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Research: Dr. Meyerholz is a veterinary pathologist with a major interest in pulmonary pathology, immunity and disease. His research involves examination, detection and interpretation of cellular changes associated with cystic fibrosis, RSV, influenza, SARS-CoV and other pulmonary diseases. His lab specializes in anatomic phenotyping of new CF models (e.g. pig, ferret) and in developing novel morphologic techniques for the detection of cellular disease markers in the lung. In addition, his lab investigates regulation of inflammatory mediators in acute model of pancreatis model, phenotypic characterization of novel oncogenes, and immunopathology associated with chronic ethanol ingestion. Dr. Meyerholz directs the Comparative Pathology Laboratory (CPL), which provides UI Investigators with scientific support including necropsy, gross and microscopic examination/interpretation, comprehensive anatomic phenotyping, histology services and scientific consultation. Interests: Atherosclerosis, Bone healing, Cancer pathobiology, Comparative pathology, Cystic fibrosis, Developmental disease, Ethanol-associated immunopathology, Models of human disease, Pancreatitis, Pulmonary pathology, Viral pathogenesis (e.g. Influenza, RSV, SARS-CoV, etc.) Selected Publications: Castilow, EM, Meyerholz DK, Varga SM. IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease. Journal of Immunology. 180:2376-2384, 2008. Castilow, EM, Olson MR, Meyerholz DK, Varga SM. IFN-g modulates vaccine-enhanced disease mediated by RSV F protein-specific CD4 T cells. Journal of Virology. 82:2196-2207, 2008. George CL, Goss KL, Meyerholz DK, Lamb FS, Snyder JM. Surfactant associated protein-A provides critical immunoprotection in neonatal mice. Infection and Immunity, 76:380-390, 2008. Meyerholz DK, Samuel I. Morphologic characterization of early ligation-induced acute pancreatitis in rats. American Journal of Surgery. 194:652-658. 2007. Itoh T, Iwashita S, Cohen MB, Meyerholz DK, Linn S. Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis. Human Molecular Genetics, 216:1578-1586, 2007. McCray PB Jr, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S: Lethal infection in K18-hACE2 mice infected with SARS-CoV. Journal of Virology, 81:813-21, 2007. (See complete publications list at PubMed) |
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