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Address: 115 S. Grand Avenue, 316 PHARIowa City, IA 52242
My primary research interests focused on molecular probe/drug lead
discovery via the high-throughput screening and assay development,
based on my earlier fluorescent and chemo- and bio-sensor expertise,
i.e. fluorescent chemical sensors/nanosensors or label-free high
throughput screening Epic platform. Furthermore, we have reputable
expertise supporting assay design and development (see PubChem).
Through innovative assay development and collaboration with medicinal
chemists, my lab aims to discover novel potent and specific molecular
probes, as well as therapeutic leads for their associated diseases.
The University of Iowa High Throughput Screening Facility (UIHTS) is
a high throughput platform that integrates robotics, detection systems
and chemical /biologics libraries. UIHTS enables scalable screening
approaches, not only to foster hit and lead generation for drug
discovery and development through screening of large chemical/biologics
libraries; but also to facilitate molecular probe discovery for
mechanism of action (MOA) studies of chemical biology through screening
of focused intellectually-designed compound collections. As a
university core facility, UIHTS provides highly flexible screening
services, project management, and assay/technology development for
investigators across campus as well as off-campus. For more information
please visit http://pharmacy.uiowa.edu/high-throughput-screening-facility.
Fen Huang, Hongkang Zhang, Meng Wu, Huanghe
Yang, Makoto Kudo, Christian J. Peters, Prescott G. Woodruff,Owen D.
Solberg, Matthew L. Donne, Xiaozhu Huang, Dean Sheppard, John Fahy,
Paul Wolters, Brigid L. M.Hogan, Walter Finkbeiner, Min Li, Yuh-Nung
Jan, Lily Yeh Jan, Jason R. Rock (2012) TMEM16A-CaCC modulates mucin
secretion and airway smooth muscle contraction, Proceedings of the
National Academy of Sciences of the United States of America ,
Yiu-Yin Cheung, Haibo Yu, Kaiping Xu, Meng Wu,
Owen McManus, Min Li, Craig Lindsley; Corey Hopkins (2012) Discovery of
a Series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel
Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel
Pharmacology: Identification of (S)-2-phenyl-N-(2-
(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant
Kv7.2 Channel Inhibitor, Journal of Medicinal Chemistry.
Haibo Yu, Meng Wu, Steven D. Townsend, Beiyan
Zou, Shunyou Long, J. Scott Daniels, Owen B McManus, Min Li, Craig W.
Lindsley, Corey R. Hopkins (2011) Discovery, Synthesis, and Structure
Activity Relationship of a Series of
N-Aryl-bicyclo[2.2.1]heptane-2-carbox-amides: Characterization of ML213
as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener, ACS Chemical
Hao-Ran Wang, Meng Wu, Haibo Yu, Shunyou Long,
Amy Stevens, Darren W. Engers, Henry Sackin, J. Scott Daniels, Eric S.
Dawson, Corey R. Hopkins, Craig W. Lindsley, Min Li, and Owen B McManus
(2011) Selective inhibition of the Kir2 family of inward rectifier
potassium channels by a small molecule probe: the discovery, SAR and
pharmacological characterization of ML133. ACS CHEMICAL BIOLOGY , 6
Meng Wu, Shunyou Long, Anthony G. Frutos, Maryna
Eichelberger, Min Li, Ye Fang. (2009) Interrogation of
phosphor-specific interaction on a high-throughput label-free optical
biosensor system–Epic® system. Journal of Receptors and Signal
Transduction, 29 (3-4): 202-210.
Maryna C Eichelberger, Arash Hassantoufighi, Meng Wu,
and Min Li. (2008) Neuraminidase activity provides a practical
read-out for a high throughput influenza antiviral screening assay.
Virology Journal, 5:109–117.
Meng Wu, Brian Coblitz, Sojin Shikano, Lisa M.
Cockrell, Haian Fu, Shunyou Long, (2006) SWTY – a general peptide probe
for homogeneous solution binding assay of 14-3-3 proteins. Analytical
Biochemistry, 349(2): 186-196.
Zhihong LIN, Meng WU, Michael Schaeferling, Otto
S. Wolfbeis (2004) Fluorescent Imaging of Citrate and Other
Intermediates in the Citric Acid Cycle. Angew. Chem. Int. Ed.
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