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The Potash lab is interested in the DNA sequence and methylation variation that confer susceptibility to depression and bipolar disorder. Family, twin, and adoption studies have made it abundantly clear that these disorders are substantially heritable, but only a very small proportion of that heritability has thus far been explained molecularly. Similarly, the environment clearly plays a role in the etiology of depression, but the molecular basis of that role remains undefined. We are interested in determining the common and rare genetic variants involved in mood disorders risk. We are also investigating DNA methylation variation across the genome, looking for changes induced by stress that might play a role in depression.
James B. Potash, MD, MPH, professional profile
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