Madison, Nia

M. Nia Madison

Postdoctoral Research Fellow
Address: 3-615 BSB
Phone: (319) 335-7612
Email: marisa-madison@uiowa.edu

Mentor: Chioma Okeoma, PhD

Undergraduate Institution: East Texas Baptist University

PhD Institution: Meharry Medical College, Nashville, TN

Research Description

Dr. M. Nia Madison, PhD, has recently discovered that human biofluid-derived exosomes and extracellular vesicles (EV) inhibit HIV infectivity, replication and transmission. She is currently working to elucidate 1) the mechanisms involved in EV-mediated restriction of infectivity and sexual transmission of retroviruses, 2) the role of EV on HIV latency and 3) the impact of host restriction factors sequestered within extracellular vesicles on HIV replication and mutagenesis.


Madison MN, Okeoma CM. 2015. Exosomes: Implications in HIV-1 pathogenesis. Invited review ‘Viruses and Exosomes’ special issue in Viruses. doi:10.3390/v70x0000x under review.

Madison MN, Jones PH, Okeoma CM. 2015. Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex. Virology, 482, 189-201.

Madison MN, Roller RJ, Okeoma CM. 2014. Human semen contains exosomes with potent anti-HIV-1 activity. Retrovirology, 11, 102.

Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. 2013. Cellular response to Trypanosoma cruzi infection induces secretion of defensin α-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infection and Immunity, 81, 4139-48.

Jones PH, Fernandez-Mahauad WD, Madison MN, Okeoma CM. 2013. BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer. Virology 444(1-2):124-39.

Jones PH, Maric M, Madison MN, Maury W, Roller RJ, Okeoma CM. 2013. BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). Virology, 438, 37-49.

Walker TN, Cimakasky LM, Coleman EM, Madison MN, Hildreth JE. 2013. Antibody against integrin lymphocyte function-associated antigen 1 inhibits HIV type 1 infection in primary cells through caspase-8-mediated apoptosis. AIDS Res Hum Retroviruses, 29, 371-83.

Villalta F, Madison MN, Kleshchenko YY, Nde PN, Lima MF. 2008. Molecular analysis of early host cell infection by Trypanosoma cruzi. Frontiers in Bioscience, 13, 3714-3734.

Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. 2007. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infection and Immunity, 75, 4780-4791.

Madison M, Kleshchenko Y, Nde P, Simmons KJ, Lima MF, Villalta F. 2007. Mechanism of Toxicity of Human Defensin a-1 against Trypanosoma cruzi. Proceedings of the 13th International Congress of Immunology. Kalil J, Cunha-Neto E, and Rizzo LV (eds). Medimond S.r.l. Press, Bologna, Italy. pp 447-451.


  • 2012-2016, National Institutes of Health/National Institute of Allergy and Infectious Diseases T32 Postdoctoral Fellowhip
  • 2015, University of Iowa, Levitt Center for Virology, Travel Award to the 34th annual American Society for Virology meeting, London, Ontario, Canada
  • 2015, Minority Trainee Research Forum Travel Award and Acres of Diamonds Award for national abstract competition and oral research presentation, March 9-13, 2015, San Diego, CA
  • 2015, AAAS Travel Award to the Emerging Researchers National (ERN) Conference in STEM, February 19-21, 2015, Washington, D.C.
  • 2015, L'Oreal USA headquarters Black History Month representative
  • 2015, NSF Committee on Institutional Collaboration (CIC) Alliance for Graduate Education and the Professoriate (AGEP) Professorial Advancement Initiative (PAI) participant
  • 2014, University of Iowa, Levitt Center for Virology, Travel Award to the 2014 American Society for Virology (ASV) 33rd Annual Meeting, Colorado State University, Fort Collins, CO
  • 2013, Cold Spring Harbor Laboratory Travel Fellowship to the 2013 meeting on Retroviruses, Cold Spring Harbor, NY
  • 2013, University of Iowa, Levitt Center for Virology, Travel Award to the 2013 meeting on Retroviruses at CSHL, Cold Spring Harbor, NY
  • 2010-2012, L'Oreal USA/AAAS/UNESCO Fellowship for Women in Sciences
  • 2011, National Institute of Cancer/Center for Cancer Research (NIC/CCR) Travel Fellowship to the 9th Annual National Postdoctoral Association (NPA) Conference, Washington, DC
  • 2011, ATHENA Young Professional Leadership Award Finalist
  • 2011, Nashville Emerging Leader Awards (NELA) Finalist
  • 2009-2011, UNCF/Merck Science Initiative Postdoctoral Fellowship
  • 2010, NIH sponsored registration to attend Research Centers in Minority Institutions (RCMI) Symposium: Bridging the Gap Between Disparity and Equity, Nashville, TN
  • 2010, National Institute of General Medical Sciences (NIGMS)/National Institutes of Health (NIH) sponsored postdoctoral travel fellowship to The 17th Annual Institute on Teaching and Mentoring, The Compact for Faculty Diversity, Tampa, FL
  • 2010, NIH/Clinical and Translational Science Award (CTSA) sponsored by Vanderbilt Institute for Clinical and Translational Research (VICTR) scholarship for proteomic analysis and identification of "Protease Mediated Generation of SEVI"
  • 2009, NIGMS/NIH/Minority Access to Research Careers (MARC) sponsored postdoctoral travel fellowship to The Society for Advancement of Chicanos/Hispanics and Native Americans in Science National Conference, Dallas, TX
  • 2009, Meharry Medical College (MMC), Office of Faculty Development sponsored postdoctoral travel fellowship to the American Society for Microbiology (ASM) Kadner Institute, Boulder, CO
  • 2009, NIGMS/NIH sponsored postdoctoral travel fellowship to the MARC/FASEB Leadership Development and Grant Writing Workshop, Virginia Beach, VA
  • 2009, Astellas Pharma Inc./Boehringer Ingelheim Pharmaceuticals, Inc./Forest Laboratories, Inc. sponsored postdoctoral travel fellowship to The 49th Interscience Conference on Antimicrobial Agents and Chemotherapeutics, San Francisco, CA
  • 2009, NIH/CTSA sponsored by VICTR scholarship for proteomic analysis and identification of "SEVI Binding Proteins"
  • 2008, NIGMS/NIH, MARC/FASEB sponsored judges subsidy travel fellowship to the Annual Biomedical Research Conference for Minority Students, Orlando, FL
  • 2008, NIGMS/NIH, MARC/FASEB sponsored predoctoral travel fellowship to the Experimental Biology (EB) Annual Meeting, San Diego, CA