Internal Medicine

Mark W. Chapleau, PhD


Professor of Internal Medicine  - Cardiovascular Medicine
Professor of Molecular Physiology and Biophysics

Contact Information

Primary Office: 629 MRC
Iowa City, IA 52242
Phone: 319-335-8958

Web: Deputy Editor-in-Chief USA, Experimental Physiology (EP) Editorial Board


BS, Biology/Chemistry, University of Wisconsin
PhD, Physiology, Louisiana State University Medical Center

Post Doctorate, Research, University of Iowa College of Medicine

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

Dr. Chapleau's research focuses on mechanisms of autonomic regulation in health and disease including effects of aging, hypertension, hypercholesterolemia, cardiomyopathy, myocardial infarction (MI), heart failure, and muscular dystrophy. Key hypotheses involve the roles of acid-sensing ion channels in sensory transduction, reactive oxygen species and angiotensin in sensory and sympathetic signaling, and oxidative stress in autonomic dysregulation. Experimental approaches include assessment of the cellular and molecular basis of sensory transduction and neuronal excitability in baroreceptor and sympathetic neurons using patch-clamp, imaging, and molecular techniques; recording of baroreceptor and sympathetic nerve activity in vivo; and assessment of cardiovascular and autonomic function in conscious mice using radiotelemetry.

Center, Program and Institute Affiliations

Cardiovascular Research Center
George M. O’Brien Kidney Research Center

Selected Publications

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Chapleau M, Sabharwal R.  Methods of assessing vagus nerve activity and reflexes..  Heart failure reviews.  2011 March. 16(2):109-27.

Sabharwal R, Zhang Z, Lu Y, Abboud F, Russo A, Chapleau M.  Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension..  Hypertension.  2010 March. 55(3):627-35.

Lu Y, Ma X, Sabharwal R, Snitsarev V, Morgan D, Rahmouni K, Drummond H, Whiteis C, Costa V, Price M, Benson C, Welsh M, Chapleau M, Abboud F.  The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation..  Neuron.  2009 December. 64(6):885-97.

Ma X, Bielefeldt K, Tan Z, Whiteis C, Snitsarev V, Abboud F, Chapleau M.  Dual mechanisms of angiotensin-induced activation of mouse sympathetic neurones..  The Journal of physiology.  2006 May. 573(Pt 1):45-63.

Ma X, Sigmund C, Hingtgen S, Tian X, Davisson R, Abboud F, Chapleau M.  Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice..  Hypertension.  2004 February. 43(2):312-6.

Date Last Modified: 06/06/2016 - 13:17:48