Anatomy and Cell Biology

Adam Dupuy, PhD


Associate Professor of Anatomy and Cell Biology
Associate Professor of Pathology

Contact Information

Primary Office: 3202 MERF
Iowa City, IA 52242
Phone: 319-335-8090

Web: PubMed link to publications


BA, Biology and Chemistry, Central College
PhD, Molecular, Cellular, Developmental Biology, and Genetics, University of Minnesota

Post Doctorate, University of Minnesota Cancer Center
Post Doctorate, Mouse Cancer Genetics, National Cancer Institute

Education/Training Program Affiliations

Department of Anatomy and Cell Biology Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Medical Scientist Training Program

Research Summary

The goal of my current research is to understand the role that somatic mutation plays in all aspects of tumor biology. Much of our work has made use of the Sleeping Beauty (SB) transposon system to engineer mouse cancer models in which somatic mutations are generated by transposon insertions. We and our collaborators have recently described a variety of tumor models using the approach, and these studies have identified many novel candidate cancer genes. The current work in my laboratory focuses on the genetics of hepatocellular carcinoma and T-cell leukemia. In addition, we have ongoing collaborative efforts to develop SB models of ovarian and endometrial cancer. Future work in the lab will focus on using our mouse models to address relevant questions encountered by oncologists in the clinic (e.g. metastasis, drug resistance).

Date Last Modified: 08/10/2016 - 10:11:20