Associate Professor of Internal Medicine
- Hematology, Oncology and Blood and Marrow Transplantation
Primary Office: 3188 ML
Iowa City, IA 52242
Lab: 3120 ML
Iowa City, IA 52242
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BSc, Botany, Zoology, Chemistry, University of Delhi
MSc, Biotechnology, Devi Ahilya University
M Tech, Fermentation and Biotechnology, Anna University
Post Doctorate, Molecular Genetics, International Centre for Genetic Engineering and Biotechnology
Post Doctorate, Thrombosis and Inflammation, Immune Disease Institute and Harvard Medical School
Post Doctorate, Thrombosis and Inflammation, CBR Institute for Biomedical Research
Education/Training Program Affiliations
Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Medical Scientist Training Program
Research in laboratory is focused on the role of adhesion molecules in vascular diseases associated with thrombosis and inflammation. By using state-of-the-art technique, intravital imaging, we study the role of adhesion molecules in regulating blood cell-endothelial (platelet and leukocyte) interaction followed by stimulation/ injury in vivo. In addition, research projects uses molecular and cellular techniques, combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of acute ischemic stroke and atherosclerosis. Using murine models, we hope to understand the pathophysiology of human vascular inflammatory diseases that may lead to development of novel therapies, thus improving human health. Current research project includes: 1) Role of ADAMTS13-VWF axis in acute ischemic stroke and atherosclerosis. 2) Mechanistic role of fibronectin alternative splicing in early and advanced atherosclerosis.
Center, Program and Institute Affiliations
Holden Comprehensive Cancer Center
Red blood cells mediate the onset of thrombosis in ferric-chloride murine model.
2013 May 2. 121(18):3733-41.
ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.
2012 December 20. 120(26):5224-30.
ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice..
Journal of Thrombosis and Haemostasis.
2012 August. 10(8):1665-71.
Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice..
2012 August. 43(5):1376-82.
ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice..
2012 March. 119(10):2385-91.
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A..
2011 June. 117(23):6326-37.
von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models..
2011 January 27. 117(4):1400-7.
The function of ADAMTS13 in thrombogenesis in vivo: insights from mutant mice..
Internatiomal Journal of Hematology.
2010 January. 91(1):30-5.
von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke..
2009 October 8. 114(15):3329-34.
Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion..
2009 October. 84(1):137-44.
Date Last Modified: 06/06/2016 -