Pharmacology

  • Ion Channels

    071:138
    Spring Semester, 2013

    Course Director

    Durga (DP) Mohapatra, PhD
    Phone: (319) 335-6944

    Teaching Assistant

    Mr. Xiaomin Xing
    Biology graduate student
    Office Hours: 3:00 - 5:00 Monday and Wednesday or by appointment

    Lectures

    2/25/13 - 4/3/13
    Monday (1:30 - 3:20 pm); Wednesday (1:30 - 2:20 pm)
    3189 ML

    Course Schedule

    Date Lecturer Topic
    Feb 25 Mohapatra Introduction to Ion Channels
    Classification (voltage- & ligand-gated), expression and tissue distribution, basic principles for the study of ion channels, overivew of ion channel pharmacology
    Feb 27 Mohapatra Potassium (K+) Channels I
    Classification, distribution & localization, regulation of membrane excitability, and K+ channel pharmacology
    Mar 4 Ahern Sodium (Na+) Channels
    Classification, distribution & localization, ion selectivity, conduction & activation/inactivation gating, and regulation of excitability
    Mar 6
    2114 ML    		 Mohapatra Potassium (K+) Channels II
    Ion selectivity, conduction, and structure-function aspects of activation / inactivation gating
    Mar 11 Lee Calcium (Ca2+) Channels I
    Classification, distribution & localization, ion selectivity, overview of activation / inactivation, and regulation of neurotransmitter release
    Mar 13 Lee Calcium (Ca2+) Channels II
    Calcium channel modulations
    Mar 18-22 Spring Break
    Mar 25 Mohapatra TRP Channels
    Classification, distribution & localization, overview of activation / inactivation gating, and role in membrane excitability
    Mar 27 Benson ASIC Channels
    Classification, distribution & localization, structure-function aspects of activation / inactivation gating, and role in membrane excitability
    Apr 1 Paper Presentation & Discussion
    Apr 4 Discussion (5:30 - 7:50p) Aud 3 BSB
    Apr 3 Lueck Chloride (CL-) Channels
    Classification, distribution & localization, ion selectivity, overview of activation / inactivation gaing, and role in membrane excitability
    April 11 Final Exam (5:30 - 8:20p) Aud 3 BSB

    NOTE: This course also serves as the Block II Neurophysiology (132:181 / 002:181 / 071:138) for Neuroscience and Biology Graduate students and Undergraduate Biology students with Neurobiology major, due to which additional 12-16 students will attend this module.