peter-nagy@uiowa.edu Voice: 319-353-4594

PETER L. NAGY, M.D., Ph.D. Assistant Professor, Molecular Pathology Director, Molecular Genetic Testing 354 Medical Research Center Iowa City, IA 52242-1182 M.D. University of Pecs Faculty of Medicine, Hungary, 1989 Ph.D. in Biochemistry, Purdue University, 1995 Anatomic Pathology Resident, Stanford University Medical Center, 1995-1997 Chief Resident, Autopsy Pathology Fellow, Stanford University Medical Center, 1998 Postdoctoral Fellow, Stanford University Medical Center, 1998-2003 Fellow, Molecular Genetic Pathology, Stanford University Medical Center, 2003-2004

My clinical responsibility is development and evaluation of molecular tests relating to oncology.   My  laboratory does work in three main areas.

1. We use the tools of biochemistry and genetics to understand how histone methyltransferases are regulated and targeted.
2. We are mapping the contribution of individual histone methyltransferases to the differentiation of hematopoietic cell lineages.
3. We screen tumor samples for mutations in histone methyltransferases to extend our understanding of the role of these enzymes in human malignancies.

Selected publications:

1. Nagy PL, Griesenbeck J, Kornberg RD, Cleary ML. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc. Natl. Acad. Sci. USA. 99(1): 90-4. 2002.

2. Nagy PL, Cleary ML, Brown PO, Lieb JD. Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin. Proc. Natl. Acad. Sci. USA.  100(11): 6364-9. 2003

3. Nagy PL, Marolewsky A, Benkovic S, Zalkin H. Formyltetrahydrofolate Hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. J. Bacteriol. 177:1292-98. 1995.