Home Faculty |
Faculty
Siegfried Janz’ primary research interest concerns mouse models of human B cell and plasma cell neoplasms that are induced by the deregulated expression of the cellular oncogene MYC (c-myc). His laboratory has recently generated gene-insertion mice that mimic three different states of the human MYC-activating t(8;14)(q24;q32) translocation. He is now developing genetic methods for the detection of the homologous Myc-activating T(12;15) translocation in mice. As co-leader of the program on Cancer Genetics and Computational Biology, Siegfried Janz is also actively engaged in the research effort of the Holden Comprehensive Cancer Center at the Roy J. and Lucille A. Carver College of Medicine at The University of Iowa Hospitals and Clinics. His primary goal here is to enhance our understanding of the molecular genetics for a wide range of malignancies, including solid tumors, and to apply this knowledge for an improved therapeutic outcome of cancer and successful cancer prevention. |
||
