Enrique Leira, MD, MS


Specialty: Stroke
Associate Professor of Neurology

Contact Information

Primary Office: 2147 RCP
Iowa City, IA 52242
Phone: 319-356-8755



MD, Universidad de Santiago de Compostela
MS, Epidemiology, University of Iowa

Fellowship, Cerebrovascular Diseases, University of Iowa
Residency, St. Louis University

Research Summary

Enrique Leira MD MS specializes in Cerebrovascular Diseases and Epidemiology. His research focus is acute stroke management, including evidence-based strategies to improve and accelerate stroke treatment in rural areas. There is an unacceptable disparity in acute stroke practices between urban tertiary centers and those 25% patients living in rural areas. The gap will be further increased as rural patients continue to be excluded from time-dependent stroke trials due to distance/time from research centers. His research interests include novel strategies to enable participation of patients living in rural areas in acute trials testing stroke therapies, such as randomization before arrival to the University while they are being transported in a helicopter ambulance. Dr. Leira is also interested in designing novel forms of integrated physiological monitoring for stroke patients in order to modernize the current practice of performing gross "neurochecks" by nurses. The goal is to improve the beneficial effect of dedicated stroke units by detecting neurological deterioration in an objective, real time manner, without having to wake up the patient every few hours. He is a member of the Operator Performance laboratory in the College of Engineering. He also has an interest in aviation neurology, neurological emergencies in flight and developing real-time telecommunication solutions for the helicopter ambulances that transport stroke patients from small rural hospitals to large tertiary care centers.

Selected Publications

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Leira E, Kaskie B, Froehler M, Adams H.  The Growing Shortage of Vascular Neurologists in The Era of Health Reform: Planning is Brain!.  Stroke; a journal of cerebral circulation.  2013 March. 44(3):822-7.

Leira E, Fairchild G, Segre A, Rushton G, Froehler M, Polgreen P.  Primary stroke centers should be located using maximal coverage models for optimal access..  Stroke; a journal of cerebral circulation.  2012 September. 43(9):2417-22.

Leira E, Kaldjian L, Ludwig B, Torner J, Olalde H, Hacke W, Adams H.  Lack of international consensus on ethical aspects of acute stroke trials..  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.  2012 April. 21(3):200-4.

Leira E, Ludwig B, Gurol M, Torner J, Adams H.  The types of neurological deficits might not justify withholding treatment in patients with low total National Institutes of Health Stroke Scale scores..  Stroke; a journal of cerebral circulation.  2012 March. 43(3):782-6.

Mikami K, Jorge R, Adams H, Davis P, Leira E, Jang M, Robinson R.  Effect of antidepressants on the course of disability following stroke..  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.  2011 December. 19(12):1007-15.

Cruz-Flores S, Rabinstein A, Biller J, Elkind M, Griffith P, Gorelick P, Howard G, Leira E, Morgenstern L, Ovbiagele B, Peterson E, Rosamond W, Trimble B, Valderrama A.  Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association..  Stroke; a journal of cerebral circulation.  2011 July. 42(7):2091-116.

Day J, Policeni B, Smoker W, Dobre M, Zhang Y, Leira E, Davis P, Chen S, Olalde H, Adams H.  Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack..  Stroke; a journal of cerebral circulation.  2011 February. 42(2):354-8.

Leira E.  Treatment of acute stroke.  Revista de neurologia.  36(1):86-92.

Leira E, Cruz-Flores S, Acharya A, Pan Y.  Treatment with tissue plasminogen activator is not associated with increased use of neurosurgery..  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.  14(6):278-80.

Date Last Modified: 06/06/2016 - 13:17:48