, Chrissobolis S, Faraci F, Russo A.  Ramping up CGRP functions in RAMP1 transgenic mice.  Society for Neuroscience Abstracts.  2007. 

Park K, Russo A.  Transcriptional activation of the neuropeptide CGRP by upstream stimulatory factor.  Society for Neuroscience Abstracts.  2007. 

Zhang Z, Dickerson I, Russo A.  Calcitonin gene-related peptide receptor activation by receptor activity-modifying protein-1 gene transfer to vascular smooth muscle cells..  Endocrinology.  2006 April 1. 147(4):1932-40.
[PubMed]

Bellamy J, Bowen E, Russo A, Durham P.  Nitric oxide regulation of calcitonin gene-related peptide gene expression in rat trigeminal ganglia neurons..  The European journal of neuroscience.  2006 April 1. 23(8):2057-66.
[PubMed]

Russo A.  Research Briefs.  2006 March. 

Saadi I, Toro R, Kuburas A, Semina E, Murray J, Russo A.  An unusual class of PITX2 mutations in Axenfeld-Rieger syndrome..  Birth defects research. Part A, Clinical and molecular teratology.  2006 March 1. 76(3):175-81.
[PubMed]

Russo A, Dickerson  I.  CGRP: A multifunctional neuropeptide.  Springer.  2006. 

Kaiser E, Van Otterloo E, Marquez de Prado B, Russo A.  Preliminary Studies in the Development of a Mouse Migraine Model.  Medical Student Research Day, University of Iowa.  2006. 

de Prado B, Russo A.  CGRP receptor antagonists: A new frontier of anti-migraine medications..  Drug discovery today. Therapeutic strategies.  2006 January 1. 3(4):593-597.
[PubMed]

Bowen E, Schmidt T, Firm C, Russo A, Durham P.  Tumor necrosis factor-alpha stimulation of calcitonin gene-related peptide expression and secretion from rat trigeminal ganglion neurons..  Journal of neurochemistry.  2006 January 1. 96(1):65-77.
[PubMed]

Seboek D, Firm C, Linscheid P, Zulewski H, Russo A, Keller U, Müller B.  Lentiviral vectors efficiently transduce mature human adipocytes.  Endocrine Society Abstracts.  2005. 

Russo A, Gagel  R.  Vitamin D control of the calcitonin gene in thyroid C cells.  Elsevier Academic Press.  2005. 

Toro R, Saadi I, Kuburas A, Nemer M, Russo A.  Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A..  The Journal of biological chemistry.  2004 December 10. 279(50):52087-94.
[PubMed]

Viney T, Schmidt T, Gierasch W, Sattar A, Yaggie R, Kuburas A, Quinn J, Coulson J, Russo A.  Regulation of the cell-specific calcitonin/calcitonin gene-related peptide enhancer by USF and the Foxa2 forkhead protein..  The Journal of biological chemistry.  2004 November 26. 279(48):49948-55.
[PubMed]

Trembath D, Semina E, Jones D, Patil S, Qian Q, Amendt B, Russo A, Murray J.  Analysis of two translocation breakpoints and identification of a negative regulatory element in patients with Rieger's syndrome..  Birth defects research. Part A, Clinical and molecular teratology.  2004 February 1. 70(2):82-91.
[PubMed]

Durham P, Dong P, Belasco K, Kasperski J, Gierasch W, Edvinsson L, Heistad D, Faraci F, Russo A.  Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons..  Brain research.  2004 January 30. 997(1):103-10.
[PubMed]

Berryman C, Dong P, Marquez DePrado B, Russo A.  Identification of GABAergic machinery in trigeminal ganglia neurons.  51st Annual Meeting of the American Association for Dental Research (AADR), Iowa Section.  2004. 

Berryman C, Dong P, Marquez de Prado B, Russo A.  Identification of GABAergic Machinery in Trigeminal Ganglia Neurons.  The IADR/AADR/CADR 82nd General Session, #1181.  2004. 

Russo A, Viney T, Schmidt T, Dong P, Zhang Z, Firm C, Dickerson I, Durham P.  Targeted Regulation of CGRP Gene Expression.  Neuropeptides.  2004. 

Liu K, Russo A, Hsiung S, Adlersberg M, Franke T, Gershon M, Tamir H.  Calcium receptor-induced serotonin secretion by parafollicular cells: role of phosphatidylinositol 3-kinase-dependent signal transduction pathways..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2003 March 15. 23(6):2049-57.
[PubMed]

Saadi I, Kuburas A, Engle J, Russo A.  Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome..  Molecular and cellular biology.  2003 March 1. 23(6):1968-82.
[PubMed]

Shaw P, Zhang X, Russo A, Amendt B, Henderson S, Williams V.  Homeobox protein, Hmx3, in postnatally developing rat submandibular glands..  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.  2003 March 1. 51(3):385-96.
[PubMed]

Durham P, Russo A.  Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2003 February 1. 23(3):807-15.
[PubMed]

Dong P, Durham P, Russo A.  CGRP and calcium signaling in rat trigeminal ganglia neurons.  Society for Neuroscience Abstracts.  2003. 

Kuburas A, Saadi I, Engle J, Russo A.  Cooperative DNA binding of the PITX2 homeodomain protein.  FASEB Journal.  2003. 17(A589).

Russo A, Jongeling A, Marquez de Prado B, Kasperski J, Bui J, Dong P, Dickerson I.  Feedback regulation of CGRP release from cultured trigeminal ganglia neurons.  Regulatory Peptides.  2003. 110(152).

Engle J, Saadi I, Kuburas A, Russo A.  Identification and characterization of PIASy interaction with the PITX2 homeodomain protein.  FASEB Journal.  2003. 17(A589).

Toro R, Saadi I, Kuburas A, Russo A.  PITX2 and MEF2A synergistically activate the ANF promoter.  FASEB Journal.  2003. 17(A591).

Dong P, Durham P, Marquez de Prado B, Russo A.  Regulation of intracellular Ca2+ in trigeminal neurons by an antimigraine drug.  FASEB Journal.  2003. 17(A607).

Mora S, Durham P, Smith J, Russo A, Jeromin A, Pessin J.  NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway..  The Journal of biological chemistry.  2002 July 26. 277(30):27494-500.
[PubMed]

Russo A, Durham P.  Targeted regulation of CGRP: Implications for migraine.  Proceedings Physiology Society.  2002 July. 16P.

Durham P, Russo A.  New insights into the molecular actions of serotonergic antimigraine drugs..  Pharmacology & therapeutics.  2002 April 1. 94(1-2):77-92.
[PubMed]

Saadi I, Kuburas A, Russo A.  PITX2 and MEF2A synergistically activate the ANF promoter.  American Journal of Human Genetic.  2002. 71(335).

Russo A, Quast B, Billaud M.  Potential therapeutic strategies for medullary thyroid carcinoma.  Regulatory Peptides.  2002. 103(150).

Dong P, Russo A.  Regulation of intracellular calcium in a neuron-like cell line by 5-HT1 agonists.  Neuroscience Society Abstracts.  2002. 

Durham P, Russo A.  Stimulation of CGRP secretion from trigeminal ganglia neurons by the TNF-a-sphingosine-ceramide pathway.  Neuroscience Society Abstracts.  2002. 

Tamir H, Liu K, Russo A, Hsiung S, Adlersberg M, Gershon M.  Transduction pathways of serotonin secretion from parafollicular cells of the thyroid induced by a G-protein-coupled plasmalemmal calcium receptor.  Neuroscience Society Abstracts.  2002. 

Saadi I, Semina E, Amendt B, Harris D, Murphy K, Murray J, Russo A.  Identification of a dominant negative homeodomain mutation in Rieger syndrome..  The Journal of biological chemistry.  2001 June 22. 276(25):23034-41.
[PubMed]

Wood J, Russo A.  Autoregulation of cell-specific MAP kinase control of the tryptophan hydroxylase promoter..  The Journal of biological chemistry.  2001 June 15. 276(24):21262-71.
[PubMed]

Tamir H, Liu K, Russo A, Hsuing S, Adlersberg M, Gershon M.  5-HT secretion induced by a G-protein coupled receptor (CaR) for extracellular Ca2+.  Neuroscience Society Abstracts.  2001. 27(701.4).

Toro R, Saadi I, Jin Y, Condie B, Russo A.  Characterization of PITX2 Rieger syndrome mutations in C elegans.  American Journal of Human Genetic.  2001. 69(1038).

Saadi I, Kuburas A, Russo A.  Molecular characterization of a Rieger syndrome nonsense mutation in PITX2.  American Journal of Human Genetic.  2001. 69(1099).

Kuburas A, Saadi I, Russo A.  PITX2 homeodomain protein forms a dimer: Insights from natural and synthetic mutations.  American Journal of Human Genetic.  2001. 69(1090).

Durham P, Russo A.  Regulation of CGRP gene expression in primary trigeminal ganglia neurons by nitric oxide.  Neuroscience Society Abstracts.  2001. 27(477.17).

Russo A, Durham P.  Targeted regulation of CGRP gene expression.  Scientific World Journal .  2001. 1(5).

Russo A, Faraci F, Heistad D, Durham P.  Targeted regulation of CGRP neuropeptide levels: Potential for neurovascular gene therapy.  Regulatory Peptides.  2001. 97(65).

Green P, Hjalt T, Kirk D, Sutherland L, Thomas B, Sharpe P, Snead M, Murray J, Russo A, Amendt B.  Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development..  Gene expression.  2001 January 1. 9(6):265-81.
[PubMed]

Durham P, Russo A.  Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal..  Molecular endocrinology.  2000 October 1. 14(10):1570-82.
[PubMed]

Toyoda K, Faraci F, Russo A, Davidson B, Heistad D.  Gene transfer of calcitonin gene-related peptide to cerebral arteries..  American journal of physiology. Heart and circulatory physiology.  2000 February 1. 278(2):H586-94.
[PubMed]

Saadi I, Semina E, Harris D, Murphy K, Murray J, Russo A.  Identification of a dominant negative Rieger syndrome mutation in PITX2.  American Journal of Human Genetic.  2000. 67(188).

Saadi I, Toro R, Condie B, Russo A.  Molecular characterization of PITX2 mutations in non-neuronal and neuronal cells.  Neuroscience Society Abstracts .  2000. 26(608.4).

30. Durham P, Russo A.  Regulation of calcium levels by 5-HT1 receptor activation: Implications for migraine therapy.  Neuroscience Society Abstracts .  2000. 26(145.13).

Russo A, Durham P.  Regulation of CGRP gene expression: Or how to get a headache.  Regulatory Peptides.  2000. 86(20).

Rind H, Russo A, Whittemore S.  Developmental regulation of tryptophan hydroxylase messenger RNA expression and enzyme activity in the raphe and its target fields..  Neuroscience.  2000 January 1. 101(3):665-77.
[PubMed]

Amendt B, Sutherland L, Russo A.  Multifunctional role of the Pitx2 homeodomain protein C-terminal tail..  Molecular and cellular biology.  1999 October 1. 19(10):7001-10.
[PubMed]

Durham P, Russo A.  Regulation of calcitonin gene-related peptide secretion by a serotonergic antimigraine drug..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  1999 May 1. 19(9):3423-9.
[PubMed]

Amendt B, Sutherland L, Russo A.  Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site..  The Journal of biological chemistry.  1999 April 23. 274(17):11635-42.
[PubMed]

Rind H, Russo A, Whittemore S.  Developmental regulation of TPH mRNA expression and enzyme activity in the raphe and its target fields: evidence for postnatal raphe neuronal death?.  Neuroscience Society Abstracts.  1999. 25(516).

Toyoda K, Faraci F, Russo A, Davidson B, Heistad D.  Gene transfer of calcitonin gene-related peptide alters reactivity of cerebral arteries.  Stroke.  1999. 30(239).

Durham P, Russo A.  Inhibition of neuropeptide gene expression by sustained elevation of intracellular calcium.  Neuroscience Society Abstracts.  1999. 25(1810).

Saadi I, Murphy K, Russo A.  Molecular characterization of a Rieger syndrome mutation in PITX2.  American Journal of Human Genetic.  1999. 65(A379).

Amendt B, Sutherland L, Semina E, Russo A.  The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities..  The Journal of biological chemistry.  1998 August 7. 273(32):20066-72.
[PubMed]

Durham P, Russo A.  Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer..  Molecular endocrinology.  1998 July 1. 12(7):1002-9.
[PubMed]

Clark M, Russo A.  Measurement of tryptophan hydroxylase mRNA levels by competitive RT-PCR..  Brain research. Brain research protocols.  1998 June 1. 2(4):273-85.
[PubMed]

Siuciak J, Clark M, Rind H, Whittemore S, Russo A.  BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain..  Journal of neuroscience research.  1998 April 15. 52(2):149-58.
[PubMed]

Lanigan T, DeRaad S, Russo A.  Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells..  Journal of neurobiology.  1998 February 5. 34(2):126-34.
[PubMed]

Belasco K, Toyoda K, Faraci F, Davidson B, Durham P, Russo A, Heistad D.  Expression of calcitonin gene-related peptide following adenovirus-mediated gene transfer to COS cells.  FASEB Journal.  1998. 12(A674).

Qian X, Lanigan T, Russo A.  Identification of a protein kinase that interacts with nuclear receptors.  Endocrine Society Abstracts.  1998. 80:477-478 .

Durham P, Russo A.  Inhibition of CGRP secretion by 5-HT1 antimigraine drugs.  Neuroscience Society Abstracts .  1998. 24(772).

Russo A.  Neuronal differentiation of cranial-crest derived thyroid C-cells.  CRC Press.  1998. 

Durham P, Russo A.  Serotonergic repression of MAP kinase control of the CGRP enhancer.  Endocrine Society Abstracts.  1998. 80(343).

Amendt B, Sutherland L, Murray J, Russo A.  The molecular basis of Rieger syndrome: Analysis of Pitx2 homeobox activities.  Endocrine Society Abstracts.  1998. 80(111).

Durham P, Sharma R, Russo A.  Repression of the calcitonin gene-related peptide promoter by 5-HT1 receptor activation..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  1997 December 15. 17(24):9545-53.
[PubMed]

Clark M, Russo A.  Tissue-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels..  Brain research. Molecular brain research.  1997 September 1. 48(2):346-54.
[PubMed]

Lanigan T, Russo A.  Binding of upstream stimulatory factor and a cell-specific activator to the calcitonin/calcitonin gene-related peptide enhancer..  The Journal of biological chemistry.  1997 July 18. 272(29):18316-24.
[PubMed]

Amendt B, Sutherland L, Semina E, Murray J, Russo A.  Characterization of Solurshin, a novel bicoid homeobox transcription factor involved in Reiger syndrome.  Endocrine Society Abstracts.  1997. 79(565).

Lanigan T, Russo A.  Combinatorial control of the calcitonin/CGRP enhancer by the USF helix-loop-helix protein and a cell-specific coactivator.  Endocrine Society Abstracts.  1997. 79(565).

Durham P, Russo A.  Serotonergic repression of calcitonin gene-related peptide gene expression.  Endocrine Society Abstracts.  1997. 79(568).

Durham P, Russo A.  Serotonergic repression of calcitonin gene-related peptide gene expression: Elucidation of molecular mechanism.  Neuroscience Society Abstracts.  1997. 23(1670).

Russo A, Clark M, Durham P.  Thyroid parafollicular cells. An accessible model for the study of serotonergic neurons..  Molecular neurobiology.  1996 December 1. 13(3):257-76.
[PubMed]

Tamir H, Hsiung S, Liu K, Blakely R, Russo A, Clark M, Nunez E, Gershon M.  Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells..  Endocrinology.  1996 October 1. 137(10):4475-86.
[PubMed]

Clark M, Russo A.  Cell-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels in the brain.  Society for Neuroscience Abstracts.  1996. 22(1442).

Tamir H, Liu K, Hsuing S, Blakely R, Russo A, Clark M, Gershon M.  Expression, function, and development of a 5-HT transporter (SERT) in the plasma membrane of thyroid follicular cells.  Society for Neuroscience Abstracts.  1996. 22(615).

Russo A, Lanigan  T.  Neuronal properties of thyroid C-cell tumor lines.  Landes Co..  1996. 

Lanigan T, Russo A.  Role of MASH-1 in thyroid C cell differentiation and gene expression.  Society for Neuroscience Abstracts.  1996. 22(28).

Durham P, Pantazis N, Russo A.  Serotonergic repression of calcitonin gene-related peptide gene expression.  Society for Neuroscience Abstracts.  1996. 22(1592).

Clark M, Lanigan T, Page N, Russo A.  Induction of a serotonergic and neuronal phenotype in thyroid C-cells..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  1995 September 1. 15(9):6167-78.
[PubMed]

Clark M, Lanigan T, Russo A.  Serotonergic Neuronal Properties in C-Cell Lines.  Methods.  1995 June. 7(3):253–261.
[Link]

Russo A, Green  S.  Editorial: Neuronal cell lines.  1995. 7:219-221.

Russo A.  Retinoids: From basic science to clinical applications. Molecular and cell biology updates.  1995. 70(542).

Russo A.  Calcitonin gene-related peptide. The first decade of a novel pleiotropic neuropeptide.  1994. 84(127).

Michalchik M, Russo A.  Characterization of the extracellular calcium receptor in rat thyroid C-cells.  Society for Neuroscience Abstracts.  1994. 20(67).

Tompach P, Daniels K, Russo A.  Construction of a cranial neural crest cDNA library.  Journal of Oral and Maxillofacial Surgery.  1994. 52(158).

Clark M, Johnson W, Russo A.  Dexamethasone repression of tryptophan hydroxylase mRNA levels in the CA77 C-cell line.  Society for Neuroscience Abstracts.  1994. 20(289).

Russo A.  Neurotrophic factors .  1994. 93:480-481.

Lanigan T, Tverberg L, Russo A.  Retinoic acid repression of cell-specific helix-loop-helix-octamer activation of the calcitonin/calcitonin gene-related peptide enhancer..  Molecular and cellular biology.  1993 October 1. 13(10):6079-88.
[PubMed]

Tverberg L, Russo A.  Regulation of the calcitonin/calcitonin gene-related peptide gene by cell-specific synergy between helix-loop-helix and octamer-binding transcription factors..  The Journal of biological chemistry.  1993 July 25. 268(21):15965-73.
[PubMed]

Crawford J, Mutchler K, Sullivan B, Lanigan T, Clark M, Russo A.  Neural expression of a novel alternatively spliced and polyadenylated Gs alpha transcript..  The Journal of biological chemistry.  1993 May 5. 268(13):9879-85.
[PubMed]

Russo A, Tverberg L.  Neuroendocrine-specific transcription of the calcitonin/CGRP gene involves synergy between an HLH factor and an associated factor.  Journal of Cellular Biochemistry (supplement).  1993. 17D(267).

Chen Y, Huang L, Russo A, Solursh M.  Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo..  Proceedings of the National Academy of Sciences of the United States of America.  1992 November 1. 89(21):10056-9.
[PubMed]

Tverberg L, Russo A.  Cell-specific glucocorticoid repression of calcitonin/calcitonin gene-related peptide transcription. Localization to an 18-base pair basal enhancer element..  The Journal of biological chemistry.  1992 September 5. 267(25):17567-73.
[PubMed]

Mutchler K, Klemish S, Russo A.  A rapid PCR protocol for identification of differentially expressed genes from a cDNA library..  PCR methods and applications.  1992 February 1. 1(3):195-8.
[PubMed]

Russo A, Lanigan T, Sullivan B.  Neuronal properties of a thyroid C-cell line: partial repression by dexamethasone and retinoic acid..  Molecular endocrinology.  1992 February 1. 6(2):207-18.
[PubMed]

Chen Y, Huang L, Russo A, Solursh M.  Hensen’s node is a source of retinoic acid in the early chick embryo.  Anatomical Record.  1992. 232(19a).

Lanigan T, Crawford J, Russo A.  Induction of a novel truncated G protein mRNA upon differentiation of a thyroid C cell line.  Endocrine Society Abstracts.  1992. 

Russo A, Crenshaw  E, Swanson  L, Rosenfeld  M.  Transgenic Mouse Technology: Application to the Study of the Nervous System.  Elsevier.  1992. 

Russo A, Chamany K, Klemish S, Hall T, Murray J.  Characterization of the calcitonin/CGRP gene in Williams syndrome..  American journal of medical genetics.  1991 April 1. 39(1):28-33.
[PubMed]

Tverberg L, Russo A.  Glucocorticoid regulation of the calcitonin/CGRP gene in transfected cell lines.  Endocrine Society Abstracts.  1991. 

Russo A, Soulati A, Tverberg L.  Cell-specific glucocorticoid regulation of calcitonin/CGRP gene expression.  Endocrine Society Abstracts.  1990. 

Li  S, Klein E, Russo A, Simmons D, Rosenfeld M.  Isolation of cDNA clones encoding small nuclear ribonucleoparticle-associated proteins with different tissue specificities..  Proceedings of the National Academy of Sciences of the United States of America.  1989 December 1. 86(24):9778-82.
[PubMed]

Russo A, Crenshaw, 3rd E, Lira S, Simmons D, Swanson L, Rosenfeld M.  Neuronal expression of chimeric genes in transgenic mice..  Neuron.  1988 June 1. 1(4):311-20.
[PubMed]

Russo A, Nelson C, Roos B, Rosenfeld M.  Differential regulation of the coexpressed calcitonin/alpha-CGRP and beta-CGRP neuroendocrine genes..  The Journal of biological chemistry.  1988 January 5. 263(1):5-8.
[PubMed]

Rosenfeld M, Crenshaw, 3rd E, Emeson R, Leff S, Guise J, Lira S, Nelson C, Nelson C, Russo A.  Transcriptional and post-transcriptional strategies in neuroendocrine gene expression..  Developmental biology (New York, N.Y. : 1985).  1988 January 1. 5:317-34.
[PubMed]

Crenshaw, 3rd E, Russo A, Swanson L, Rosenfeld M.  Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene..  Cell.  1987 May 8. 49(3):389-98.
[PubMed]

Rosenfeld M, Leff S, Russo A, Evans R.  Neuron-specific alternative RNA processing in neuroendocrine gene expression..  Biochemical Society transactions.  1987 February 1. 15(1):128-31.
[PubMed]

Russo A, Leff  S, Evans  R, Rosenfeld  M.  Alternative RNA processing events in calcitonin/CGRP gene expression: A strategy for developmental regulation of neuroendocrine gene expression.  Japan Scientific Societies Press.  1987. 

Russo A, Rosenfeld  M, Leff  S, Crenshaw  E, Ahearn  K.  Developmental control of a calcium-regulating neuroendocrine gene.  Academic Press.  1987. 

Russo A, Rosenfeld  M, Leff  S, Evans  R.  Neuron-specific alternative RNA processing in neuroendocrine gene expression.  1987. 15:128-131.
[PubMed]

Russo A, Rosenfeld  M, Leff  S, Crenshaw  E, Nelson  C, Franco  R, Lira  S, Evans  R.  Regulation of neuroendocrine gene expression.  1987. 52:369-378.

Russo A, Leff  S, Nelson  C, Crenshaw  E, Elsholtz  H, Mangalam  H, Evans  R, Rosenfeld  M.  Transcriptional and post-transcriptional regulation of neuroendocrine gene expression.  ICSU Short Reports.  1986. 4:6-9.

Russo A, Rosenfeld  M, Leff  S, Evans  R.  Transcriptional control of neuroendocrine genes.  1986. 

Russo A, DE Koshland, Jr .  Identification of the tip-encoded receptor in bacterial sensing..  Journal of bacteriology.  1986 January 1. 165(1):276-82.
[PubMed]

Russo A, Koshland Jr  D.  Receptor modification and absolute adaptation in bacterial sensing.  Elsevier Science Publishers.  1985. 

Russo A, Aline Jr. R, Reeves C, Volcani B.  Role of silicon in diatom metabolism: Cyclic nucleotide levels, nucleotide cyclase, and phosphodiesterase activities during synchronized growth of Cylindrotheca fusiformis.  Plant Physiology.  1984. 76:674-679.
[PubMed]

Russo A, Koshland Jr. D.  Separation of signal transduction and adaptation functions of the aspartate receptor in bacterial sensing.  Science.  1983. 220:1016-1020.
[PubMed]

Russo A, Koshland Jr D.  Structure-function relationships of the chemotaxis aspartate receptor.  (FASEB Meeting) Federation Proceedings.  1983. 42(2136).

DE Koshland, Jr , Russo A, Gutterson N.  Information processing in a sensory system..  Cold Spring Harbor symposia on quantitative biology.  1983 January 1. 48 Pt 2:805-10.
[PubMed]

Clegg D, Wang E, Russo A, Koshland Jr D.  Evolution of receptors in bacterial chemotaxis.  (UCLA Symposia) Journal of Cellular Biochemistry.  1982. 6(174).

Russo A, Recober  A, Zhang  Z, Marquez de Prado  B, Kaiser  E, Kuburas  A.  Biological relevance of CGRP in the context of migraine.  Oxford University Press; 

Date Last Modified: 06/06/2016 - 13:17:48