• Ion Channel Pharmacology

    PCOL:6207 (071:138)
    Spring Semester, 2014

    Course Director

    Durga (DP) Mohapatra, PhD
    Phone: (319) 335-6944

    Teaching Assistant

    Mr. Francis Jareczek
    Neuroscience / PSTP graduate student
    Office Hours: 3:00 - 5:00 Monday and Wednesday or by appointment


    2/24/14 - 4/2/14
    Monday (1:30 - 2:50 pm); Wednesday (1:30 - 2:50 pm)
    2-224 BSB

    Course Schedule

    Date Lecturer Topic
    Feb 24 Mohapatra Introduction to Ion Channels
    Classification (voltage- & ligand-gated), expression and tissue distribution, basic principles and experimental techniques for the study of ion channels  
    Feb 26 Mohapatra Neuronal Voltage-gated Cation Channels I
    Neural expression/distribution, and sub-cellular localization of voltage-gated Na+, K+, Ca2+ and HCN channels
    Mar 3 Ahern Neuronal Voltage-gated Cation Channels II
    Principles of ion selectivity, conduction & activation/inactivation gating of voltage-gated Na+, K+ and Ca2+ channels
    Mar 5 Lueck / Robertson Neuronal Anion Channels
    Neural expression/distribution, sub-cellular localization, ion selectivity, conduction, and activation/inactivation gating of voltage- and ligand-gated Cl- channels
    Mar 10 Mohapatra / Benson Neuronal Ligand-gated Non-selective Cation Channels
    Neural expression/ distribution, sub-cellular localization, ion conduction/gating of TRP/ASIC/CNG channels
    Mar 12 Ahern Voltage-gated Cation Channels in Muscles and Cardiovascular System
    Cardiovascular/muscle tissue expression/distribution and sub-cellular localization of voltage-gated Na+, K+, Ca2+ and HCN channels, their role in muscle excitability, and excitation-contraction coupling
    Mar 17-19 Spring Break
    Mar 24 Lueck Anion Channels in Muscles and Cardiovascular System
    Expression/distribution, ion selectivity, overview of activation/inactivation gating voltage- and ligand-gated Cl- channels, and regulation of muscle excitability
    Mar 26 Benson Drugs Targeting Muscle/Cardiovascular Ion Channels
    Overview of diseases/ pathologies of muscular and cardiovascular systems that are caused by defects in ion channel expression/function, and mechanisms of action of drugs that target these ion channels
    Mar 31 Discussion / Paper Presentation
    Apr 2 Mohapatra Drugs Targeting Neuronal Ion Channels
    Overview of diseases/pathologies of the nervous system caused by defects in ion channel expression/function and mechanisms of action of drugs that target neuronal ion channels
    Current Developments in Ion Channel Drug Targeting
    Recent reports on ongoing drug development programs by pharmaceuticals, and future strategies and challenges in drug development targeting ion channels


    April 4 Final Exam - TBD

    NOTE: This course also serves as the Block II Neurophysiology (132:181 / 002:181 / 071:138) for Neuroscience, Biology Psychology and Applied Mathematics graduate students