Agbor, Njotu (Larry)

Njotu (Larry) Agbor, PhD

Address: 2-340 BSB
Phone: (319) 335-8926

Mentor: Curt D. Sigmund, PhD

PhD Institution: University of New Mexico, 2012

Research Description

Identification and function of PPAR-γ and PPAR-γ target genes in the blood vessel


 Ibeawuchi, S.R., Agbor, L.N., Quelle, F.W., Sigmund, C.D.:  Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.  J Biol Chem 290(31):19208-17, 2015.  PMCID: PMC4521042  Agbor, L.N., Wiest, E.F., Rothe, M., Schunck, W.H., Walker, M.K.:  Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids.  J Pharmacol Exp Ther. 351(3):688-98, 2014.  PMCID: PMC4244579  Bentson, L.F., Agbor, V.A., Agbor, L.N., Lopez, A.C., Nfonsam, L.E., Bornstein, S.S., Handel, M.A. and Linder, C.C.: New point mutation in Golga3 causes multiple defects in spermatogenesis. Andrology. 1(3):440-50, 2013. PMCID: PMC4134951Agbor, L.N., Walsh, M.T., Boberg, J.R. and Walker, M.K.: Elevated blood pressure in CYP1A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids. Toxicol Appl Pharmacol. 264(3):351-360, 2012. PMCID: PMC3494483Agbor, L.N., Elased, K.M. and Walker, M.K.: Endothelial cell-specific aryl hydrocarbon receptor knockout mice exhibit hypotension mediated, in part, by an attenuated angiotensin II responsiveness. Biochem Pharmacol. 82(5):514-23, 2011. PMCID: PMC3148414 Zhang, N., Agbor, L.N., Scott, J.A., Zalobowski, T., Elased, K.M., Trujillo, A., Duke, M.S., Wolf, V., Walsh, M.T., Born, J.L., Felton, L.A., Wang, J., Wang, W., Kanagy, N.L. and Walker, M.K.: An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice. Biochem Pharmacol. 80(2):197-204, 2010. PMCID: PMC2867364 Kopf, P.G., Scott, J.A., Agbor, L.N., Boberg, J.R., Elased, K.M., Huwe, J.K. and Walker, M.K.: Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 117(2):537-46, 2010. PMCID: PMC2940412 Lund, A.K., Agbor, L.N., Zhang, N., Baker, A., Zhao, H., Fink, G.D., Kanagy, N.L. and Walker, M.K.: Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude. Hypertension. 51(3):803-809, 2008. PMID: 18212270