Lecture Schedule
71:182
Neurotransmitter Receptors and Ion Channels
Spring Semester, 2008

Course Directors:
       C.F. Wu, Ph.D.
           335-1091
              and
       J.W. Hell,Ph.D.
           384-4732

Lectures:
      1:30 - 3:20 PM, Mon; 1:30 - 2:20 PM, Wed
      Block I and II (102 BSL); Block II (2-322 BSB)

Discussions:
      2:30 - 3:20 PM, Wed
      102 BSL

Date

Topic

Instructor

1/23

Introduction: Aspects of Neurophysiology & Cell & Molecular Biology of the Neuron

J.W. Hell (102 BSL)

 

Block I: Cellular Electrophysiology

C. F. Wu

1/28

Resting Potential I: Functional Significance; Thermodynamic Aspects

C. F. Wu (BSL)

1/30

Resting Potential II: Experimental Manipulations - Discussion

C.F. Wu (BSL)

2/4

Propagation of Electric Signals

C.F. Wu (BSL)

2/6

Passive Properties I: Functional Implications - Discussion

C.F. Wu (BSL)

2/11

Passive Properties II: Modeling and Analysis

C.F. Wu (BSL)

2/13

Voltage Clamp I: Ionic Theory; I-V Characteristics; Separation of Currents - Discussion

C.F. Wu (BSL)

2/18

Voltage Clamp II: Relaxation; Inactivation

C.F. Wu (BSL)

2/20

Neuronal Model: H-H equations
Disscussion

C.F. Wu (BSL)

2/25

End-plate Potential I: Ca2+ Theory and Properties of Neuromuscular Transmission

C.F. Wu (BSL)

2/27

EXAM I

 

3/3

End-plate Potential II: Ionic Basis & Quantal Events

C.F. Wu (BSL)

Block II: Molecular and Cell Biological Aspects of Ion Channels and Receptors

J.W. Hell

3/5

Na Channels: General Structure, Activation/Inactivation

J.W. Hell (BSB)

3/10

K Channels I: Overview and Shaker Type K Channels

S. England (BSB)

3/12

K Channels II: Structure - Function

J.W. Hell (BSB)

3/17 & 19

Spring Break

3/24

Ca Channels I: General Structure, Classification Pharmacology; etc.

J.W. Hell (BSB)

3/26

Ca Channels II: Neurotransmitter Release

J. W. Hell (BSB)

3/31

Glutamate Receptors I: Structure Function

J. W. Hell (BSB)

4/2

ACh Receptors

T. Kitamoto (BSB)

4/7

GABA and Glycine Receptors

D. Hammond (BSB)

4/9

Glutamate Receptors II: Cell Biology, LTP, Stroke

J. W. Hell (BSB)

4/14

TRP Channels
Acid-sensitive Ion Channels

Y. Usachev (BSB)
C. Benson (BSB)

4/16

EXAM II

 

 

Block III: Neural Circuits and System Physiology

C.F. Wu (BSL)

4/21

Integrative Organization of Neurons - Discussion

C.F. Wu (BSL)

4/23

Reflexes and Fixed Action Patterns

C.F. Wu (BSL)

4/28

Auditory System

P. Abbas) (BSL)

4/30

Visual System - Presentations

C.F. Wu (BSL)

5/5

Cortical Plasticity

Inah Lee (BSL)

5/7

Learning and Memory - Presentations

C.F. Wu (BSL)

5/12

FINAL EXAM