Pathology

  • Active Grant Awards

    Dr. Siegfried Janz received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is Validation of FOXM1 as a New Therapeutic Target in High-risk Myeloma. The total funding for this award is $364,857 and the project period is July 18, 2016 through June 30, 2018.

    Dr. Weizhou Zhang received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is CD177 Suppresses Breast-cancer Development by Inhibiting Beta-catenin. The total funding for this award is $1,744,220 and the project period is July 1, 2016 through June 30, 2021.

    Dr. Fred Dee received grant funding from the Edward J. Stemmler MD Medical Education Research Fund (National Board of Medical Examiners). Dr. Dee is co-principal investigator on the project with Dr. Kristi Ferguson, Director of OCRME. The title of the project is Validation of a Case Diagramming Tool to Assess Higher-Order Thinking Skills. The total funding for the grant is $148,000 and the project period is July 2016 through July 2018.

    Dr. Nitin Karandikar received grant funding from the National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Immune Dysregulation During Multiple Sclerosis Relapse. The total funding for this award is $3,661,055 and the project period is May 19, 2016 through April 30, 2021.

    Dr. Kevin Legge received grant funding from the National Institutes of Health/National Institute of Alcohol Abuse and Alcoholism (NIH/NIAAA). The title of this project is Chronic Alcohol Alteration of Influenza-Specific CD8 T Cell Immunity and Protection. This funding total is $397,699 and is for the period of May 5, 2016 and should be complete by April 30, 2018.

    Dr. Siegfried Janz was selected to receive an American Society of Hematology (ASH) Bridge Grant Award. The award amount is $150,000 and covers the period of March 1, 2016 through February 28, 2017.

    Dr. Siegfried Janz has a new research contract negotiated with Pharmacyclics, Inc. for a research project titled Co-Clinical Trial of Ibrutinib in a Genetically Engineered Mouse Model of Human Multiple Myeloma. This contract total is $67,768 and the project began February 25, 2016 and should be completed by February 17, 2017.

    Dr. Chen Zhao received an American Cancer Society Institutional Research Grant from the University of Iowa, Holden Comprehensive Cancer Center. The title of this project is Alternative NF-kB and Notch2 Signaling in Splenic Marginal Zone Lymphomagenesis. The award is in the amount of $30,000 and is for the period of December 15, 2015 and should be completed by December 14, 2016.

    Dr. Weizhou Zhang received grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of this project is Obesity, Inflammation and Breast Cancer. This funding total is $1,736,951 and is for the period of December 7, 2015 and should be complete by November 30, 2020.

    Dr. Steven Moore has a new consulting agreement with Flagship Biosciences, Inc. The agreement total is $7,228. This agreement is for the period of October 20, 2015 through October 20, 2018.

    Dr. David Meyerholz has a new research contract negotiated with the Children’s Tumor Foundation for a research project titled The NF1 Porcine Model Collaborative Research Program. The contract total is $931,395. This contract is for the period of October 1, 2015 through October 1, 2018.

    Dr. Vladimir Badovinac received grant funding from the National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS). The title of this project is Impairment and Recovery of CD8 T Cell Responses after Sepsis. This funding total is $1,203,872 and is for the period of September 1, 2015 and should be complete by July 31, 2019.

    Dr. Hasem Habelhah received grant funding from the US Department of Defense/Congressionally Directed Medical Research Program (DOD/CDMRP). The title of this project is Therapeutic Efficacy of Combined TBK1 and AKT Inhibition in Breast Cancer. This funding total is $531,875 and is for the period of September 1, 2015 and should be complete by August 31, 2018.

    Dr. Kevin Legge received Graduate Student Fellowship funding for Zeb Zacharias from the American Association of Immunologists (AAI). The title of this project is Regulation of the CD8 T cell Response to Lethal Influenza A Virus Infections. The award total is $22,920 and is for the period of September 1, 2015 and should be complete by August 31, 2016.

    Dr. Alexander Boyden, a Postdoctoral Fellow in Dr. Nitin Karandikar’s research lab, was awarded a National Multiple Sclerosis Society Postdoctoral Fellowship.  The title of this project is The role of CD8+ regulatory T cells in modulating B cell function during EAE.  The award total is $161,218 and is for the period of July 1, 2015 and should be complete by June 30, 2018.

    Dr. Vladimir Badovinac received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Molecular mechanisms controlling differentiation of memory CD8 T cells. This funding total is $414,335 and is for the period of May 15, 2015 and should be complete by May 31, 2017.

    Dr. Daniel Diekema has a new research contract negotiated with bioMerieux, Inc. for a research project titled VITEK 2 and VITEK 2 Compact GP18 Antimicrobial Susceptibility Tests. The contract total is $64,000. This contract is for the period of May 1, 2015 through May 11, 2018.

    Dr. Ashutosh Mangalam received a notice of grant funding from the National Multiple Sclerosis Society.  The title of this project is Therapeutic potential of combination therapy using Human Gut-derived commensal bacteria and conventional MS drugs.  The amount of this award is $563,264.  The period for this project is April 1, 2015 through March 31, 2018.

    Dr. Aaron Bossler in collaboration with Dr. Guido Tricot (Internal Medicine) received research funding from the Carver College of Medicine, Collaborative Research Grant Program at the University of Iowa. The title of this project is Next-generation sequencing for improved myeloma care in Iowa. The award is in the amount of $50,000 and is for the period of February 1, 2015 and should be complete by March 31, 2017.

    Dr. Weizhou Zhang received a Breast Cancer Research Award from the University of Iowa, Holden Comprehensive Cancer Center. The title of this project is Paracrine non-canonical Wnt signaling in breast cancer. The award is in the amount of $50,000 and is for the period of January 1, 2015 and should be completed by December 31, 2016.

    Dr. Vladimir Badovinac received a Co-PI grant funding with Dr. John Harty from the Department of Microbiology.  The grant was awarded from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID).  The title of this project is Memory CD8 T cell localization and protection from influenza.   This funding total is $1,900,000 and is for the period of November 1, 2014 and should be complete by October 31, 2019.

    Dr. Andrean Simons-Burnett received grant funding from the National Institutes of Health/National Institute of Dental & Craniofacial Research (NIH/NIDCR). The title of this project is Role of inflammation in resistance to EGFR inhibitors in head and neck cancer. This funding total is $1,878,808 and is for the period of July 2, 2014 and should be complete by April 30, 2019.

    Dr. Nitin Karandikar received a notice of grant funding from the National Multiple Sclerosis Society. The title of this project is Role of CNS-Specific Autoreactive CD8+ T Cells in MS. The amount of this award is $712,800. The period for this project is April 1, 2013 through March 31, 2017.

    Dr. Nitin Karandikar received grant funding from the National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is CNS-specific Regulatory CD8+ T cells in autoimmune demyelination. The total direct costs for this award are$1,125,000. The period for this project is May 1, 2011 through April 30, 2017.

    Dr. Vladimir Badovinac received an Oberley Seed Grant from the University of Iowa, Holden Comprehensive Cancer Center. The title of this project is Enhancing anti-tumor CD8 T cell responses for immunotherapy. The award is in the amount of $50,000.

    Dr. Leslie Bruch received a Medical Student Interest Group (MSIG) award from the Intersociety Council for Pathology Information, Inc. (ICPI). This 2015 MSIG award is a useful mechanism to encourage outstanding medical students to consider a career in pathology. The award is in the amount of $750.

    Dr. Kevin Legge and Dr. Thomas Waldschmidt received research funding from Iowa State University for the project with the title of Adaptive immunity and protection generated to nanoparticle-based vaccination against influenza virus. The award is in the amount of $26,415.

    Dr. Steven Moore received funding for a study in collaboration with Sarepta Therapeutics, Inc. The research funding is in the amount of $391,882.

    Dr. Munir Tanas received Sarcoma Pilot Funding from the University of Iowa, Melanoma and Sarcoma Program. The title of this project is Towards the clinical application of WWTR1 and the Hippo pathway in breast cancer:  a translational proposal. The award is in the amount of $30,000.

    Dr. Weizhou Zhang received a V Scholar Grant Award from the V Foundation for Cancer Research. The title of this project is Metformin and Nlrc4-inflammasome in obesity-associated cancer progression. The award is in the amount of $200,000.

    Dr. Weizhou Zhang received an Oberley Seed Grant from the University of Iowa, Holden Comprehensive Cancer Center. The title of this project is TREM-1 facilitates pulmonary metastasis of breast cancer. The award is in the amount of $50,000.