Siegfried Janz Laboratory—Department of Pathology

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    Contact Information
    Phone: 319-335-9986
    1132 Medical Laboratories

    Our primary research interest concerns mouse models of human B cell and plasma cell neoplasms, such as Burkitt’s lymphoma, Waldenström’s macroglobulinemia and multiple myeloma. Relying in part on gene-insertion mice that mimic the human MYC-activating t(8;14)(q24;q32) translocation, we are recapitulating important features of human B-lineage tumors in single and compound transgenic mice. Mouse models of this sort are then being used to elucidate mechanisms of neoplastic B cell and plasma cell development of great relevance for human beings, and to evaluate new approaches to cancer treatment in patients with lymphoma and myeloma. The long-term goal of our work is to improve the outcome of cancer. To that end, our laboratory maintains close ties with The University of Iowa Holden Comprehensive Cancer Center and the Interdisciplinary Graduate Program in Immunology at the Carver College of Medicine.

    Janz lab
    Left to right: Chunyan Gu, Siggy Janz, Xuefang Jing and Xiaoyan Zhang