Kathryn G. Lamping, Ph.D.

Kathryn G. Lamping, Ph.D.
Associate Professor
Ph.D. (pharmacology)
Milwaukee Medical, 1983
E-mail: kathryn-lamping@uiowa.edu
Office: 6W-29 VA
Phone: (319) 339-7019

Regulation of Coronary Microcirculation

The goal of the research in my laboratory is to further our understanding of the mechanisms involved in gender differences in vascular reactivity under normal conditions and diabetes. We have demonstrated that estrogen modulates contractility of the vasculature through regulation of calcium sensitivity of contractile proteins in smooth muscle. The ability of estrogen to modulate calcium sensitivity is mediated through the Rho/rho-kinase pathway. Estrogen modulates this pathway in diabetics as well to protect vasculature in female animals. We are currently focusing on the mechanisms responsible for estrogen regulation of the Rho/rho-kinase pathway. In addition, we are examining mechanisms responsible for the dysregulation in both Type 1 and Type 2 diabetics. Diabetes is a major risk factor for development of cardiovascular disease. Understanding mechanisms that contribute to vascular dysfunction in diabetes may provide clues for treatment to prevent the progression of cardiovascular disease.

Representative Publications:

Pierce, S.L., Kresowik, J.D., Lamping, K.G., and England, S.K.: Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice. Biol Repro 78:1058-1063, 2008.

Nuno, D., Korovkina, V., England, S., and Lamping, K.G.: RhoA activation contributes to sex differences in vascular contractions. Arterioscler Thromb Vasc Biol 27:1934-1940, 2007.

Lamping, K.G.: Endothelial progenitor cells. Sowing the seeds for vascular repair. Editorial, Circ Res 100:1243-1245, 2007.

Zhou, W., Wang, X.L., Lamping, K.G., Lee, H.C.: Inhibition of PKC beta protects against diabetes-induced impairment in arachidonic acid dilation of small coronary arteries. J Pharmacol Expt Therap. 319:199-207, 2006.

Click here to see a list of additional publications

Center and Program affiliations:

The Cardiovascular Center

Biosciences Program


	Kathryn G. Lamping, Ph.D. Associate Professor Ph.D. (pharmacology) Milwaukee Medical, 1983 E-mail: kathryn-lamping@uiowa.edu Office: 6W-29 VA Phone: (319) 339-7019
Regulation of Coronary Microcirculation
The goal of the research in my laboratory is to further our understanding of the mechanisms involved in gender differences in vascular reactivity under normal conditions and diabetes. We have demonstrated that estrogen modulates contractility of the vasculature through regulation of calcium sensitivity of contractile proteins in smooth muscle. The ability of estrogen to modulate calcium sensitivity is mediated through the Rho/rho-kinase pathway. Estrogen modulates this pathway in diabetics as well to protect vasculature in female animals. We are currently focusing on the mechanisms responsible for estrogen regulation of the Rho/rho-kinase pathway. In addition, we are examining mechanisms responsible for the dysregulation in both Type 1 and Type 2 diabetics. Diabetes is a major risk factor for development of cardiovascular disease. Understanding mechanisms that contribute to vascular dysfunction in diabetes may provide clues for treatment to prevent the progression of cardiovascular disease. Representative Publications: Pierce, S.L., Kresowik, J.D., Lamping, K.G., and England, S.K.: Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice. Biol Repro 78:1058-1063, 2008. Nuno, D., Korovkina, V., England, S., and Lamping, K.G.: RhoA activation contributes to sex differences in vascular contractions. Arterioscler Thromb Vasc Biol 27:1934-1940, 2007. Lamping, K.G.: Endothelial progenitor cells. Sowing the seeds for vascular repair. Editorial, Circ Res 100:1243-1245, 2007. Zhou, W., Wang, X.L., Lamping, K.G., Lee, H.C.: Inhibition of PKC beta protects against diabetes-induced impairment in arachidonic acid dilation of small coronary arteries. J Pharmacol Expt Therap. 319:199-207, 2006. Click here to see a list of additional publications Center and Program affiliations: The Cardiovascular Center Biosciences Program