Faculty

toshiki-itoh@uiowa.edu Voice: 319-353-4235

TOSHIKI ITOH M.D., Ph.D. Assistant Professor Pathology - 1169 Medical Laboratories Iowa City, IA 52242-1181 M.D. Kumamoto University School of Medicine, Japan, 1989 Dermatology Residency, Kumamoto University School of Medicine, Japan, 1989-1991 Ph.D. Graduate School of Medicine, Kumamoto University School of Medicine, Japan, 1996 Research Associate, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan, 1996-1999 Visiting Assistant Researcher, University of California, Berkeley, 1999-2002 Assistant Researcher, University of California, Berkeley, 2002-2005

Selected Publications:

1. D. Bennett, and T. Itoh. The XPE gene of xeroderma pigmentosum, its product and biological roles. In: Molecular Mechanisms of Xeroderma Pigmentosum. Chapter 7, Eurekah in press.

2. T. Itoh, S. Iwashita, M.B. Cohen, D.K. Meyerholz, and S. Linn. 2007. Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis. Human Molecular Genetics 16: 1578-1586.

3. T. Itoh. 2006. Xeroderma pigmentosum group E and DDB2, a smaller subunit of damage-specific DNA binding protein: proposed classification of xeroderma pigmentosum, Cockayne syndrome, and ultraviolet-sensitive syndrome. Journal of Dermatological Sciences 41: 87-96.

4. T. Itoh, and S. Linn. 2005.  The fate of p21^CDKN1A in cells surviving UV-irradiation. DNA repair  4: 1457-1462.

5. T. Itoh, D. Cado, R. Kamide, and S. Linn. 2004.  DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen.  Proceedings of the National Academy of Sciences U.S.A. 101: 2052-2057 (Track II).

6. T. Itoh, C. O’shea, and S. Linn.  2003.  Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48^DDB2 and p53.   Molecular and Cellular Biology 23: 7540-7553.

7. A.F. Nichols, T. Itoh, F. Zolezzi, S. Hutsell, and S. Linn.  2003.  Basal transcriptional regulation of human damage-specific DNA binding protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements.  Nucleic Acids Research 31: 562-569.

8. G. Spivak, T. Itoh, T. Matsunaga, O. Nikaido, P. Hanawalt, and M. Yamaizumi.  2002.  Ultraviolet-sensitive Syndrome Cells are Defective in Transcription-coupled Repair of Cyclobutane Pyrimidine Dimers.  DNA Repair 1: 629-643.

9. T. Itoh, and S. Linn.  2001.  XP43TO, Previously Classified as Xeroderma Pigmentosum Group E, Should Be Reclassified as Xeroderma Pigmentosum Variant. Journal of Investigative Dermatology 117: 1672-1674.

10. T. Itoh, A.F. Nichols, and S. Linn. 2001.  Abnormal Regulation of DDB2 Gene Expression in Xeroderma Pigmentosum Group E Strains.  Oncogene 20: 7041-7050.

11. T. Itoh, S. Linn, R. Kamide, H. Tokushige, N. Katori, H. Hosaka, and M. Yamaizumi.  2000.  Xeroderma Pigmentosum Variant Heterozygotes Show Reduced Levels of Recovery of Replicative DNA Synthesis in the Presence of Caffeine after Ultraviolet Irradiation.  Journal of Investigative Dermatology 115: 981-985.

12. A.F. Nichols, T. Itoh, J.A. Graham, W. Liu, M. Yamaizumi, and S. Linn. 2000. Human damage-specific DNA binding protein p48: characterization of XPE mutations and regulation following UV-irradiation. Journal of Biological Chemistry 275: 21422-21428.

13. Itoh, S. Linn, T. Ono, and M. Yamaizumi. 2000.  Reinvestigation of the classification of five cell strains of xeroderma pigmentosum group E with reclassification of three of them. Journal of Investigative Dermatology 114: 1022-1029.

14. T. Itoh, and M. Yamaizumi. 2000.  UV^s syndrome: establishment and characterization  of fibroblastic cell lines transformed with Simian virus 40 DNA. Journal of Investigative Dermatology 114: 101-106.

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