Nandakumar Narayanan, MD, PhD


Specialty: Parkinson's Disease
Assistant Director: Clinical Neuroscientist Training Program in Neurology
Assistant Director: Residency Program in Neurology
Assistant Professor of Neurology

Contact Information

Primary Office: 1336 PBDB
Iowa City, IA 52242
Phone: 319-356-4757

Web: Narayanan Laboratory


BA, Human Biology, Stanford University
MD, Medicine, Yale University
PhD, Neuroscience, Yale University

Internship, Medicine, Hospital of St. Raphael
Residency, Neurology, Yale Medical School
Post Doctorate, Yale Medical School

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

The specific problem we are interested is cognitive dysfunction in Parkinsons disease. Our current research focuses on the influence of dopamine on prefrontal networks controlling cognitive behaviors such as timing and performance monitoring. We combine ensemble recording from populations of neurons in awake, behaving animals with specific manipulations using techniques such as optogenetic stimulation, targeted pharmacology, or selective genetic disruption with RNA interference. We hope to identify new treatment strategies that can be translated to a clinical setting.

Center, Program and Institute Affiliations

Aging Mind and Brain Initiative

All Publications

Johnson S, Emmons E, Anderson R, Glanz R, Romig-Martin S, Narayanan N, LaLumiere R, Radley J.  A Basal Forebrain Site Coordinates the Modulation of Endocrine and Behavioral Stress Responses via Divergent Neural Pathways..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2016 August 17. 36(33):8687-99.

Huff M, Emmons E, Narayanan N, LaLumiere R.  Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats..  Learning & memory (Cold Spring Harbor, N.Y.).  2016 January 15. 23(2):51-60.

Parker K, Chen K, Kingyon J, Cavanagh J, Narayanan N.  Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion..  Journal of neurophysiology.  2015 August 1. 114(2):1310-20.

Parker K, Ruggiero R, Narayanan N.  Infusion of D1 Dopamine Receptor Agonist into Medial Frontal Cortex Disrupts Neural Correlates of Interval Timing..  Frontiers in behavioral neuroscience.  2015 January 1. 9:294.

Narayanan N, Cavanagh J, Frank M, Laubach M.  Common medial frontal mechanisms of adaptive control in humans and rodents..  Nature neuroscience.  2013 December 1. 16(12):1888-95.

Fattahi P, Sheriff F, Narayanan N, Greer D, Schindler J.  Thrombolysis for acute stroke in patients with vasculitis: case report and literature discussion..  Clinical neurology and neurosurgery.  2013 March. 115(3):351-3.

Narayanan N, Land B, Solder J, Deisseroth K, DiLeone R.  Prefrontal D1 dopamine signaling is required for temporal control..  Proceedings of the National Academy of Sciences of the United States of America.  2012 December. 109(50):20726-31.

Narayanan N, Sheriff F, Boyce J.  Teaching NeuroImages: CNS actinomycosis in an immunocompetent patient..  Neurology.  2012 September. 79(10):e85.

Salardini A, Narayanan N, Arora J, Constable T, Jabbari B.  Ipsilateral synkinesia involves the supplementary motor area..  Neuroscience letters.  2012 August. 523(2):135-8.

Prabhakaran V, Rypma B, Narayanan N, Meier T, Austin B, Nair V, Naing L, Thomas L, Gabrieli J.  Capacity-speed relationships in prefrontal cortex..  PloS one.  2011. 6(11):e27504.

Sears R, Liu R, Narayanan N, Sharf R, Yeckel M, Laubach M, Aghajanian G, DiLeone R.  Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2010 June. 30(24):8263-73.

Narayanan N, Guarnieri D, DiLeone R.  Metabolic hormones, dopamine circuits, and feeding..  Frontiers in neuroendocrinology.  2010 January. 31(1):104-12.

Smith N, Narayanan N, Laubach M.  Past performance is indicative of future returns..  Neuron.  2009 July. 63(2):146-8.

Narayanan N, Laubach M.  Delay activity in rodent frontal cortex during a simple reaction time task..  Journal of neurophysiology.  2009 June. 101(6):2859-71.

Narayanan N, Laubach M.  Methods for studying functional interactions among neuronal populations..  Methods in molecular biology (Clifton, N.J.).  2009. 489:135-65.

Narayanan N, Laubach M.  Neuronal correlates of post-error slowing in the rat dorsomedial prefrontal cortex..  Journal of neurophysiology.  2008 July. 100(1):520-5.

Allen T, Narayanan N, Kholodar-Smith D, Zhao Y, Laubach M, Brown T.  Imaging the spread of reversible brain inactivations using fluorescent muscimol..  Journal of neuroscience methods.  2008 June. 171(1):30-8.

Narayanan N, Laubach M.  Top-down control of motor cortex ensembles by dorsomedial prefrontal cortex..  Neuron.  2006 December. 52(5):921-31.

Narayanan N, Horst N, Laubach M.  Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus..  Neuroscience.  2006. 139(3):865-76.

Luczak A, Narayanan N.  Spectral representation--analyzing single-unit activity in extracellularly recorded neuronal data without spike sorting..  Journal of neuroscience methods.  2005 May. 144(1):53-61.

Narayanan N, Kimchi E, Laubach M.  Redundancy and synergy of neuronal ensembles in motor cortex..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2005 April. 25(17):4207-16.

Narayanan N, Prabhakaran V, Bunge S, Christoff K, Fine E, Gabrieli J.  The role of the prefrontal cortex in the maintenance of verbal working memory: an event-related FMRI analysis..  Neuropsychology.  2005 March. 19(2):223-32.

Narayanan N, PRABHAKARAN V, BUNGE S, CHRISTOF K, FINE E, GABRIELI J.  Parametric manipulation of the amount of information in working memory.  Neuropsychology.  2005. 19(2):4207-16.

Narayanan N, KIMCHI E, LAUBACH M.  Redundancy and synergy of neuronal ensembles in motor cortex.  j. nEUROSCI..  2005. 25(17):4207-16.

Narayanan N.  Between Worlds: Guardian deities as agents of transformation.  Stanford Journal of East Asian Affairs.  2002. 2(1):41-54.

PRABHAKARAN V, Narayanan N, ZHAO Z, GABRIELI J.  Integration of diverse information in working memory within the frontal lobe.  Nat Neurosci.  2000. 3(1):85-90.

Prabhakaran V, Narayanan K, Zhao Z, Gabrieli J.  Integration of diverse information in working memory within the frontal lobe..  Nature neuroscience.  2000 January. 3(1):85-90.

LUCZAK A, Narayanan N.  Spectral representation – analyzing single-unit activity in extracellularly recorded neuronal data without spike sorting.  J Neurosci Methods.  144(1):53-61.

Date Last Modified: 09/23/2016 - 15:07:07