Faculty
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MATTHEW D. KRASOWSKI, M.D., Ph.D. Assistant Professor Laboratory Director, Clinical Chemistry 200 Hawkins Drive - 6233 Roy Carver Pavilion Iowa City, IA 52242-1009 Ph.D. University of Chicago, 1999 M.D. University of Chicago, 2001 Pathology Residency, University of Chicago, 2001-2004 Clinical Pharmacology & Pharmacogenomics Fellowship, University of Chicago, 2003-2005 |
As the Director of the Clinical Chemistry Laboratory, I am interested in all aspects of diagnostic chemistry, including cardiac markers, endocrinology, therapeutic drug monitoring, and toxicology. I have used computational methods to predict cross-reactivity of immunoassays used in clinical chemistry, especially those used for drug of abuse screening and therapeutic drug monitoring. My basic research interests include drug metabolism, molecular toxicology, and bile acids, as well as the structure and evolution of nuclear hormone receptors. In terms of educational activities, I am director of the two-week medical school clerkship on laboratory medicine and am interested in developing novel methods of teaching laboratory medicine to medical students and residents.
Selected publications:
Krasowski MD, Siam MG, Iyer M, Pizon AF, Giannoutsos S, Ekins S. Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays. Clin Chem 55(6): 1203-1213, 2009. [PMID: 19342505]
Krasowski MD, Siam MG, Iyer M, Ekins S. Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassays. Ther Drug Monit 31(3): 337-344, 2009. [PMID: 19333148]
Krasowski MD, Pizon AF, Siam MG, Giannoutsos S, Iyer M, Ekins S. Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine. BMC Emerg Med 9: 5, 2009. [PMID: 19400959]
Ai N, Krasowski MD, Welsh WJ, Ekins S. Understanding nuclear receptors using computational methods. Drug Discov Today 14(9-10): 486-494, 2009. [PMID: 19429508]
Kortagere S, Krasowski MD, Ekins S. The importance of discerning shape in molecular pharmacology. Trends Pharmacol Sci 30(3): 138-147, 2009. [PMID: 19187977]
Pizon AF, Schwartz AR, Shum LR, Rittenberger JC, Lower DR, Giannoutsos S, Virji MA, Krasowski MD. Clin Toxicol (Phila) 47(2): 132-136, 2009. [PMID: 18608262]
Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann AF, Krasowski MD. Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res 49(7): 1577-1587, 2008. [PMID: 18362391]
Genzen JR, Krasowski MD. Resident training in clinical chemistry. Clin Lab Med 27(2): 343-358, 2007. [PMID: 17556088]
Krasowski MD, Yasuda K, Hagey LR, Schuetz EG. Evolution of the pregnane X receptor: adaptation to cross-species differences in biliary bile salts. Mol Endocrinol 19(7): 1720-1739. [PMID: 15718292]