Anatomy and Cell Biology

  • Molecular Medicine and Gene Therapy

    Brad A. Amendt, PhD

    Botand Banfi, MD, PhD

    • Molecular mechanisms that underlying defects in cystic fibrosis and deafness, with a focus on ROS and NADPH oxidase

    Amit Choudhury, MSc, PhD

    • Use of recombinant viral vector(s) to modulate membrane trafficking, with the goal of regulating tumor angiogenesis

    Adam Dupuy, PhD

    • Use of sleeping beauty transposon system to generate tissue specific-models of cancer in mice

    John F. Engelhardt, PhD 

    • Development of gene therapies for inherited and environmentally induced diseases
    • Development of recombinant adeno-associated viral vectors for gene therapy
    • Investigation of the pathogenesis and treatment of cystic fibrosis lung disease
    • Mechanisms underlying ischemia/reperfusion injury and applications of gene therapy in the liver

    C. Andrew Frank, PhD

    • Use of Drosophila genetics and pharmacology to understand signaling pathways that link synaptic instability to disorders of the nervous system

    Nicholas Pantazis, PhD

    • Protection against the neurodegeneration induced by ethanol exposure of the developing brain
    • Development of therapeutic paradigms to ameliorate the brain damage found in fetal alcohol spectrum disorders (FASD)

    Tom Rutkowski, PhD

    • Mechanistic links between endoplasmic reticulum homeostasis and lipid metabolism in the liver
    • Mechanisms whereby dysregulation of the ER stress response contributes to diseases of liver function (metabolic syndrome, hepatitis, alcohol steatosis)

    Charles Yeaman, PhD

    • Molecular mechanisms underlying renal cystogenesis, with a focus on dysfunction of the primary cilia