Shizhong Han Laboratory

  • DNA helix
  • Publications

    • Shizhong Han, Bao-Zhu Yang, Henry R. Kranzler, Joel Gelernter. Genomewide ordered subset linkage analysis for alcohol dependence in African-Americans. Human Genetics (In Press).
    • Julio E. Molineros, Amit K. Maiti, Celi Sun, Loren L. Looger, Shizhong Han, Xana Kim-Howard , Stuart Glenn, Adam Adler, Jennifer A. Kelly, Timothy B. Niewold, Gary S. Gilkeson, Elizabeth E. Brown, Graciela S. Alarcón, Jeffrey C. Edberg, Michelle Petri, Rosalind Ramsey-Goldman, John D. Reveille, Luis M. Vilá, Barry I. Freedman, Betty P. Tsao, Lindsey A. Criswell, Chaim O. Jacob, Timothy J. Vyse, Carl L. Langefeld, Joel M. Guthridge, Patrick M. Gaffney, Kathy L. Moser, Hal R Scofield, Marta E. Alarcón-Riquelme on behalf of the BIOLUPUS Network, Scott M. Williams, Joan T. Merrill, Judith A. James, Kenneth M. Kaufman, Robert P. Kimberly, John B. Harley, Swapan K. Nath. Admixture Mapping in Systemic Lupus Erythematosus (SLE) Identifies Multiple Common Functional Variants within IFIH1 Associated with Apoptosis, Inflammation and Autoantibody Production. PloS Genetics (In Press).
    • Jian Cao, Xiangtao Liu, Shizhong Han, Clarence K. Zhang, Zongzhi Liu, Dawei Li. Association of the HTR2A Gene with Alcohol and Heroin Abuse. Human Genetics (In Press).
    • Shizhong Han, Bao-Zhu Yang, Henry R. Kranzler, David Oslin, Raymond Anton, Lindsay A. Farrer, Joel Gelernter. Linkage analysis followed by association show NRG1 associated with cannabis dependence in African-Americans. Biological Psychiatry 2012 Oct 15;72(8):637-44.
    • Hartz, SM, S Short, NL Saccone, R Culverhouse, LS Chen, T Schwantes-An, H Coon, Y Han, SH Stephens, J Sun, X Chen, F Ducci, N Dueker, N Franceschini, J Frank, F Geller, D Guðbjartsson, N Hansel, C Jiang, K Keskitalo-Vuokko, J Liu, L Lyytikäinen, M Michel, R Rawal, A Rosenberger, P Scheet, JR Shaffer, A Teumer, JR Thompson, JM Vink, N Vogelzangs, A Wenzlaff, W Wheeler, X Xiangjun , BZ Yang, SH Aggen, A Balmforth, S Baumeister, T Beaty, S Bennett, A Bergen, H Boyd, U Broms, H Campbell, N Chatterjee, J Chen, YC Cheng, S Cichon, D Couper, F Cucca, D Dick, T Foroud, H Furberg, I Giegling, F Gu, A S Hall, J Hällfors, S Han, AM Hartmann, C Hayward, K Heikkilä, JK Hewitt, JJ Hottenga, M Jensen, P Jousilahti, M Kaakinen, S Kittner, B Konte, T Korhonen, MT Landi, T Laatikainen, M Leppert, SM Levy, R Mathias, DW McNeil, S Medland, G Montgomery, T Muley, T Murray, M Nauck, K North, M Pergadia, O Polasek, E Ramos, S Ripatti, A Risch, I Ruczinski, I Rudan, V Salomaa, D Schlessinger, U Styrkársdóttir, A Terracciano, M Uda, G Willemsen, X Wu, G Abecasis, K Barnes, H Bickeböller, E Boerwinkle, DI Boomsma, N Caporaso, J Duan, HJ Edenberg, C Francks, PV Gejman, J Gelernter, HJ Grabe, H Hops, MR Jarvelin, V Jorma, M Kähönen, KS Kendler, T Lehtimäki, DF Levinson, ML Marazita, J Marchini, M Melbye, B Mitchell, JC Murray, MM Nöthen, BW Penninx, O Raitakari, M Rietschel, D Rujescu, N J Samani , AR Sanders, A Schwartz, S Shete, J Shi, M Spitz, K Stefansson, G Swan, T Thorgeirsson, H Völzke, Q Wei, HE Wichmann, C Amos, N Breslau, D Cannon, M Ehringer, R Grucza, D Hatsukami, A Heath, E Johnson, J Kaprio, P Madden, NG Martin, V Stevens, JA Stitzel, RB Weiss, P Kraft, LJ Bierut. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers'. Archives of General Psychiatry 2012 Aug;69(8):854-60.
    • Bao-Zhu Yang, Shizhong Han, Henry R. Kranzler, Lindsay A. Farrer, Robert C. Elston, Joel Gelernter. Genomewide Linkage Scan for Loci Predisposing to Comorbid Dependence on Multiple Substances. Am J Med Genet B Neuropsychiatr Genet 2012 Jun;159B(4):361-9.
    • Bao-Zhu Yang, Shizhong Han, Henry R. Kranzler, Lindsay A. Farrer, Joel Gelernter. A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in two populations. Neuropsychopharmacology 2011 Nov;36(12):2422-30.
    • Shizhong Han, Bao-Zhu Yang, Henry R. Kranzler, David Oslin, Raymond Anton, Joel Gelernter. Association of CHRNA4 polymorphisms with smoking behavior in two populations. Am J Med Genet B Neuropsychiatr Genet 2011 Jun;156B(4):421-9.
    • Li Ma, Shizhong Han*, Jing Yang, Yang Da. Multi-locus test conditional on confirmed effects leads to increased power in genome-wide association studies. PLoS One 2010 Nov 16;5(11):e15006. (*Joint first author).
    • Nancy L. Saccone, Robert C. Culverhouse, Tae-Hwi Schwantes-An, Dale S. Cannon, Xiangning Chen, Sven Cichon, Ina Giegling, Shizhong Han, Younghun Han, Kaisu Keskitalo-Vuokko, Xiangyang Kong, Maria Teresa Landi, Jennie Z. Ma, Susan E. Short, Sarah H. Stephens, Victoria L. Stevens, Lingwei Sun, Yufei Wang, Angela S. Wenzlaff, Steven H. Aggen, Naomi Breslau, Peter Broderick, Nilanjan Chatterjee, Jingchun Chen, Andrew C. Heath, Markku Heliövaara, Nicole R. Hoft, David J. Hunter, Majken K. Jensen, Nicholas G. Martin, Grant W. Montgomery, Tianhua Niu, Thomas J. Payne, Leena Peltonen, Michele L. Pergadia, John P. Rice, Richard Sherva, Margaret R. Spitz, Juzhong Sun, Jen C. Wang, Robert B. Weiss, William Wheeler, Stephanie H. Witt, Bao-Zhu Yang, Neil E. Caporaso, Marissa A. Ehringer, Tim Eisen, Susan M. Gapstur, Joel Gelernter, Richard Houlston, Jaakko Kaprio, Kenneth S. Kendler, Peter Kraft, Mark F. Leppert, Ming D. Li, Pamela A. F. Madden, Markus M. Nöthen, Sreekumar Pillai, Marcella Rietschel, Dan Rujescu, Ann Schwartz, Christopher I. Amos, Laura J. Bierut. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PloS Genetics 2010 6(8). pii: e1001053.
    • Shizhong Han, Joel Gelernter, Xingguang Luo, Bao-Zhu Yang. Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biological Psychiatry 2010 Jan 1;67(1):12-9.
    • Shizhong Han, Li Ma, Dawei Li, Bao-Zhu Yang. Is the tail strength measure more powerful in tests of genetic association? American Journal of Human Genetics 2009 Feb;84(2):295-8.
    • Shizhong Han, Xana Kim-Howard, Harshal Deshmukh, Yoichiro Kamatani, Parvathi Viswanathan, Joel M. Guthridge, Kenaz Thomas, Kenneth M. Kaufman, Joshua Ojwang, Adriana Rojas-Villarraga, Vicente Baca, Lorena Orozco, Benjamin Rhodes, Chan-Bum Choi, Peter K. Gregersen, Joan T. Merril, Judith A. James, Patrick M. Gaffney, Kathy L. Moser, Chaim O. Jacob, Robert P. Kimberly, John B. Harley, Sang-Choel Bae, Juan-Manuel Anaya, Marta E. Alarcón-Riquelme, Koichi Matsuda, Timothy J. Vyse and Swapan K. Nath. Evaluation of Imputation-based Association in and around the Integrin-α-M (ITGAM) gene and Replication of Robust Association between a Non-synonymous Functional variant within ITGAM and Systemic lupus erythematosus (SLE). Human Molecular Genetics 2009 Mar 15;18(6):1171-80.
    • Swapan K Nath, Shizhong Han, Xana Kim-Howard , Jennifer A Kelly, Parvathi Viswanathan, Gary S Gilkeson, Wei Chen, Cheng Zhu, Rodger P McEver, Robert P Kimberly, Marta E Alarcón-Riquelme, Timothy J Vyse, Quan-Zhen Li, Edward K Wakeland, Joan T Merrill, Judith A James, Kenneth M Kaufman, Joel M Guthridge & John B Harley. A nonsynonymous functional variant in integrin-aM (encoded by ITGAM) is associated with systemic lupus erythematosus. Nature Genetics 2008 Feb;40(2):152-4.
    • Shizhong Han, Joel M. Guthridge, Isaac T. W. Harley, Andrea L. Sestak, Xana Kim-Howard, Kenneth M. Kaufman , Bahram Namjou, Harshal Deshmukh, Gail Bruner, Luis R. Espinoza, Gary S. Gilkeson, John B. Harley, Judith A. James, Swapan K. Nath. Osteopontin and Systemic Lupus Erythematosus Association: A Probable Gene-Gender Interaction. PLoS one 2008 3(3):e001757.
    • Dharambir K Sanghera, Lyda Ortega, Shizhong Han, Jairup Singh, Sarju K Ralhan, Gurpreet S Wander, Narinder K Mehra, John J Mulvihill, Robert E Ferrel, Swapan K Nath and Mohammed I Kamboh. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 2008 Jul 3;9:59.
    • Amr H. Sawalha, Ryan Webb, Shizhong Han, Jennifer A. Kelly, Kenneth M. Kaufman, Robert P. Kimberly, Marta E. Alarcón-Riquelme, Judith A. James, Timothy J. Vyse, Gary S. Gilkeson, Chan-Bum Choi, R. Hal Scofield, Sang-Cheol Bae, Swapan K. Nath, John B. Harley. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS one 2008 3(3):e1727.
    • Yan Huang, Shizhong Han, Yao Li, Yumin Mao and Yi Xie. Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis. Journal of Human Genetics 2007;52(1):73-85.
    • Shizhong Han, Hong-Tao Zhang, Zhentian Wang, Yi Xie, Rong Tang, Yumin Mao, Yao Li. DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies. European Journal of Human Genetics 2006 Oct;14(10):1136-44.
    • Shizhong Han, Suhua Zhang, Rong Li, Wenyu Zhang, Yao Li, Zhentian Wang, Yi Xie, Yumin Mao. CTLA4 polymorphisms and ophthalmopathy in Graves’ disease patients: association study and meta-analysis. Human Immunology 2006 Aug;67(8):618-26.
    • Shizhong Han, Suhua Zhang, Rong Li, Yao Li. The common -318C/T polymorphism in the promoter region of CTLA4 gene is associated with reduced risk of ophthalmopathy in Chinese Graves’ patients. International Journal of Immunogenetics 2006 Aug;33(4):281-7.
    • Shizhong Han, Yao Li, Yumin Mao and Yi Xie. Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis. Human Genetics 2005 Oct;118(1):123-32.