Bram Slutter

Bram Slütter

Postdoctoral Research Scholar
Address: 3-501B BSB
Phone: (319) 335-9919
Email: bernard-slutter@uiowa.edu

Mentor: John Harty, PhD

PhD Institution: Leiden University, The Netherlands

Research Description

Dissecting memory CD8 T-cell responses against influenza A.
Development of novel vaccine formulations that enhance memory CD8 T-cells formation.


Bal SM*, Slütter B*, Verheul R, Bouwstra JA, Jiskoot W Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: Adjuvant- and site-dependent immunogenicity in mice. Eur J Pharm Sci. 2011 (in press).  * = both authors contributed equally to this study

Verheul RJ, Slütter B, Bal SM, Bouwstra JA, Jiskoot W, Hennink WE. Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination. J Control Release. 2011 156(1):46-52.

Bal SM, Slütter B, Jiskoot W, Bouwstra JA. Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunization. Vaccine 2011 29(23): 4025-32.

Slütter B*, Bal SM*, Zhi D, Jiskoot W, Bouwstra JA Adjuvant effect of cationic liposomes and CpG depends on administration route. Journal Controlled Release. 2011 154(2):123-30. * = both authors contributed equally to this study

Slütter B, Bal S, Que I, Kaijzel E, Löwik C, Bouwstra J, Jiskoot W. Antigen-adjuvant conjugates for nasal vaccination, an improvement over the use of nanoparticles? Mol Pharm 2010 7(6):2207-15.

Slütter B, Keijzer C, Bal S, Que I, Kaijzel E, Löwik, Mallants R, Augustijns P, Broere F, van Eden W, Jiskoot W. Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: Nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen. Vaccine, 2010 28(38):6282-91.

Slütter B and Jiskoot W. Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethly chitosan (TMC) nanoparticles for nasal vaccination. Journal Controlled Release 2010 148(1):117-21.

Slütter B, Soema PC, Ding Z, Verheul R, Hennink W, Jiskoot W. Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen. Journal Controlled Release. 2010 143(2):207-14.

Bal SM, Slütter B, van Riet E, Kruithof AC, Ding Z, Kersten GF, Jiskoot W, Bouwstra JA. Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations. Journal Controlled Release. 2010 142(3):374-83.

Slütter B*, Plapied L*, Fievez V, des Rieux A, Schneider Y, van Riet E, Jiskoot W, Préat V. Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination. Journal Controlled Release. 2009 138(2):113-21. * = both authors contributed equally to this study

Slütter B*, Hagenaars N*, Jiskoot W. Rational design of nasal vaccines. J Drug Target. 2008 16(1):1-17. * = both authors contributed equally to this study


  • Rubicon Fellowship, Netherlands Organization for Scientific Research (NWO), 2011-2013