Faculty
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PETER L. NAGY, M.D., Ph.D.
Assistant Professor, Molecular Pathology
Director, Molecular Genetic Testing
354 Medical Research Center
Iowa City, IA 52242-1182
M.D. University of Pecs Faculty of Medicine, Hungary, 1989
Ph.D. in Biochemistry, Purdue University, 1995
Anatomic Pathology Resident, Stanford University Medical Center, 1995-1997
Chief Resident, Autopsy Pathology Fellow, Stanford University Medical Center, 1998
Postdoctoral Fellow, Stanford University Medical Center, 1998-2003
Fellow, Molecular Genetic Pathology, Stanford University Medical Center, 2003-2004 |
My clinical responsibility is development and evaluation of molecular tests relating to oncology. My laboratory does work in three main areas.
- We use the tools of biochemistry and genetics to understand how histone methyltransferases are regulated and targeted.
- We are mapping the contribution of individual histone methyltransferases to the differentiation of hematopoietic cell lineages.
- We screen tumor samples for mutations in histone methyltransferases to extend our understanding of the role of these enzymes in human malignancies.
Selected publications:
1. Nagy PL, Griesenbeck J, Kornberg RD, Cleary ML. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc. Natl. Acad. Sci. USA. 99(1): 90-4. 2002.
2. Nagy PL, Cleary ML, Brown PO, Lieb JD. Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin. Proc. Natl. Acad. Sci. USA. 100(11): 6364-9. 2003
3. Nagy PL, Marolewsky A, Benkovic S, Zalkin H. Formyltetrahydrofolate Hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. J. Bacteriol. 177:1292-98. 1995.
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