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My interests are in the immunology of alcoholism, including basic processes such as lymphocyte activation and adhesion, emigration, neutrophil and monocyte adhesion, and cytokine-mediated lymphocyte differentiation. We utilize clinical material from alcoholic patients and from experimental murine models of alcoholism, and evaluate the above parameters by flow cytometry, cell culture, and standard functional measures. Current results show that alcoholics have major shifts in cell activation and differentiation markers, some of which are reversible after withdrawal. The general results of these studies are of interest in understanding mechanisms both of immunodeficiency, and of autoimmunity leading to tissue damage such as alcoholic hepatitis. |
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